Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2023

Open Access 01-12-2023 | Research

Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies

Authors: Motahareh Hasani, Seyedeh Parisa Alinia, Maryam Khazdouz, Sahar Sobhani, Parham Mardi, Hanieh-Sadat Ejtahed, Mostafa Qorbani

Published in: BMC Cancer | Issue 1/2023

Login to get access

Abstract

Background

The oxidative balance score (OBS) has been utilized to assess the overall pro- and antioxidant exposure status in various chronic diseases. The current meta-analysis was carried out to pool the association between OBS and the risk of cancer.

Methods

We systematically searched the Web of Science, PubMed, Scopus, Embase, and Google Scholar up to August 2023. All observational studies which evaluated the association of OBS with the risk of cancers were included. There was no time of publication or language restrictions. Heterogeneity between studies was assessed using the Chi-square-based Q-test and the I2. A random-effects model meta-analysis was conducted to estimate the pooled effect sizes. Possible sources of heterogeneity were explored by subgroup and meta-regression analysis.

Results

Totally, 15 studies (9 case–control and 6 cohorts) were eligible for meta-analysis. Random effect model meta-analysis of case–control studies showed that higher OBS significantly decreases the odds of cancers (pooled OR: 0.64, 95% CI: 0.54, 0.74). In the cohort studies, the association of OBS with the risk of cancers was not significant (pooled HR: 0.97, 95% CI: 0.80,1.18). The subgroup analysis showed that cancer type and gender were the potential sources of heterogeneity.

Conclusion

Our results show an inverse and significant association between higher OBS and odds of colorectal cancers in case–control and cohort studies. In the case of prostate cancer in cohort studies, our results did not align with the hypothesis. Considering the importance of diet and antioxidant balance in the conditions of malignancy, it is suggested to conduct more comprehensive studies with standard measurement methods to obtain conclusive results.
Literature
1.
McCloy K, et al. Effects of mindfulness-based interventions on fatigue and psychological wellbeing in women with cancer: a systematic review and meta-analysis of randomised control trials. Psychooncology. 2022;31(11):1821–34.PubMedPubMedCentralCrossRef
2.
3.
Jemal A, et al. Global Patterns of Cancer Incidence and Mortality Rates and TrendsGlobal Patterns of Cancer. Cancer Epidemiol Biomarkers Prev. 2010;19(8):1893–907.PubMedCrossRef
4.
5.
Torre LA, et al. Global cancer incidence and mortality rates and trends—an update global cancer rates and trends—an update. Cancer Epidemiol Biomarkers Prev. 2016;25(1):16–27.PubMedCrossRef
6.
Azmanova M, Pitto-Barry A. Oxidative stress in cancer therapy: friend or enemy? ChemBioChem. 2022;23(10): e202100641.PubMedCrossRef
7.
8.
Stanner S, et al. A review of the epidemiological evidence for the ‘antioxidant hypothesis.’ Public Health Nutr. 2004;7(3):407–22.PubMedCrossRef
9.
Arrigoni O, De Tullio MC. Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta. 2002;1569(1–3):1–9.PubMed
10.
Burton GW, Traber MG. Vitamin E: antioxidant activity, biokinetics, and bioavailability. Ann Rev Nutr. 1990;10(1):357–82.CrossRef
11.
Chaudière J, Ferrari-Iliou R. Intracellular antioxidants: from chemical to biochemical mechanisms. Food Chem Toxicol. 1999;37(9–10):949–62.PubMedCrossRef
12.
Mortensen A, Skibsted L, Truscott T. The interaction of dietary carotenoids with radical species. Arch Biochem Biophys. 2001;385(1):13–9.PubMedCrossRef
13.
Barreiro E, et al. Cigarette smoke–induced oxidative stress: a role in chronic obstructive pulmonary disease skeletal muscle dysfunction. Am J Respir Crit Care Med. 2010;182(4):477–88.PubMedCrossRef
14.
15.
Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994;330(15):1029–35.CrossRef
16.
Yun B, et al. Oxidative reactivity across kingdoms in the gut: Host immunity, stressed microbiota and oxidized foods. Free Radic Biol Med. 2022;178:97–110.PubMedCrossRef
17.
Ahmed Q, Rahim S, Hameed A. The effect of hydroxytyrosol (hxt) and local olive oil (loo) on oxidative stress and histopathological changes in the liver resulting from induced hyperlipidaemia in male rats. Int J Med Sci. 2022;5(1):43–54.
18.
Goodman M, et al. A summary measure of pro- and anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas. Cancer Causes Control. 2008;19(10):1051–64.PubMedCrossRef
19.
Park YMM, et al. Dietary inflammatory potential, oxidative balance score, and risk of breast cancer: findings from the Sister Study. Int J Cancer. 2021;149(3):615–26.PubMedPubMedCentralCrossRef
20.
21.
Moher D, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Int Med. 2009;151(4):264–9.PubMedCrossRef
22.
23.
Agalliu I, et al. Oxidative balance score and risk of prostate cancer: results from a case-cohort study. Cancer Epidemiol. 2011;35(4):353–61.PubMedCrossRef
24.
Dash C, et al. Oxidative balance scores and risk of incident colorectal cancer in a US prospective cohort study. Am J Epidemiol. 2015;181(8):584–94.PubMedCrossRef
25.
Sohouli MH, et al. Adherence to oxidative balance scores is associated with a reduced risk of breast cancer; a case-control study. Nutr Cancer. 2022;75(1):164–73.PubMedCrossRef
26.
Dash C, et al. Using pathway-specific comprehensive exposure scores in epidemiology: application to oxidative balance in a pooled case-control study of incident, sporadic colorectal adenomas. Am J Epidemiol. 2013;178(4):610–24.PubMedPubMedCentralCrossRef
27.
Geybels MS, et al. Measures of combined antioxidant and pro-oxidant exposures and risk of overall and advanced stage prostate cancer. Ann Epidemiol. 2012;22(11):814–20.PubMedCrossRef
28.
Kong SYJ, et al. Oxidative balance score, colorectal adenoma, and markers of oxidative stress and inflammationoxidative balance score and markers of oxidative stress. Cancer Epidemiol Biomarkers Prev. 2014;23(3):545–54.PubMedPubMedCentralCrossRef
29.
Mao Z, et al. Dietary and lifestyle oxidative balance scores and incident colorectal cancer risk among older women; the Iowa women’s health study. Nutr Cancer. 2021;73(11–12):2323–35.PubMedCrossRef
30.
31.
Slattery ML, et al. Angiogenesis genes, dietary oxidative balance and breast cancer risk and progression: the breast cancer health disparities study. Int J Cancer. 2014;134(3):629–44.PubMedCrossRef
32.
Bentyaghoob S, et al. Oxidative balance score and dietary phytochemical index can reduce the risk of colorectal cancer in Iranian population. BMC Gastroenterol. 2023;23(1):183.PubMedPubMedCentralCrossRef
33.
Kim J, et al. Gastric cancer risk is reduced by a predominance of antioxidant factors in the oxidative balance: a hospital-based case-control study in Korea. Epidemiol Health. 2022;44: e2022089.PubMedPubMedCentralCrossRef
34.
Goodman M, et al. Combined measure of pro-and anti-oxidant exposures in relation to prostate cancer and colorectal adenoma risk: an update. Ann Epidemiol. 2010;20(12):955–7.PubMedPubMedCentralCrossRef
35.
Ottawa Hospital Research Institute. The Newcastle-Ottawa Scale(NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2014. Accessed 14 Mar 2017.
36.
van Beelen VA, et al. Differential induction of electrophile-responsive element-regulated genes by n− 3 and n− 6 polyunsaturated fatty acids. FEBS Lett. 2006;580(19):4587–90.PubMedCrossRef
37.
Glei M, et al. Iron-overload induces oxidative DNA damage in the human colon carcinoma cell line HT29 clone 19A. Mutat Res. 2002;519(1–2):151–61.PubMedCrossRef
38.
Tappel A. Heme of consumed red meat can act as a catalyst of oxidative damage and could initiate colon, breast and prostate cancers, heart disease and other diseases. Med Hypotheses. 2007;68(3):562–4.PubMedCrossRef
39.
Toborek M, et al. Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells. J Lipid Res. 1996;37(1):123–35.PubMedCrossRef
40.
Ghosh S, et al. Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids. Free Radic Biol Med. 2006;41(9):1413–24.PubMedCrossRef
41.
Rosignoli P, et al. Genotoxic effect of bile acids on human normal and tumour colon cells and protection by dietary antioxidants and butyrate. Eur J Nutr. 2008;47:301–9.PubMedCrossRef
42.
Venturi M, et al. Genotoxic activity in human faecal water and the role of bile acids: a study using the alkaline comet assay. Carcinogenesis. 1997;18(12):2353–9.PubMedCrossRef
43.
Connor WE, et al. Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition. J Clin Investig. 1969;48(8):1363–75.PubMedPubMedCentralCrossRef
44.
45.
Suzuki K, et al. Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study. Cancer Epidemiol Biomarkers Prev. 2004;13(11):1781–7.PubMedCrossRef
46.
Leufkens AM, et al. Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition. Am J Epidemiol. 2012;175(7):653–63.PubMedCrossRef
47.
Wright ME, et al. Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers. Am J Epidemiol. 2004;160(1):68–76.PubMedCrossRef
48.
Van Hoydonck PG, Temme EH, Schouten EG. A dietary oxidative balance score of vitamin C, β-carotene and iron intakes and mortality risk in male smoking Belgians. J Nutr. 2002;132(4):756–61.PubMedCrossRef
49.
Goodman M, et al. Hypothesis: oxidative stress score as a combined measure of pro-oxidant and antioxidant exposures. Ann Epidemiol. 2007;17(5):394–9.PubMedCrossRef
50.
Na HK, Oliynyk S. Effects of physical activity on cancer prevention. Ann New York Acad Sci. 2011;1229(1):176–83.CrossRef
51.
Calder P, Grimble R. Polyunsaturated fatty acids, inflammation and immunity. Eur J Clin Nutr. 2002;56(3):S14–9.PubMedCrossRef
52.
Remigante A, R. Morabito. Cellular and molecular mechanisms in oxidative stress-related diseases. Int J Mol Sci. 2022;23(14):8017.
53.
Sule RO, Condon L, Gomes AV. A common feature of pesticides: oxidative stress—the role of oxidative stress in pesticide-induced toxicity. Oxid Med Cell Longev. 2022;2022:5563759.PubMedPubMedCentralCrossRef
54.
Mourkioti I, et al. Interplay of developmental hippo-notch signaling pathways with the DNA damage response in prostate cancer. Cells. 2022;11(15):2449.PubMedPubMedCentralCrossRef
55.
Orafidiya F, et al. Crosstalk between Long non coding RNAs, microRNAs and DNA damage repair in prostate cancer: new therapeutic opportunities? Cancers. 2022;14(3):755.PubMedPubMedCentralCrossRef
56.
Pathak S, et al. Oxidative stress and cyclooxygenase activity in prostate carcinogenesis: targets for chemopreventive strategies. Eur J Cancer. 2005;41(1):61–70.PubMedCrossRef
57.
Valko M, et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 2006;160(1):1–40.PubMedCrossRef
Metadata
Title
Oxidative balance score and risk of cancer: a systematic review and meta-analysis of observational studies
Authors
Motahareh Hasani
Seyedeh Parisa Alinia
Maryam Khazdouz
Sahar Sobhani
Parham Mardi
Hanieh-Sadat Ejtahed
Mostafa Qorbani
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2023
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-023-11657-w

Other articles of this Issue 1/2023

BMC Cancer 1/2023 Go to the issue

Research

Biochemical and pathophysiological improvements in rats with thioacetamide induced-hepatocellular carcinoma using aspirin plus vitamin C

Research

Clinical benefit of pembrolizumab in treatment of first line non-small cell lung cancer: a systematic review and meta-analysis of clinical characteristics

Research

JMJD6 functions as an oncogene and is associated with poor prognosis in esophageal squamous cell carcinoma

Research

A novel clinically significant prostate cancer prediction system with multiparametric MRI and PSA: P.Z.A. score

Research

Integrated analyzes identify CCT3 as a modulator to shape immunosuppressive tumor microenvironment in lung adenocarcinoma

Research

Analysis of the expression and prognostic significance of DDK complex in Hepatocarcinoma
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits