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Archives of Gynecology and Obstetrics

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01-05-2018 | Gynecologic Oncology

Overexpression of GPNMB predicts an unfavorable outcome of epithelial ovarian cancer

Authors: Rui-qiong Ma, Zhi-jian Tang, Xue Ye, Hong-yan Cheng, Kun-kun Sun, Xiao-hong Chang, Heng Cui

Published in: Archives of Gynecology and Obstetrics | Issue 5/2018

Abstract

Objective

Glycoprotein non-metastatic protein B (GPNMB) is a transmembrane glycoprotein that is expressed at higher levels in several malignant human tissues than those in matched normal tissues. Thus, GPNMB may serve as an attractive therapeutic target of cancer treatment. In this study, the prognostic value of GPNMB expression was examined in tumors derived from a cohort of patients with epithelial ovarian cancer (EOC).

Methods

GPNMB expression in matched formalin-fixed and paraffin-embedded tissue samples was evaluated by immunohistochemistry (IHC), whereas GPNMB mRNA expression in fresh-frozen biopsy tissues was detected using real-time quantitative PCR (qPCR). Meanwhile, the correlations of GPNMB expression with the clinical characteristics of EOC were assessed. Besides, survival data were analysed using Kaplan–Meier and Cox regression analyses, respectively.

Results

GPNMB expression was remarkably upregulated in EOC tissues compared with that in normal ovarian controls at both mRNA and protein levels. In addition, abundant GPNMB expression in EOC was correlated with the International Federation of Gynecology and Obstetrics (FIGO) stage (P < 0.001), residual tumor (P = 0.036), and lymph node metastasis (P = 0.004). Furthermore, results of univariate and multivariate analyses indicated that GPNMB expression level was an independent prognostic factor of the progression-free survival (PFS) and overall survival (OS) (P < 0.001 and P < 0.001, respectively) for EOC patients.

Conclusion

Upregulated GPNMB levels in EOC patients are associated with dismal prognosis. Moreover, findings in the current study indicate that GPNMB is a potentially useful prognostic predictor of the therapeutic approaches for EOC.

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Title: Overexpression of GPNMB predicts an unfavorable outcome of epithelial ovarian cancer
Authors: Rui-qiong Ma
Zhi-jian Tang
Xue Ye
Hong-yan Cheng
Kun-kun Sun
Xiao-hong Chang
Heng Cui
Publication date: 01-05-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 5/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4699-3

At a glance: The STEP trials

Springer Medicine

Overexpression of GPNMB predicts an unfavorable outcome of epithelial ovarian cancer

Abstract

Objective

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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