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World Journal of Urology

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01-06-2021 | Overactive Bladder | Original Article

Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome

Authors: Abubakr H. Mossa, Philippe G. Cammisotto, Samer Shamout, Lysanne Campeau

Published in: World Journal of Urology | Issue 6/2021

Abstract

Purpose

Given the disputable link between nerve growth factor (NGF) and overactive bladder syndrome (OAB) and the lack of studies on its precursor (proNGF) in OAB, the aim of the study was to identify changes in the urinary levels of NGF and its proteolytic enzymes in aging women with OAB.

Methods

We examined the urinary proNGF/NGF ratio and its processing enzymes in aging women (50–80 years), comparing 20 controls and 20 subjects with OAB.

Results

In contrast to previous reports correlating NGF to OAB symptoms, we found that proNGF/NGF ratio in the OAB group was twice as high compared to controls (p = 0.009) with a lower NGF levels in women with OAB without statistical significance [1.36 (Q1, Q3: 0.668, 2.39) vs. 1.7 (Q1, Q3: 1.27, 3.045) pg/mg creatinine in control group, p = 0.05]. Enzymatic activity of MMP-7, the main enzyme for extracellular proNGF maturation, was significantly increased in the OAB group and correlated positively with scores of OAB symptoms questionnaires. However, this was counteracted by several-folds increase in the MMP-9 enzyme responsible for NGF proteolysis. While these findings highlight the importance of changes in the proteolytic enzymes to maintain proNGF/NGF balance in OAB, analysis of covariates showed that these changes were attributed to age, insulin resistance and renal function.

Conclusion

NGF proteolysis imbalance can be clinically meaningful in OAB related to aging, rendering it as a potential therapeutic target. However, other age-related factors such as insulin resistance and renal function may contribute to the relationship between NGF and aging-related OAB phenotype.

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Title: Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome
Authors: Abubakr H. Mossa
Philippe G. Cammisotto
Samer Shamout
Lysanne Campeau
Publication date: 01-06-2021
Publisher: Springer Berlin Heidelberg
Keyword: Overactive Bladder
Published in: World Journal of Urology / Issue 6/2021
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-020-03422-6

2024 ASCO Annual Meeting

Springer Medicine

Imbalance of nerve growth factor metabolism in aging women with overactive bladder syndrome

Abstract

Purpose

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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