Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2014

Open Access 01-12-2014 | Research

Ovarian reserve markers and assisted reproductive technique (ART) outcomes in women with advanced endometriosis

Authors: Safiya A Wahd, Shahla K Alalaf, Talha Al-Shawaf, Namir G Al-Tawil

Published in: Reproductive Biology and Endocrinology | Issue 1/2014

Login to get access

Abstract

Background

The role of ovarian reserve markers as predictors of the controlled ovarian stimulation (COS) response in intracytoplasmic sperm injection (ICSI) cycles in women with endometriosis has been much debated. The aim of the present study is to assess the predictability of ovarian reserve markers for the number of mature oocytes (MII) retrieved and to assess the pregnancy rate and live birth rate in women with advanced endometriosis.

Methods

Two hundred eighty-five infertile women who had laparoscopy followed by a first ICSI cycle were recruited in this prospective study. One hundred ten patients were diagnosed with endometriosis stage III-IV (group 1), and 175 patients had no endometriosis (group II). Sixty-three patients in group 1 had no history of previous endometrioma surgery (group Ia), and 47 patients had a history of previous endometrioma surgery (group Ib).

Results

The number of mature oocytes retrieved was significantly lower in women with advanced endometriosis than in women with no endometriosis. The number of mature oocytes retrieved in women with and without endometriosis was best predicted by antral follicle count (AFC) and age, whereas only AFC was a predictor in women with previous endometrioma surgery (odds ratio: 0.49; 95% confidence interval: 0.13-0.60). Women with endometriosis had a lower rate of live births than the control group, but this difference was not statistically significant; the number of live births was significantly lower in those with previous endometrioma surgery.

Conclusions

The best predictor of the COS response in ICSI was AFC, followed by age. Women receiving ICSI following surgery for ovarian endometrioma had a poorer clinical outcome and lower rate of live births compared with those with endometriosis but no previous surgery and the control group.
Appendix
Available only for authorised users
Literature
1.
2.
3.
Ozkan S, Murk W, Arici A: Endometriosis and infertility: epidemiology and evidence-based treatments. Ann N Y Acad Sci. 2008, 1127: 92-100. 10.1196/annals.1434.007.CrossRefPubMed
4.
Bulletti C, Coccia ME, Battistoni S, Borini A: Endometriosis and infertility. Assist Reprod Genet. 2010, 27: 441-447. 10.1007/s10815-010-9436-1.CrossRef
5.
Yoo JH, Cha SH, Park CW, Kim JY, Yang KM, Song IO, Koong MK, Kang IS, Kim HO, Kim HO: Serum anti-Müllerian hormone is a better predictor of ovarian response than FSH and age in IVF patients with endometriosis. Clin Exp Reprod Med. 2011, 38 (4): 222-227. 10.5653/cerm.2011.38.4.222. doi:10.5653/cerm.2011.38.4.222. Epub 2011 Dec 31PubMedCentralCrossRefPubMed
6.
Park CW, Song IO, Koong MK: IVF/ICSI outcomes of women with minimal to mild endometriosis associated infertility and unexplained infertility. Korean J Obstet Gynecol. 2007, 50: 322-328.
7.
Hock DL, Sharafi K, Dagostino L, Kemmann E, Seifer DB: Contribution of diminished ovarian reserve to hypofertility associated with endometriosis. J Reprod Med. 2001, 46: 7-10.PubMed
8.
Barnhart K, Dunsmoor-Su R, Coutifaris C: Effect of endometriosis on in vitro fertilization. Fertil Steril. 2002, 77: 1148-1155. 10.1016/S0015-0282(02)03112-6.CrossRefPubMed
9.
Iwase A, Hirokawa W, Goto M, Takikawa S, Nagatomo Y, Nakahara T, Manabe S, Kikkawa F: Serum anti-Mullerian hormone level is a useful marker for evaluating the impact of laparoscopic cystectomy on ovarian reserve. Fertil Steril. 2010, 94: 2846-2849. 10.1016/j.fertnstert.2010.06.010.CrossRefPubMed
10.
Hirokawa W, Iwase A, Goto M, Takikawa S, Nagatomo Y, Nakahara T, Bayasula B, Nakamura T, Manabe S, Kikkawa F: The post-operative decline in serum anti-Mullerian hormone correlates with the bilaterality and severity of endometriosis. Hum Reprod. 2011, 26: 904-910. 10.1093/humrep/der006.CrossRefPubMed
11.
Shebl O, Ebner T, Sommergruber M, Sir A, Tews G: Anti Muellerian hormone serum levels in women with endometriosis: a case–control study. Gynecol Endocrinol. 2009, 25: 713-716. 10.3109/09513590903159615.CrossRefPubMed
12.
Esinler I, Bozdag G, Aybar F, Bayar U, Yarali H: Outcome of in vitro fertilization/intracytoplasmic sperm injection after laparoscopic cystectomy for endometriomas. Fertil Steril. 2006, 85: 1730-1735. 10.1016/j.fertnstert.2005.10.076.CrossRefPubMed
13.
Matalliotakis IM, Cakmak H, Mahutte N, Fragouli Y, Arici A, Sakkas D: Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007, 88: 1568-1572. 10.1016/j.fertnstert.2007.01.037.CrossRefPubMed
14.
Al-Azemi M, Bernal AL, Steele J, Gramsbergen I, Barlow D, Kennedy S: Ovarian response to repeated controlled stimulation in in-vitro fertilization cycles in patients with ovarian endometriosis. Hum Reprod. 2000, 15: 72-75. 10.1093/humrep/15.1.72.CrossRefPubMed
15.
Almog B, Shehata F, Sheizaf B, Tan SL, Tulandi T: Effects of ovarian endometrioma on the number of oocytes retrieved for in vitro fertilization. Fertil Steril. 2011, 95: 525-527. 10.1016/j.fertnstert.2010.03.011.CrossRefPubMed
16.
Benaglia L, Pasin R, Somigliana E, Vercellini P, Ragni G, Fedele L: Unoperated ovarian endometriomas and responsiveness to hyperstimulation. Hum Reprod. 2011, 26: 1356-1361. 10.1093/humrep/der097.CrossRefPubMed
17.
18.
American Society for Reproductive Medicine: Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997, 67: 817-821. 10.1016/S0015-0282(97)81391-X.CrossRef
19.
Practice Committee of the American Society for Reproductive Medicine: Testing and interpreting measures of ovarian reserve: a committee opinion. Fertil Steril. 2012, 98: 1407-1415.CrossRef
20.
Nelson SM: Biomarkers of ovarian response: current and future applications. Fertil Steril. 2013, 99: 963-969. 10.1016/j.fertnstert.2012.11.051.CrossRefPubMed
21.
Shah DK, Mejia RB, Lebovic D: Effect of surgery for endometrioma on ovarian function. J Minim Invasive Gynecol. 2014, 21: 203-209. 10.1016/j.jmig.2013.09.012.CrossRefPubMed
22.
Geber S, Ferreira DP, Spyer Prates LF, Sales L, Sampaio M: Effects of previous ovarian surgery for endometriosis on the outcome of assisted reproduction treatment. Reprod Biomed Online. 2002, 5: 162-166. 10.1016/S1472-6483(10)61619-7.CrossRefPubMed
23.
Ho HY, Lee RK, Hwu YM, Lin MH, Su JT, Tsai YC: Poor response of ovaries with endometrioma previously treated with cystectomy to controlled ovarian hyperstimulation. J Assist Reprod Genet. 2002, 19: 507-511. 10.1023/A:1020970417778.PubMedCentralCrossRefPubMed
24.
Raffi F, Metwally M, Amer S: The impact of excision of ovarian endometrioma on ovarian reserve: a systematic review and meta-analysis. J Clin Endocrinol Metab. 2012, 97: 3146-3154. 10.1210/jc.2012-1558.CrossRefPubMed
25.
Somigliana E, Berlanda N, Benaglia L, Vigano’ P, Vercellini P, Fedele L: Surgical excision of endometriomas and ovarian reserve: a systematic review on serum antiMu¨llerian hormone level modifications. Fertil Steril. 2012, 98: 1531-1538. 10.1016/j.fertnstert.2012.08.009.CrossRefPubMed
26.
Bongioanni F, Revelli A, Gennarelli G, Guidetti D, Delle Piane LD, Holte J: Ovarian endometriomas and IVF: a retrospective case–control study. Reprod Biol Endocrinol. 2011, 17: 9-81.
27.
Hachisuga T, Kawarabayashi T: Histopathological analysis of laparoscopically treated ovarian endometriotic cysts with special reference to loss of follicles. Hum Reprod. 2002, 17: 432-435. 10.1093/humrep/17.2.432.CrossRefPubMed
28.
Muzii L, Bianchi A, Bellati F, Cristi E, Pernice M, Zullo MA, Angioli R, Panici PB: Histologic analysis of endometriomas: what the surgeon needs to know. Fertil Steril. 2007, 87: 362-366. 10.1016/j.fertnstert.2006.06.055.CrossRefPubMed
29.
Kumbak B, Kahraman S, Karlikaya G, Lacin S, Guney A: In vitro fertilization in normoresponder patients with endometriomas comparison with basal simple ovarian cysts. Gynecol Obstet Invest. 2008, 65: 212-216. 10.1159/000112310.CrossRefPubMed
30.
Canis M, Pouly JL, Tamburro S, Mage G, Wattiez A, Bruhat MA: Ovarian response during IVF-embryo transfer cycles after laparoscopic cysts of >3 cm in diameter. Hum Reprod. 2001, 16: 2583-2586. 10.1093/humrep/16.12.2583.CrossRefPubMed
31.
Donnez J, Wyns C, Nisolle M: Does ovarian surgery for endometriomas impair the ovarian response to gonadotropin?. Fertil Steril. 2001, 76: 662-665. 10.1016/S0015-0282(01)02011-8.CrossRefPubMed
32.
Lemos NA, Arbo E, Scalco R, Weiler E, Rosa V, Cunha-Filho JS: Decreased anti-Mullerian hormone and altered ovarian follicular cohort in infertile patients with mild/minimal endometriosis. Fertil Steril. 2008, 89: 1064-1068. 10.1016/j.fertnstert.2007.04.048.CrossRefPubMed
33.
Barri PN, Coroleu B, Tur R, Barri-Soldevila PN, Rodríguez I: Endometriosis-associated infertility surgery and IVF a comprehensive therapeutic approach. Reprod Biomed Online. 2010, 21: 179-185. 10.1016/j.rbmo.2010.04.026.CrossRefPubMed
34.
Muzii L, Di Tucci C, Di Feliciantonio M, Marchetti C, Perniola G, Panici PB: The effect of surgery for endometrioma on ovarian reserve evaluated by antral follicle count: a systematic review and meta-analysis. Hum Reprod. 2014, 29: 2190-2198. 10.1093/humrep/deu199.CrossRefPubMed
35.
Muzii L, Miller CE: The singer, not the song. J Minim Invasive Gynecol. 2011, 18: 666-667. 10.1016/j.jmig.2011.06.016.CrossRefPubMed
36.
Kuivasaari P, Hippelainen M, Anttila M, Heinonen S: Effect of endometriosis on IVF/ICSI outcome: stage III/IV endometriosis worsens cumulative pregnancy and live-born rates. Hum Reprod. 2005, 20: 3130-3135. 10.1093/humrep/dei176.CrossRefPubMed
37.
Al-Fadhli R, Kelly SM, Tulandi T, Tanr SL: Effects of different stages of endometriosis on the outcome of in vitro fertilization. J Obstet Gynaecol Can. 2006, 28: 888-891.PubMed
38.
Oehninger S, Acosta AA, Kreiner D, Muasher SJ, Jones HW, Rosenwaks Z: In vitro fertilization and embryo transfer (IVF/ET): an established and successful therapy for endometriosis. J In Vitro Fert Embryo Transf. 1988, 5: 249-256. 10.1007/BF01132172.CrossRefPubMed
39.
Coccia ME, Rizzello F, Mariani G, Bulletti C, Palagiano A, Scarselli G: Impact of endometriosis on in vitro fertilization and embryo transfer cycles in young women: a stage-dependent interference. Acta Obstet Gynecol Scand. 2011, 90: 1232-1238. 10.1111/j.1600-0412.2011.01247.x.CrossRefPubMed
40.
Dmowski WP, Rana N, Michalowska J, Friberg J, Papierniak C, el-Roeiy A: The effect of endometriosis, its stage and activity, and of autoantibodies on in vitro fertilization and embryo transfer success rates. Fertil Steril. 1995, 63: 555-562.PubMed
41.
Opoien HK, Fedorcsak P, Omland AK, Abyholm T, Bjercke S, Ertzeid G, Oldereid N, Mellembakken JR, Tanbo T: In vitro fertilization is a successful treatment in endometriosis-associated infertility. Fertil Steril. 2012, 97: 912-918. 10.1016/j.fertnstert.2012.01.112.CrossRefPubMed
42.
Tsoumpou I, Kyrgiou M, Gelbaya TA, Nardo LG: The effect of surgical treatment for endometrioma on in vitro fertilization outcomes: a systematic review and meta-analysis. Fertil Steril. 2009, 92: 75-87. 10.1016/j.fertnstert.2008.05.049.CrossRefPubMed
43.
Gupta S, Agarwal A, Agarwal R, Loret de Mola JR: Impact of ovarian endometrioma on assisted reproduction outcomes. Reprod Biomed Online. 2006, 13: 349-360. 10.1016/S1472-6483(10)61439-3.CrossRefPubMed
44.
Surrey ES, Silverberg KM, Surrey MW, Schoolcraft WB: Effect of prolonged gonadotropin-releasing hormone agonist therapy on the outcome of in vitro fertilization-embryo transfer in patients with endometriosis. Fertil Steril. 2002, 78: 699-704. 10.1016/S0015-0282(02)03373-3.CrossRefPubMed
45.
de Ziegler D, Gayet V, Aubriot FX, Fauque P, Streuli I, Wolf JP, de Mouzon J, Chapron C: Use of oral contraceptives in women with endometriosis before assisted reproduction treatment improves outcomes. Fertil Steril. 2010, 94: 2796-2979. 10.1016/j.fertnstert.2010.05.056.CrossRefPubMed
46.
Saito H, Seino T, Kaneko T, Nakahara K, Toya M, Kurachi H: Endometriosis and oocyte quality. Gynecol Obstet Invest. 2002, 53 (Suppl 1): 46-51.CrossRefPubMed
Metadata
Title
Ovarian reserve markers and assisted reproductive technique (ART) outcomes in women with advanced endometriosis
Authors
Safiya A Wahd
Shahla K Alalaf
Talha Al-Shawaf
Namir G Al-Tawil
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2014
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-12-120

Other articles of this Issue 1/2014

Reproductive Biology and Endocrinology 1/2014 Go to the issue

Research

Afamin serum concentrations are associated with insulin resistance and metabolic syndrome in polycystic ovary syndrome

Research

A large, multicentre, observational, post-marketing surveillance study of the 2:1 formulation of follitropin alfa and lutropin alfa in routine clinical practice for assisted reproductive technology

Research

Recombinant human follicle-stimulating hormone (r-hFSH) plus recombinant luteinizing hormone versus r-hFSH alone for ovarian stimulation during assisted reproductive technology: systematic review and meta-analysis

Research

Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects

Research

Fertility awareness among medical and non-medical students: a case-control study

Research

Leucine-rich diet supplementation modulates foetal muscle protein metabolism impaired by Walker-256 tumour