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Journal of Medical Case Reports

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Open Access 01-12-2012 | Case report

Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report

Authors: Usama Al-Jumaily, Maysa Al-Hussaini, Fatenah Ajlouni, Abdulrahman Abulruz, Iyad Sultan

Published in: Journal of Medical Case Reports | Issue 1/2012

Abstract

Introduction

Development of a sarcomatous component in a germ cell tumor is an uncommon phenomenon. Most cases reported have a grim prognosis. Growing teratoma syndrome is also an uncommon phenomenon and occurs in approximately 2% to 7% of non seminomatous germ cell tumors and should be treated surgically.

Case presentation

We report the case of a 12-year-old Asian girl with an ovarian mixed germ cell tumor containing a rhabdomyosarcomatous component. She was treated with a germ cell tumor chemotherapy regimen and rhabdomyosarcoma-specific chemotherapy. Towards the end of her treatment, she developed a retroperitoneal mass that was increasing in size. It was completely resected, revealing a mature teratoma, consistent with growing teratoma syndrome. She is still in complete remission approximately three years after presentation.

Conclusion

The presence of rhabdomyosarcoma in a germ cell tumor should be treated by a combined chemotherapy regimen (for germ cell tumor and rhabdomyosarcoma). In addition, development of a mass during or after therapy with normal serum markers should raise the possibility of growing teratoma syndrome that should be treated surgically.

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Title: Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report
Authors: Usama Al-Jumaily
Maysa Al-Hussaini
Fatenah Ajlouni
Abdulrahman Abulruz
Iyad Sultan
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2012
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/1752-1947-6-13

At a glance: The STEP trials

Springer Medicine

Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report

Abstract

Introduction

Case presentation

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Case presentation

Conclusion

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