Top

Published in:

01-05-2008 | Original Article

Outcome of lupus nephritis in Iranian children: prognostic significance of certain features

Authors: Neamatollah Ataei, Manijeh Haydarpour, Abbas Madani, Seyed Taher Esfahani, Niloufar Hajizadeh, Mohammad Hasan Moradinejad, Taghi Gholmohammadi, Shahriar Arbabi, Marzieh Haddadi

Published in: Pediatric Nephrology | Issue 5/2008

Abstract

The objective of this study was to determine the clinical and histopathological features and outcome of children with lupus nephritis (LN). Of 84 children with systemic lupus erythematosus (SLE), we retrospectively studied 58 children (69%) under 15 years of age with biopsy-proven LN who had been followed between October 1989 and January 2005. The mean age at diagnosis or initial referral was 10.6 ± 2.25 years, and the mean follow-up was 5.3 ± 4.1 years. Class IV LN was observed in 34 (58.6%) patients. The 5-year patient and renal survival rates were 82.5 and 78.5%, respectively, in the total group, and 75 and 85.8%, respectively, in patients with Class IV LN. No independent predictor of unfavorable outcome, including renal histology, was detected by multivariate analysis. The mid-term patient and the renal survival rates of Iranian children with biopsy-proven LN are high. Within 5 years of follow-up, renal histology was not a predictor for survival.

Lehman TJ (1991) Long-term outcome of systemic lupus erythematosus in childhood. Rheum Dis Clin North Am 17:921–930PubMed

Austin HA, Balow JE (1999) Natural history and treatment of lupus nephritis. Semin Nephrol 19:2–11PubMed

Cameron JS (1994) Lupus nephritis in childhood and adolescence. Pediatr Nephrol 8:230–249CrossRefPubMed

Stichweh D, Arce E, Pascual V (2004) Update on pediateric systemic lupus erythmatosus. Curr Opin Rheumatol 16:577–587CrossRefPubMed

McCurdy DK, Lehman TJ, Bernstein B, Hanson V, King KK, Nadorra R, Landing BH (1992) Lupus nephritis: prognostic factors in children. Pediatrics 89:240–246PubMed

Tejani A, Nicastri AD, Chen CK, Fikrig S, Gurumurthy K (1983) Lupus nephritis in black and Hispanic children. Am J Dis Child 137:481–483PubMed

Appel GB, Cohen DJ, Pirani CL, Meltzer JI, Estes D (1987) Long-term follow-up of patients with lupus nephritis. A study based on the classification of the World Health Organization. Am J Med 83:877–885CrossRefPubMed

Studenski S, Allen NB, Caldwell DS, Rice JR, Polisson RP (1987) Survival in systemic lupus erythematosus. A multivariate analysis of demographic factors. Arthritis Rheum 30:1326–1332CrossRefPubMed

Seleznick MJ, Fries JF (1991) Variables associated with decreased survival in systemic lupus erythematosus. Semin Arthritis Rheum 21:73–80CrossRefPubMed

10.

Epstein WV, Grausz H (1974) Favorable outcome in diffuse proliferative glomerulonephritis of systemic lupus erythematosus. Arthritis Rheum 17:129–142CrossRefPubMed

11.

Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ (1982) The revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277CrossRefPubMed

12.

Churg J, Sobin LH (1982) WHO monograph: renal disease. Classification and atlas of glomerular disease. Igaku-Soin, New York

13.

Churg J, Bernstein J, Glassock RJ (1995) WHO monograph: renal disease. Classification and atlas of glomerular diseases. Igaky-Shoin, New York

14.

Schwartz GJ, Brion LP, Spitzer A (1987) The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children and adolescents. Pediatr Clin North Am 34:571–590CrossRefPubMed

15.

National High Blood Pressure Education Program (1996) Update on the 1987 Task Force report on high blood pressure in children and adolescents: a working group report from the National High Blood Pressure Education Program. Pediatrics 98:649–658

16.

Austin HA, Muenz LR, Joyce KM, Antonovych TA, Kullick ME, Klippel JH, Decker JL, Balow JE (1983) Prognostic factors in lupus nephritis. Am J Med 75:382–391CrossRefPubMed

17.

Austin HA, Muenz LR, Joyce KM, Antonovych TA, Balow JE (1984) Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome. Kidney Int 25:689–695CrossRefPubMed

18.

Nossent HC, Henzen-Logmans SC, Vroom TM, Berden JH, Swaak TJ (1990) Contribution of renal biopsy data in predicting outcome in lupus nephritis. Arthritis Rheum 33:970–976CrossRefPubMed

19.

Bahabri S, Al Sabban E, Al Rashed A, Al-Moyouf S, Al Mazyed A, Abdulrazik A, Al-Dalaan A (1997) Juvenile systemic lupus erythematosus in 60 Saudi children. Ann Saudi Med 17:612–615CrossRefPubMed

20.

Huang JL, Lin CJ, Hung IJ, Luo SF (1994) The morbidity and mortality associated with childhood onset systemic lupus erythematosus. Changgeng Yi Xue Za Zhi 17:113–120PubMed

21.

Singh S, Devidayal, Kumar L, Joshi K (2002) Mortality patterns in childhood lupus: 10 years’ experience in a developing country. Clin Rheumatol 21:462–465CrossRefPubMed

22.

Barbano GC, Gusmano R, Damasio B, Alpigiani MG, Buoncompagni A, Gattorno M, Perfumo F (2002) Childhood-onset lupus nephritis: a single-center experience of pulse intravenous cyclophosphamide therapy. J Nephrol 15:123–129PubMed

23.

Wang LC, Yang YH, Lu MY Chiang BL (2004) Retrospective analysis of the renal outcome of pediatric lupus nephritis. Clin Rheumatol 23:318–323CrossRefPubMed

24.

Hagelberg S, Lee Y, Bargman J, Mah G, Schneider R, Laskin C, Eddy A, Gladman D, Urowitz M, Hebert D, Silverman E (2002) Long-term follow-up of childhood lupus nephritis. J Rheumatol 29:2635–2642PubMed

25.

Khoo JJ, Pee S, Thevarajah B, Yap YC, Chin CK (2005) Lupus nephritis in children in Malaysia. J Paediatr Child Health 41:31–35CrossRefPubMed

26.

Font J, Cervera R, Espinosa G, Pallares L, Ramos-Casals M, Jimenez S, Garcia-Carrasco M, Seisdedos L, Ingelmo M (1998) Systemic lupus erythematosus (SLE) in childhood: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults. Ann Rheum Dis 57:456–459CrossRefPubMedPubMedCentral

27.

Emre S, Bilage I, Sirin A, Kilicaslan I, Nayir A, Okteon F, Uysal V (2001) Lupus nephritis in children: prognostic significance of clinicopathological findings. Nephron 87:118–126CrossRefPubMed

28.

Bogdanovic R, Nikolic V, Pasic S, Dimitrijevic J, Lipkovska-Markovic J, Eric-Marinkovic J, Ognjanovic M, Minic A, Stajic N (2004) Lupus nephritis in childhood: a review of 53 patients followed at a single center. Pediatr Nephrol 19:36–44CrossRefPubMed

29.

Baqi N, Moazami S, Singh A, Ahmad H, Balachandra S, Tejani A (1996) Lupus nephritis in children: a longitudinal study of prognostic factors and therapy. J Am Soc Nephrol 7:924–929PubMed

30.

Huong DL, Papo T, Beaufils H, Wechsler B, Bletry O, Baumelou A, Godeau P, Piette JC (1999) Renal involvement in systemic lupus erythematosus. A study of 180 patients from a single center. Medicine 78:148–166CrossRefPubMed

31.

Lehman TJ, Mc Curdy DK, Bernstein BH, King KK (1989) Systemic lupus erythematosus in the first decade of life. Pediatrics 83:235–239PubMed

32.

Mosca M, Pasquariello A, Tavoni A, Moriconi L, Moneta I, Innocenti M, Bencivelli W, Bombardieri S (1997) Predictors of renal outcome in diffuse proliferative glomerulonephritis in systemic lupus erythematosus. Lupus 6:371–378CrossRefPubMed

33.

Yang LY, Chen WP, Lin CY (1994) Lupus nephritis in children – a review of 167 patients. Pediatrics 94:355–360

34.

Mok CC, Wong RW, Lau CS (1999) Lupus nephritis in Southern Chinese patients: clinicopathologic findings and long-term outcome. Am J Kidney Dis 34:315–323CrossRefPubMed

35.

Silverman E (1996) What’s new in the treatment of pediatric SLE. J Rheumatol 23:1657–1660PubMed

36.

Niaudet P (2000) Treatment of lupus nephritis in children. Pediatr Nephrol 14:158–166CrossRefPubMed

37.

Contreras G, Pardo V, Leclercq B, Lenz O, Tozman E, O’Nan P, Roth D (2004) Sequential therapies for proliferative lupus nephritis. N Engl J Med 4:971–980CrossRef

Title: Outcome of lupus nephritis in Iranian children: prognostic significance of certain features
Authors: Neamatollah Ataei
Manijeh Haydarpour
Abbas Madani
Seyed Taher Esfahani
Niloufar Hajizadeh
Mohammad Hasan Moradinejad
Taghi Gholmohammadi
Shahriar Arbabi
Marzieh Haddadi
Publication date: 01-05-2008
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 5/2008
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0713-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Outcome of lupus nephritis in Iranian children: prognostic significance of certain features

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 5/2008

Masked severe stenosing ureteritis: a rare complication of Henoch-Schönlein purpura

Therapeutic strategies to slow chronic kidney disease progression

Blood-volume monitoring in paediatric haemodialysis

Global left-ventricular function by tissue Doppler imaging in pediatric dialysis patients

Hypertension and segmental renal infarction in children: apropos of two cases

Clinical features of community-acquired Pseudomonas aeruginosa urinary tract infections in children