Top

European Spine Journal

Published in:

03-11-2023 | Osteoporosis | Original Article

Prognostic nutritional index and modified frailty index, independent risk factors for recompression in elderly patients with osteoporotic vertebral compression fractures

Authors: Gang Ju, Xiaoqing Liu

Published in: European Spine Journal | Issue 4/2024

Abstract

Background

To identify some clinical and laboratory independent risk factors for postoperative recompression among elderly osteoporotic vertebral compression fractures (OVCF) patients.

Methods

A retrospective analysis was conducted on 287 elderly OVCF patients after percutaneous vertebroplasty (PVP). Relevant risk factors for recompression were screened and further analyzed through multivariate logistic regression.

Results

Within postoperative 1 year, recompression had occurred in 72 patients, with an incidence of 25.1% (72/287). Multivariate logistic analysis indicated that mean spinal BMD < − 2.85 (OR: 4.55, 95%CI 2.22–9.31, P < 0.001), ODI ≥ 68.05% (OR: 6.78, 95%CI 3.16–14.55, P < 0.001), PNI score < 43.1 (OR: 2.81, 95%CI 1.34–5.82, P = 0.005), and mFI score ≥ 0.225 (OR: 8.30, 95%CI 3.14–21.95, P < 0.001) were four distinct risk factors that independently contributed to postoperative recompression.

Conclusions

Spinal BMD, ODI, PNI and mFI independently predict recompression in OVCF patients after PVP treatment.

Buchbinder R, Johnston RV, Rischin KJ et al (2018) Percutaneous vertebroplasty for osteoporotic vertebral compression fracture. Cochrane Database Syst Rev 4(4): CD006349.

Dai C, Liang G, Zhang Y, Dong Y, Zhou X (2022) Risk factors of vertebral re-fracture after PVP or PKP for osteoporotic vertebral compression fractures, especially in Eastern Asia: a systematic review and meta-analysis. J Orthop Surg Res 17(1):161CrossRefPubMedPubMedCentral

Firanescu CE, de Vries J, Lodder P et al (2018) Vertebroplasty versus sham procedure for painful acute osteoporotic vertebral compression fractures (VERTOS IV): randomised sham controlled clinical trial. BMJ 361:k1551CrossRefPubMedPubMedCentral

Luthman S, Widén J, Borgström F (2018) Appropriateness criteria for treatment of osteoporotic vertebral compression fractures. Osteoporos Int 29(4):793–804CrossRefPubMed

Patel D, Liu J, Ebraheim NA (2022) Managements of osteoporotic vertebral compression fractures: a narrative review. World J Orthop 13(6):564–573CrossRefPubMedPubMedCentral

Zhu RS, Kan SL, Ning GZ et al (2019) Which is the best treatment of osteoporotic vertebral compression fractures: balloon kyphoplasty, percutaneous vertebroplasty, or non-surgical treatment? A Bayesian network meta-analysis Osteoporos Int 30(2):287–298PubMed

Zhang Z, Jiao F, Huang H et al (2019) A second puncture and injection technique for treating osteoporotic vertebral compression fractures. J Orthop Surg Res 14(1):413CrossRefPubMedPubMedCentral

Hulme PA, Krebs J, Ferguson SJ, Berlemann U (2006) Vertebroplasty and kyphoplasty: a systematic review of 69 clinical studies. Spine (Phila Pa 1976) 31(17): 1983–2001.

Camacho PM, Petak SM, Binkley N et al (2020) American association of clinical endocrinologists/american college of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis—2020 update executive summary. Endocr Pract 26(5):564–570CrossRefPubMed

10.

Yu W, Liang D, Yao Z et al (2017) Risk factors for recollapse of the augmented vertebrae after percutaneous vertebroplasty for osteoporotic vertebral fractures with intravertebral vacuum cleft. Medicine (Baltimore) 96(2):e5675CrossRefPubMed

11.

An Z, Chen C, Wang J et al (2021) Logistic regression analysis on risk factors of augmented vertebra recompression after percutaneous vertebral augmentation. J Orthop Surg Res 16(1):374CrossRefPubMedPubMedCentral

12.

Farhat JS, Velanovich V, Falvo AJ et al (2012) Are the frail destined to fail? Frailty index as predictor of surgical morbidity and mortality in the elderly. J Trauma Acute Care Surg 72(6):1526–1530; discussion 1530–1531.

13.

Meng Y, Zhao P, Yong R (2021) Modified frailty index independently predicts postoperative pulmonary infection in elderly patients undergoing radical gastrectomy for gastric cancer. Cancer Manag Res 13:9117–9126CrossRefPubMedPubMedCentral

14.

Zhu S, Cheng Z, Hu Y et al (2021) Prognostic value of the systemic immune-inflammation index and prognostic nutritional index in patients with medulloblastoma undergoing surgical resection. Front Nutr 8:754958CrossRefPubMedPubMedCentral

15.

Fairbank JC, Pynsent PB (2000) The oswestry disability index. Spine (Phila Pa 1976) 25(22):2940–2952; discussion 2952.

16.

Voormolen MH, Mali WP, Lohle PN et al (2007) Percutaneous vertebroplasty compared with optimal pain medication treatment: short-term clinical outcome of patients with subacute or chronic painful osteoporotic vertebral compression fractures. The VERTOS study. AJNR Am J Neuroradiol 28(3):555–560.

17.

Zhang L, Wang Q, Wang L, Shen J, Zhang Q, Sun C (2017) Bone cement distribution in the vertebral body affects chances of recompression after percutaneous vertebroplasty treatment in elderly patients with osteoporotic vertebral compression fractures. Clin Interv Aging 12:431–436CrossRefPubMedPubMedCentral

18.

Gaughen JR Jr, Jensen ME, Schweickert PA, Marx WF, Kallmes DF (2002) The therapeutic benefit of repeat percutaneous vertebroplasty at previously treated vertebral levels. AJNR Am J Neuroradiol 23(10):1657–1661PubMedPubMedCentral

19.

Zhang Z, Fan J, Ding Q, Wu M, Yin G (2013) Risk factors for new osteoporotic vertebral compression fractures after vertebroplasty: a systematic review and meta-analysis. J Spinal Disord Tech 26(4):E150–E157CrossRefPubMed

20.

Li YX, Guo DQ, Zhang SC et al (2018) Risk factor analysis for re-collapse of cemented vertebrae after percutaneous vertebroplasty (PVP) or percutaneous kyphoplasty (PKP). Int Orthop 42(9):2131–2139CrossRefPubMed

21.

Onodera T, Goseki N, Kosaki G (1984) Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients. Nihon Geka Gakkai Zasshi 85(9):1001–1005PubMed

22.

Meyer M, Leiss F, Greimel F et al (2021) Impact of malnutrition and vitamin deficiency in geriatric patients undergoing orthopedic surgery. Acta Orthop 92(3):358–363CrossRefPubMedPubMedCentral

23.

Fang XY, Xu HW, Chen H et al (2022) Association between poor nutritional status and increased risk for subsequent vertebral fracture in elderly people with percutaneous vertebroplasty. Clin Interv Aging 17:1503–1512CrossRefPubMedPubMedCentral

24.

Nagai T, Uei H, Nakanishi K (2022) Association among geriatric nutritional risk index and functional prognosis in elderly patients with osteoporotic vertebral compression fractures. Indian J Orthop 56(2):338–344CrossRefPubMed

25.

Gupta A, Upadhyaya S, Cha T, Schwab J, Bono C, Hershman S (2019) Serum albumin levels predict which patients are at increased risk for complications following surgical management of acute osteoporotic vertebral compression fractures. Spine J 19(11):1796–1802CrossRefPubMed

26.

Araújo-Andrade L, Rocha-Neves JP, Duarte-Gamas L et al (2020) Prognostic effect of the new 5-factor modified frailty index in patients undergoing carotid endarterectomy with regional anesthesia—a prospective cohort study. Int J Surg 80:27–34CrossRefPubMed

27.

Lambrechts MJ, Tran K, Conaway W et al (2023) Modified frailty index as a predictor of postoperative complications and patient-reported outcomes after posterior cervical decompression and fusion. Asian Spine J 17(2):313–321

28.

Kim HJ, Park S, Park SH et al (2018) Prevalence of frailty in patients with osteoporotic vertebral compression fracture and its association with numbers of fractures. Yonsei Med J 59(2):317–324CrossRefPubMed

29.

Jung JM, Chung CK, Kim CH, Yang SH, Ko YS (2022) The modified 11-item frailty index and postoperative outcomes in patients undergoing lateral lumbar interbody fusion. Spine (Phila Pa 1976) 47(5):396–404.

30.

Zhang J, He X, Fan Y, Du J, Hao D (2019) Risk factors for conservative treatment failure in acute osteoporotic vertebral compression fractures (OVCFs). Arch Osteoporos 14(1):24CrossRefPubMed

31.

Tom SE, Adachi JD, Anderson FA Jr et al (2013) Frailty and fracture, disability, and falls: a multiple country study from the global longitudinal study of osteoporosis in women. J Am Geriatr Soc 61(3):327–334CrossRefPubMedPubMedCentral

32.

Kojima G (2016) Frailty as a predictor of fractures among community-dwelling older people: a systematic review and meta-analysis. Bone 90:116–122CrossRefPubMed

33.

Park JS, Park YS (2021) Survival analysis and risk factors of new vertebral fracture after vertebroplasty for osteoporotic vertebral compression fracture. Spine J 21(8):1355–1361CrossRefPubMed

Title: Prognostic nutritional index and modified frailty index, independent risk factors for recompression in elderly patients with osteoporotic vertebral compression fractures
Authors: Gang Ju
Xiaoqing Liu
Publication date: 03-11-2023
Publisher: Springer Berlin Heidelberg
Keywords: Osteoporosis
Osteoporosis
Published in: European Spine Journal / Issue 4/2024
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI: https://doi.org/10.1007/s00586-023-08016-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prognostic nutritional index and modified frailty index, independent risk factors for recompression in elderly patients with osteoporotic vertebral compression fractures

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 4/2024

Incidence and risk factors of distal adjacent disc degeneration in adolescent idiopathic scoliosis patients undergoing fusion surgery: a systematic review and meta-analysis

History of pain around the lumbopelvic region during perinatal period: a prospective cohort study

A decade of experience in over 300 surgically treated spine patients with long-term oral anticoagulation: a propensity score matched cohort study

Letter to the Editor concerning "Virtual reality is effective in the management of chronic low back ache in adults: a systematic review and meta-analysis of randomized controlled trials" by V. Kumar et al. (Eur Spine J [2023]: doi: 10.1007/s00586-023-08040-5)

Validation of the AO Spine CROST (Clinician Reported Outcome Spine Trauma) in the clinical setting

Announcements