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01-12-2023 | Osteoporosis | Original Article

Fracture distribution in postmenopausal women: a FRISBEE sub-study

Authors: Mugisha Aude, Body Jean-Jacques, Iconaru Laura, Baleanu Felicia, Charles Alexia, Rozenberg Serge, Surquin Mureille, Bergmann Pierre, Benoit Florence

Published in: Archives of Osteoporosis | Issue 1/2023

Abstract

Summary

We registered 1336 incident-validated fractures in a prospective cohort of 3560 postmenopausal (60–85 years) Belgian women (mean follow-up of 9.1 years). The increase of fracture incidence with age varied widely depending on the fracture site and was significantly steeper for central than for peripheral fractures (e.g., not significant for the ankle).

Introduction

The epidemiology of fracture sites other than MOFs has been less studied. We examined the incidence of fractures according to their sites in a prospective cohort of postmenopausal Belgian women.

Methods

Three thousand five hundred sixty postmenopausal women, aged 60–85 years old, were recruited from 2007 to 2013 and surveyed yearly (FRISBEE). The number of validated incident fractures was recorded and analyzed in relation to age and the fracture site.

Results

One thousand three hundred thirty-six fractures were recorded after a mean follow-up of 9.1 years. Seven hundred fifty-six fractures (57%) were MOFs and 580 (43%) non-MOFs, while 813 (61%) were central and 523 (39%) peripheral. The increase of fracture incidence with age differed between fracture sites and was steeper for central than for peripheral fractures. The ratio of MOFs to non-MOFs increased significantly with age, from 1.10 (95% CI: 0.83–1.45) for the 60–69 to 1.69 [1.42–2.01] for the 80–89-year subgroup (P = 0.017). This was also true for central versus peripheral fracture.

We differentiated three groups of fracture incidence evolution with age: fractures with a mean increase/decade (compared to the 60–69 age group) of less than 1.5, 1.5–2.0, and 2.0–3.0. The lowest increase was seen for most peripheral fractures, whereas the greatest increase included hip, scapula, pelvis, ribs, and spine fractures.

Conclusion

The increase of fracture incidence with age varied widely depending on the fracture site, and the ratio of MOFs to non-MOFs rose significantly with age. Some peripheral fractures, such as the ankle, did not increase significantly with age, suggesting that bone fragility does not play a major role in their occurrence.

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Title: Fracture distribution in postmenopausal women: a FRISBEE sub-study
Authors: Mugisha Aude
Body Jean-Jacques
Iconaru Laura
Baleanu Felicia
Charles Alexia
Rozenberg Serge
Surquin Mureille
Bergmann Pierre
Benoit Florence
Publication date: 01-12-2023
Publisher: Springer London
Keywords: Osteoporosis
Osteoporosis
Published in: Archives of Osteoporosis / Issue 1/2023
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI: https://doi.org/10.1007/s11657-022-01191-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Fracture distribution in postmenopausal women: a FRISBEE sub-study

Abstract

Summary

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Summary

Introduction

Methods

Results

Conclusion

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