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Archives of Osteoporosis
Published in: Archives of Osteoporosis 1/2022

01-12-2022 | Osteoporosis | Original Article

Circulating platelet concentration is associated with bone mineral density in women

Authors: Wei-Chun Ma, Yu-Cheng Cheng, Wen-Jane Lee, Yu-Hsuan Li, I-Te Lee

Published in: Archives of Osteoporosis | Issue 1/2022

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Abstract

Summary

In this cross-sectional study, enrollment included 818 female adults undergoing bone mineral density (BMD) assessment during the health examination. Subjects with osteoporosis had the lowest circulating platelet concentrations. The circulating platelet concentration was positively correlated with BMD. A high platelet concentration had independently low odds of osteoporosis.

Purpose

Platelets play an important role in bone metabolism. However, the association between circulating platelet counts and bone mineral density (BMD) has been inconsistently reported. We aimed to investigate the relationship between platelet counts and osteoporosis in Chinese women.

Methods

In this cross-sectional study, a total of 818 female adults who underwent BMD assessment during the health examination were enrolled. Blood cell counts and biochemistry data were recorded.

Results

Subjects with osteoporosis had the lowest platelet counts (238 ± 59 × 109/L) compared with subjects with osteopenia (256 ± 64 × 109/L) and a normal BMD (269 ± 76 × 109/L, P < 0.001). The circulating platelet concentration was positively correlated with the BMD of the lumbar spine (r = 0.195, P < 0.001), left hip (r = 0.145, P < 0.001), and right hip (r = 0.149, P < 0.001). According to the receiver operating characteristic curve, the cutoff platelet concentration for differentiating osteoporosis was 260 × 109/L. A high platelet concentration had significantly low odds of osteoporosis after adjusting for other covariates (odds ratio = 0.574, 95% confidence interval: 0.346‒0.953, P = 0.032).

Conclusion

The circulating platelet concentration was significantly correlated with BMD in Chinese women.
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Metadata
Title
Circulating platelet concentration is associated with bone mineral density in women
Authors
Wei-Chun Ma
Yu-Cheng Cheng
Wen-Jane Lee
Yu-Hsuan Li
I-Te Lee
Publication date
01-12-2022
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2022
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-022-01089-7

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