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Open Access 01-11-2019 | Osteoporosis | Musculoskeletal

Bone mineral density measurements derived from dual-layer spectral CT enable opportunistic screening for osteoporosis

Authors: Ferdinand Roski, Johannes Hammel, Kai Mei, Thomas Baum, Jan S. Kirschke, Alexis Laugerette, Felix K. Kopp, Jannis Bodden, Daniela Pfeiffer, Franz Pfeiffer, Ernst J. Rummeny, Peter B. Noël, Alexandra S. Gersing, Benedikt J. Schwaiger

Published in: European Radiology | Issue 11/2019

Abstract

Objective

To investigate the in vivo applicability of non-contrast-enhanced hydroxyapatite (HA)-specific bone mineral density (BMD) measurements based on dual-layer CT (DLCT).

Methods

A spine phantom containing three artificial vertebral bodies with known HA densities was measured to obtain spectral data using DLCT and quantitative CT (QCT), simulating different patient positions and grades of obesity. BMD was calculated from virtual monoenergetic images at 50 and 200 keV. HA-specific BMD values of 174 vertebrae in 33 patients (66 ± 18 years; 33% women) were determined in non-contrast routine DLCT and compared with corresponding QCT-based BMD values.

Results

Examining the phantom, HA-specific BMD measurements were on a par with QCT measurements. In vivo measurements revealed strong correlations between DLCT and QCT (r = 0.987 [95% confidence interval, 0.963–1.000]; p < 0.001) and substantial agreement in a Bland–Altman plot.

Conclusion

DLCT-based HA-specific BMD measurements were comparable with QCT measurements in in vivo analyses. This suggests that opportunistic DLCT-based BMD measurements are an alternative to QCT, without requiring phantoms and specific protocols.

Key Points

• DLCT-based hydroxyapatite-specific BMD measurements show a substantial agreement with QCT-based BMD measurements in vivo.

• DLCT-based hydroxyapatite-specific measurements are on a par with QCT in spine phantom measurements.

• Opportunistic DLCT-based BMD measurements may be a feasible alternative for QCT, without requiring dedicated examination protocols or a phantom.

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Title: Bone mineral density measurements derived from dual-layer spectral CT enable opportunistic screening for osteoporosis
Authors: Ferdinand Roski
Johannes Hammel
Kai Mei
Thomas Baum
Jan S. Kirschke
Alexis Laugerette
Felix K. Kopp
Jannis Bodden
Daniela Pfeiffer
Franz Pfeiffer
Ernst J. Rummeny
Peter B. Noël
Alexandra S. Gersing
Benedikt J. Schwaiger
Publication date: 01-11-2019
Publisher: Springer Berlin Heidelberg
Keywords: Osteoporosis
Osteoporosis
Published in: European Radiology / Issue 11/2019
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-019-06263-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Bone mineral density measurements derived from dual-layer spectral CT enable opportunistic screening for osteoporosis

Abstract

Objective

Methods

Results

Conclusion

Key Points

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

Key Points

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