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Osteoporosis International
Published in: Osteoporosis International 8/2003

01-08-2003 | Review

Osteoporosis after solid organ and bone marrow transplantation

Authors: Adi Cohen, Elizabeth Shane

Published in: Osteoporosis International | Issue 8/2003

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Abstract

Organ transplantation has become increasingly common as a therapy for end-stage renal, liver, cardiac and pulmonary disease. The population of patients who have survived organ transplantation has grown dramatically over the last 2 decades. Although organ transplant recipients now benefit from greatly improved survival, long-term complications of organ transplantation, such as osteoporosis, adversely affect quality of life and must be addressed. In the early post-transplantation period, the effects of high dose glucocorticoids, combined with other immunosuppressive drugs such as cycosporine A and tacrolimus, cause rapid bone loss particularly at the spine and proximal femur. In this setting, fracture incidence rates as high as 25–65% have been reported. Treatment and prevention strategies must target this early post-transplant period, as well as the patient awaiting transplantation and the long-term transplant recipient. This review will discuss the clinical features of transplantation osteoporosis, the pathophysiology of post-transplantation bone loss and prevention and therapy of this unique bone disease.
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Metadata
Title
Osteoporosis after solid organ and bone marrow transplantation
Authors
Adi Cohen
Elizabeth Shane
Publication date
01-08-2003
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 8/2003
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-003-1426-z

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