Top

Published in:

01-12-2021 | Osteomalacia | Case Report

Phosphaturic Mesenchymal Tumor Masquerading as Mesenchymal Tumors with Diverse Differential Diagnosis: Series of 4 Cases with Emphasis on Histomorphological Spectrum

Authors: R. T. Rajeswarie, Akhila Lakshmikantha, S. Kannan, V. Pillai, K. Prasad

Published in: Indian Journal of Surgical Oncology | Special Issue 2/2021

Excerpt

Phosphaturic mesenchymal tumors (PMTs) are rare tumors which are associated with oncogenic osteomalacia. For many years, it has been reported that many types of tumors could be associated with osteomalacia as a paraneoplastic syndrome. In 1987, Weidner and Santa Cruz [1] made a sentinel observation that most of the tumor associated with osteomalacia showed similar and characteristic histomorphological features and termed it as “Phosphaturic mesenchymal tumor (PMT).” …

Weidner N, Santa Cruz D (1987) Phosphaturic mesenchymal tumors. A polymorphous group causing osteomalacia or rickets. Cancer 59(8):1442–1454. https://doi.org/10.1002/1097-0142(19870415)59:8<1442::AID-CNCR2820590810>3.0.CO;2-QCrossRefPubMed

Folpe AL, Fanburg-Smith JC, Billings SD, Bisceglia M, Bertoni F, Cho JY, Econs MJ, Inwards CY, Jan de Beur SM, Mentzel T, Montgomery E, Michal M, Miettinen M, Mills SE, Reith JD, O’Connell JX, Rosenberg AE, Rubin BP, Sweet DE, Vinh TN, Wold LE, Wehrli BM, White KE, Zaino RJ, Weiss SW (2004) Most osteomalacia-associated mesenchymal tumors are a single histopathologic entity: an analysis of 32 cases and a comprehensive review of the literature. Am J Surg Pathol 28(1):1–30. https://doi.org/10.1097/00000478-200401000-00001CrossRefPubMed

Shustik DA, Ng DC, Sittampalam K (2015) Phosphaturic mesenchymal tumour mixed connective tissue variant: report of three cases with unusual histological findings. Int J Clin Exp Pathol 8(6):7506–7517PubMedPubMedCentral

Agaimy A, Michal M, Chiosea S, Petersson F, Hadravsky L, Kristiansen G, Horch RE, Schmolders J, Hartmann A, Haller F, Michal M (2017) Clinicopathologic, immunohistochemical and molecular analysis of 22 cases expanding their morphologic and immunophenotypic spectrum. Am J Surg Pathol 41(10):1371–1380. https://doi.org/10.1097/PAS.0000000000000890CrossRefPubMed

David K, Revesz T, Kratimenos G, Krausz T, Crockard HA (1996) Oncogenic osteomalacia associated with a meningeal phosphaturic mesenchymal tumor: case report. J Neurosurg 84(2):288–292. https://doi.org/10.3171/jns.1996.84.2.0288CrossRefPubMed

Puthenveetil PJ, Hattab EM, Peacock M, Horn EM (2013) Thoracic phosphaturic mesenchymal tumors causing oncogenic osteomalacia. J Clin Neurosci 20(8):1057–1061. https://doi.org/10.1016/j.jocn.2012.09.035CrossRefPubMed

Shiba E, Matsuyama A, Shibuya R, Yabuki K, Harada H, Nakamoto M, Kasai T, Hisaoka M (2016) Immunohistochemical and molecular detection of the expression of FGF23 in phosphaturic mesenchymal tumors including the non-phosphaturic variant. Diagn Pathol 11:26. https://doi.org/10.1186/s13000-016-0477-3CrossRefPubMedPubMedCentral

Cai Q, Hodgson SF, Kao PC, Lennon VA, Klee GG, Zinsmiester AR, Kumar R (1994) Brief report: inhibition of renal phosphate transport by a tumor product in a patient with oncogenic osteomalacia. N Engl J Med 330(23):1645–1649. https://doi.org/10.1056/NEJM199406093302304CrossRefPubMed

Jonsson KB, Zahradnik R, Larsson T, White KE, Sugimoto T, Imanishi Y, Yamamoto T, Hampson G, Koshiyama H, Ljunggren Ö, Oba K, Yang IM, Miyauchi A, Econs MJ, Lavigne J, Jüppner H (2003) Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med 348(17):1656–1663. https://doi.org/10.1056/NEJMoa020881CrossRef

10.

Ledford CK, Zelenski NA, Cardona DM, Brigman BE, Eward WC (2013) The phosphaturic mesenchymal tumor: why is definitive diagnosis and curative surgery often delayed? Clin Orthop Relat Res 471(11):3618–3625. https://doi.org/10.1007/s11999-013-3178-1CrossRefPubMedPubMedCentral

Title: Phosphaturic Mesenchymal Tumor Masquerading as Mesenchymal Tumors with Diverse Differential Diagnosis: Series of 4 Cases with Emphasis on Histomorphological Spectrum
Authors: R. T. Rajeswarie
Akhila Lakshmikantha
S. Kannan
V. Pillai
K. Prasad
Publication date: 01-12-2021
Publisher: Springer India
Keywords: Osteomalacia
Osteomalacia
Published in: Indian Journal of Surgical Oncology / Issue Special Issue 2/2021
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI: https://doi.org/10.1007/s13193-021-01321-9

At a glance: The STEP trials

Springer Medicine

Phosphaturic Mesenchymal Tumor Masquerading as Mesenchymal Tumors with Diverse Differential Diagnosis: Series of 4 Cases with Emphasis on Histomorphological Spectrum

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Special Issue 2/2021

Upper Aerodigestive Tract Endoscopy During COVID-19

The COVID-19 Pandemic and Cancer Surgery

Does Preoperative Diagnosis Will Change the Treatment Plan of Clear Cell Carcinoma of Endometrium Masquerading as Desmoid Tumor of Anterior Abdominal Wall?: a Case Report

Elective Surgical Experience During COVID Pandemic at a Tertiary Cancer Care Centre in India: A Retrospective Analysis

Head and Neck Surgery During COVID-19 Pandemic: Experience from a Tertiary Care in India

Analysis of Early Impact of COVID-19 on Presentation and Management of Oral Cancers – an Experience from a Tertiary Care Hospital in South India