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01-06-2009 | Original Paper

Osteogenic abilities of bone marrow stromal cells are not defective in patients with osteonecrosis

Authors: Jeong Joon Yoo, Won Seok Song, Kyung-Hoi Koo, Kang Sup Yoon, Hee Joong Kim

Published in: International Orthopaedics | Issue 3/2009

Abstract

We investigated whether the proliferation activities and osteogenic capacities of bone marrow stromal cells (BMSCs) are depressed in patients with osteonecrosis of the femoral head (ONFH). BMSCs were isolated from fresh bone marrow of the iliac crests of 54 donors and were differentiated into osteogenic lineage in vitro. The results of 27 consecutive patients with ONFH (16 idiopathic and 11 alcohol-induced) were compared with those of 27 patients with a nonnecrotic hip disorder. The proliferative activities of BMSCs in patients with ONFH were not found to be reduced and their osteogenic capacities (alkaline phosphatase activity and calcium deposition amount) were unaltered during in vitro differentiation. Results from patients with idiopathic or alcohol-induced ONFH were similar to those of matched patients with nonnecrotic disorder. These findings suggest that the osteogenic potentials of BMSCs are not defective in patients with ONFH.

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Title: Osteogenic abilities of bone marrow stromal cells are not defective in patients with osteonecrosis
Authors: Jeong Joon Yoo
Won Seok Song
Kyung-Hoi Koo
Kang Sup Yoon
Hee Joong Kim
Publication date: 01-06-2009
Publisher: Springer-Verlag
Published in: International Orthopaedics / Issue 3/2009
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-008-0524-0

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Osteogenic abilities of bone marrow stromal cells are not defective in patients with osteonecrosis

Abstract

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Abstract

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