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Trials
Published in: Trials 1/2024

Open Access 01-12-2024 | Osteoarthrosis | Study protocol

Nutrition and movement to improve quality of life in patients with knee osteoarthritis: the NUMOQUA study protocol for a randomised controlled trial

Authors: Elisabeth Höld, Sabine Chmelar, Tatjana Aubram, Gabriele Leitner, Stefan Nehrer, Oliver Neubauer, Karl-Heinz Wagner, Barbara Wondrasch

Published in: Trials | Issue 1/2024

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Abstract

Background

Osteoarthritis (OA) has long been considered as a degenerative disease of cartilage tissue resulting from bodily wear and tear. However, there is accumulating evidence that inflammation plays a key role in the pathogenesis of OA. In knee OA, the most common form of OA, exercise therapy as an effective component of early treatment addresses functional deficits, pain and inflammation. Since inflammation is critical for the development and progress of OA, anti-inflammatory therapies must be combined strategically.
In the course of the NUMOQUA project, an anti-inflammatory therapeutic diet named ‘Austrian Osteoarthritis Cuisine’ was developed. It is based on the framework of the New Nordic Diet combined with the food-based dietary guidelines of Austria, the guidelines for OA, the Austrian food culture and the principles of a sustainable diet. The present study examines the implementation of the ‘Austrian OA Cuisine’ combined with the evidence-based training programme GLA:D® (Good Life with osteoArthritis in Denmark) in Austrian patients with knee OA and the effects on quality of life, nutritional and inflammatory status, as well as oxidative stress parameters.

Methods

A total of 60 participants aged 50 to 75 with knee OA will be included and randomly assigned either to the intervention group or the control group. All participants will undergo the GLA:D® programme in the first 6 weeks. Additionally, the intervention group will receive nutritional group training and individual nutritional counselling on the ‘Austrian OA Cuisine’ over 9 months. The control group will receive general information about a healthy lifestyle. Measurements at baseline and at 4 follow-up dates include nutritional, inflammatory and oxidative stress markers. Furthermore, anthropometric, behavioural and clinical data will be obtained. The recruitment process lasted from autumn 2022 to January 2024, followed by the intervention until October 2024.

Discussion

The prevalence of OA is expected to increase in the future due to ongoing demographic changes and rising obesity rates. The expected results will provide important evidence on whether this interdisciplinary therapeutic approach could be a new, cost-effective and sustainable strategy to address the disease process of OA without negative side effects.

Trial registration

ClinicalTrials.gov NCT05955300. Date of registration: 23rd of October 2023.
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Metadata
Title
Nutrition and movement to improve quality of life in patients with knee osteoarthritis: the NUMOQUA study protocol for a randomised controlled trial
Authors
Elisabeth Höld
Sabine Chmelar
Tatjana Aubram
Gabriele Leitner
Stefan Nehrer
Oliver Neubauer
Karl-Heinz Wagner
Barbara Wondrasch
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Trials / Issue 1/2024
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-024-08048-2

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