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01-02-2022 | Osteoarthrosis | Original Article

Photobiomodulation and Sida tuberculata combination declines the inflammation’s markers in knee-induced osteoarthritis

Authors: Eloá Ferreira Yamada, Carolina dos Santos Stein, Rafael Noal Moresco, Franciane Bobinski, Juliete Palandi, Paula Franson Fernandes, Vanderlei Folmer, Morgana Duarte da Silva

Published in: Lasers in Medical Science | Issue 1/2022

Abstract

The aim of this study was to assess potential combination effects of photobiomodulation therapy (PBMT) with Sida tuberculata extracts on the oxidative stress and antioxidant activity, as well as on the inflammatory process. Rats with knee osteoarthritis (OA) were treated with S. tuberculata extracts and PBMT (904 nm, 18 J/cm²). The animals were evaluated for nociception and edema. The blood, knee lavage and structures, spinal cord, and brainstem were collected for biochemical analyses (lipid peroxidation, protein carbonyl content, superoxide dismutase activity, non-protein thiol levels, and measurement of nitrite/nitrate). The knee structures were also used to measure cytokine levels. PBMT lowered the damage due to oxidative stress in the knee and at distant sites from the lesion. PBMT also reduced the levels of nitric oxide and cytokines, which could explain the nociception reduction mechanism. Similarly, S. tuberculata decreased the damage by oxidative stress, levels of nitrite/nitrate, and cytokines. The therapy combination reduced levels of cytokines and nitrite/nitrate. PBMT and S. tuberculata extracts reduced the oxidative stress and inflammation. It is noteworthy that PBMT increased the antioxidant activity in the knee and at sites distant from the lesion, contributing to a more significant decrease in nociception. The combination of therapies did not present significant effects on the analyzed parameters. Therefore, it is suggested that PBM is sufficient to minimize the signs and symptoms of the knee OA in our rat model.

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Title: Photobiomodulation and Sida tuberculata combination declines the inflammation’s markers in knee-induced osteoarthritis
Authors: Eloá Ferreira Yamada
Carolina dos Santos Stein
Rafael Noal Moresco
Franciane Bobinski
Juliete Palandi
Paula Franson Fernandes
Vanderlei Folmer
Morgana Duarte da Silva
Publication date: 01-02-2022
Publisher: Springer London
Keywords: Osteoarthrosis
Nitrate
Diclofenac
Osteoarthrosis
Cytokines
Published in: Lasers in Medical Science / Issue 1/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-03207-8

Keynote webinar | Spotlight on medication adherence

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Photobiomodulation and Sida tuberculata combination declines the inflammation’s markers in knee-induced osteoarthritis

Abstract

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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