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Open Access 01-12-2019 | Osteoarthritis of the Hip | Review

Prognostic factors for progression of osteoarthritis of the hip: a systematic review

Authors: C. H. Teirlinck, D. M. J. Dorleijn, P. K. Bos, J. B. M. Rijkels-Otters, S. M. A. Bierma-Zeinstra, P. A. J. Luijsterburg

Published in: Arthritis Research & Therapy | Issue 1/2019

Abstract

Background

Predicting which patients with hip osteoarthritis are more likely to show disease progression is important for healthcare professionals. Therefore, the aim of this review was to assess which factors are predictive of progression in patients with hip osteoarthritis.

Methods

A literature search was made up until 14 March 2019. Included were cohort and case-control studies evaluating the association between factors and progression (either clinical, radiological, or THR). Excluded were studies with a follow-up < 1 year or specific underlying pathologies of osteoarthritis. Risk of bias was assessed using the QUIPS tool. A best-evidence synthesis was conducted.

Results

We included 57 articles describing 154 different factors. Of these, a best-evidence synthesis was possible for 103 factors, separately for clinical and radiological progression, and progression to total hip replacement. We found strong evidence for more clinical progression in patients with comorbidity and more progression to total hip replacement for a higher Kellgren and Lawrence grade, superior or (supero) lateral femoral head migration, and subchondral sclerosis. Strong evidence for no association was found regarding clinical progression for gender, social support, pain medication, quality of life, and limited range of motion of internal rotation or external rotation. Also, strong evidence for no association was found regarding radiological progression for the markers CTX-I, COMP, NTX-I, PINP, and PIIINP and regarding progression to total hip replacement for body mass index.

Conclusion

Strong evidence suggested that 4 factors were predictive of progression of hip osteoarthritis, whereas 12 factors were not predictive of progression. Evidence for most of the reported factors was either limited or conflicting.

Protocol registration

PROSPERO, CRD42015010757

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Litwic A, Edwards MH, Dennison EM, Cooper C. Epidemiology and burden of osteoarthritis. Br Med Bull. 2013;105:185–99.CrossRef

Lievense AM, Bierma-Zeinstra SM, Verhagen AP, Verhaar JA, Koes BW. Prognostic factors of progress of hip osteoarthritis: a systematic review. Arthritis Rheum. 2002;47(5):556–62.CrossRef

Wright AA, Cook C, Abbott JH. Variables associated with the progression of hip osteoarthritis: a systematic review. Arthritis Rheum. 2009;61(7):925–36.CrossRef

de Rooij M, van der Leeden M, Heymans MW, Holla JF, Hakkinen A, Lems WF, Roorda LD, Veenhof C, Sanchez-Ramirez DC, de Vet HC, et al. Course and predictors of pain and physical functioning in patients with hip osteoarthritis: systematic review and meta-analysis. J Rehabil Med. 2016;48(3):245–52.CrossRef

Hayden JA, Cote P, Bombardier C. Evaluation of the quality of prognosis studies in systematic reviews. Ann Intern Med. 2006;144(6):427–37.CrossRef

Altman RD, Bloch DA, Dougados M, Hochberg M, Lohmander S, Pavelka K, Spector T, Vignon E. Measurement of structural progression in osteoarthritis of the hip: the Barcelona consensus group. Osteoarthr Cartilage. 2004;12(7):515–24.CrossRef

Hayden JA, van der Windt DA, Cartwright JL, Cote P, Bombardier C. Assessing bias in studies of prognostic factors. Ann Intern Med. 2013;158(4):280–6.CrossRef

Huguet A, Hayden JA, Stinson J, McGrath PJ, Chambers CT, Tougas ME, Wozney L. Judging the quality of evidence in reviews of prognostic factor research: adapting the GRADE framework. Syst Rev. 2013;2:71.CrossRef

Davis P, Hayden J, Springer J, Bailey J, Molinari M, Johnson P. Prognostic factors for morbidity and mortality in elderly patients undergoing acute gastrointestinal surgery: a systematic review. Can J Surg. 2014;57(2):E44–52.PubMedPubMedCentral

10.

Ernster VL. Nested case-control studies. Prev Med. 1994;23(5):587–90.CrossRef

11.

Agricola R, Reijman M, Bierma-Zeinstra SMA, Verhaar JAN, Weinans H, Waarsing JH. Total hip replacement but not clinical osteoarthritis can be predicted by the shape of the hip: a prospective cohort study (CHECK). Osteoarthr Cartilage. 2013;21(4):559–64.CrossRef

12.

Agricola R, Leyland KM, Bierma-Zeinstra SM, Thomas GE, Emans PJ, Spector TD, Weinans H, Waarsing JH, Arden NK. Validation of statistical shape modelling to predict hip osteoarthritis in females: data from two prospective cohort studies (Cohort Hip and Cohort Knee and Chingford). Rheumatology (Oxford). 2015;54(11):2033–41.CrossRef

13.

Auquier L, Paolaggi JB, Cohen De Lara A. Long term evolution of pain in a series of 273 coxarthrosis. Rev Rhum Mal Osteo-Articul. 1979;46(3):153–62.

14.

Barr RJ, Gregory JS, Reid DM, Aspden RM, Yoshida K, Hosie G, Silman AJ, Alesci S, Macfarlane GJ. Predicting OA progression to total hip replacement: can we do better than risk factors alone using active shape modelling as an imaging biomarker? Rheumatology (Oxford). 2012;51(3):562–70.CrossRef

15.

Bastick AN, Verkleij SPJ, Damen J, Wesseling J, Hilberdink WKHA, Bindels PJE, Bierma-Zeinstra SMA. Defining hip pain trajectories in early symptomatic hip osteoarthritis - 5 year results from a nationwide prospective cohort study (CHECK). Osteoarthr Cartil. 2016;24(5):768–75.CrossRef

16.

Bastick AN, Damen J, Agricola R, Brouwer RW, Bindels PJ, Bierma-Zeinstra SM. Characteristics associated with joint replacement in early symptomatic knee or hip osteoarthritis: 6-year results from a nationwide prospective cohort study (CHECK). Br J Gen Pract. 2017;67(663):e724–31.CrossRef

17.

Bergink AP, Zillikens MC, Van Leeuwen JPTM, Hofman A, Uitterlinden AG, van Meurs JBJ. 25-Hydroxyvitamin D and osteoarthritis: a meta-analysis including new data. Semin Arthritis Rheum. 2016;45(5):539–46.CrossRef

18.

Birn J, Pruente R, Avram R, Eyler W, Mahan M, van Holsbeeck M. Sonographic evaluation of hip joint effusion in osteoarthritis with correlation to radiographic findings. J Clin Ultrasound. 2014;42(4):205–11.CrossRef

19.

Birrell F, Afzal C, Nahit E, Lunt M, Macfarlane GJ, Cooper C, Croft PR, Hosie G, Silman AJ. Predictors of hip joint replacement in new attenders in primary care with hip pain. Br J Gen Pract. 2003;53(486):26–30.PubMedPubMedCentral

20.

Bouyer B, Mazieres B, Guillemin F, Bouttier R, Fautrel B, Morvan J, Pouchot J, Rat AC, Roux CH, Verrouil E, et al. Association between hip morphology and prevalence, clinical severity and progression of hip osteoarthritis over 3 years: the knee and hip osteoarthritis long-term assessment cohort results. Jt Bone Spine. 2016;83(4):432–8.CrossRef

21.

Castano Betancourt MC, Van der Linden JC, Rivadeneira F, Rozendaal RM, Bierma Zeinstra SM, Weinans H, Waarsing JH. Dual energy x-ray absorptiometry analysis contributes to the prediction of hip osteoarthritis progression. Arthritis Res Ther. 2009;11(6):R162.CrossRef

22.

Chaganti RK, Kelman A, Lui L, Yao W, Javaid MK, Bauer D, Nevitt M, Lane NE, for the Study of Osteoporotic Fractures Research G. Change in serum measurements of cartilage oligomeric matrix protein and association with the development and worsening of radiographic hip osteoarthritis. Osteoarthr Cartilage. 2008;16(5):566–71.CrossRef

23.

Chevalier X, Conrozier T, Gehrmann M, Claudepierre P, Mathieu P, Unger S, Vignon E. Tissue inhibitor of metalloprotease-1 (TIMP-1) serum level may predict progression of hip osteoarthritis. Osteoarthr Cartilage. 2001;9(4):300–7.CrossRef

24.

Conrozier T, Chappuis-Cellier C, Richard M, Mathieu P, Richard S, Vignon E. Increased serum C-reactive protein levels by immunonephelometry in patients with rapidly destructive hip osteoarthritis. Rev Rhum Engl Ed. 1998;65(12):759–65.PubMed

25.

Conrozier T, Jousseaume CA, Mathieu P, Tron AM, Caton J, Bejui J, Vignon E. Quantitative measurement of joint space narrowing progression in hip osteoarthritis: a longitudinal retrospective study of patients treated by total hip arthroplasty. Br J Rheumatol. 1998;37(9):961–8.CrossRef

26.

Conrozier T, Saxne T, Fan CSS, Mathieu P, Tron AM, Heinegard D, Vignon E. Serum concentrations of cartilage oligomeric matrix protein and bone sialoprotein in hip osteoarthritis: a one year prospective study. Ann Rheum Dis. 1998;57(9):527–32.CrossRef

27.

Danielsson LG. Incidence and prognosis of coxarthrosis. Acta Orthop Scand Suppl. 1964;66(SUPPL 66):61–114.

28.

Danielsson LG. Incidence and prognosis of coxarthrosis. Clin Orthop Relat Res. 1993;287:13–8.

29.

van Dijk GM, Veenhof C, Spreeuwenberg P, Coene N, Burger BJ, van Schaardenburg D, van den Ende CH, Lankhorst GJ, Dekker J. Prognosis of limitations in activities in osteoarthritis of the hip or knee: a 3-year cohort study. Arch Phys Med Rehabil. 2010;91(1):58–66.CrossRef

30.

Van Dijk GM, Veenhof C, Lankhorst GJ, Van Den Ende CH, Dekker J. Vitality and the course of limitations in activities in osteoarthritis of the hip or knee. BMC Musculoskelet Disord. 2011;12:269.CrossRef

31.

Dorleijn DMJ, Luijsterburg PAJ, Bay-Jensen AC, Siebuhr AS, Karsdal MA, Rozendaal RM, Bos PK, Bierma-Zeinstra SMA. Association between biochemical cartilage markers and clinical symptoms in patients with hip osteoarthritis: cohort study with 2-year follow-up. Osteoarthr Cartilage. 2015;23(1):57–62.CrossRef

32.

Dougados M, Gueguen A, Nguyen M, Berdah L, Lequesne M, Mazieres B, Vignon E. Radiological progression of hip osteoarthritis: definition, risk factors and correlations with clinical status. Ann Rheum Dis. 1996;55(6):356–62.CrossRef

33.

Dougados M, Gueguen A, Nguyen M, Berdah L, Lequesne M, Mazieres B, Vignon E. Radiographic features predictive of radiographic progression of hip osteoarthritis. Rev Rhum Engl Ed. 1997;64(12):795–803.PubMed

34.

Dougados M, Gueguen A, Nguyen M, Berdah L, Lequesne M, Mazieres B, Vignon E. Requirement for total hip arthroplasty: an outcome measure of hip osteoarthritis? J Rheumatol. 1999;26(4):855–61.PubMed

35.

Fukushima K, Inoue G, Uchida K, Fujimaki H, Miyagi M, Nagura N, Uchiyama K, Takahira N, Takaso M. Relationship between synovial inflammatory cytokines and progression of osteoarthritis after hip arthroscopy. Exp Assess. J Orthop Surg. 2018;26(2):1-6.

36.

Golightly YM, Allen KD, Helmick CG, Schwartz TA, Renner JB, Jordan JM. Hazard of incident and progressive knee and hip radiographic osteoarthritis and chronic joint symptoms in individuals with and without limb length inequality. J Rheumatol. 2010;37(10):2133–40.CrossRef

37.

Gossec L, Tubach F, Baron G, Ravaud P, Logeart I, Dougados M. Predictive factors of total hip replacement due to primary osteoarthritis: a prospective 2 year study of 505 patients. Ann Rheum Dis. 2005;64(7):1028–32.CrossRef

38.

Hartofilakidis G, Karachalios T. Idiopathic osteoarthritis of the hip: incidence, classification, and natural history of 272 cases. Orthopedics. 2003;26(2):161–6.PubMed

39.

Hawker GA, Guan J, Croxford R, Coyte PC, Glazier RH, Harvey BJ, Wright JG, Williams JI, Badley EM. A prospective population-based study of the predictors of undergoing total joint arthroplasty. Arthritis Rheum. 2006;54(10):3212–20.CrossRef

40.

Hoeven TA, Kavousi M, Clockaerts S, Kerkhof HJM, Van Meurs JB, Franco O, Hofman A, Bindels P, Witteman J, Bierma-Zeinstra S. Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study. Ann Rheum Dis. 2013;72(5):646–51.CrossRef

41.

Holla JFM, Steultjens MPM, Roorda LD, Heymans MW, Ten Wolde S, Dekker J. Prognostic factors for the two-year course of activity limitations in early osteoarthritis of the hip and/or knee. Arthritis Care Res. 2010;62(10):1415–25.CrossRef

42.

Juhakoski R, Malmivaara A, Lakka TA, Tenhonen S, Hannila ML, Arokoski JP. Determinants of pain and functioning in hip osteoarthritis - a two-year prospective study. Clin Rehabil. 2013;27(3):281–7.CrossRef

43.

Kalyoncu U, Gossec L, Nguyen M, Berdah L, Mazieres B, Lequesne M, Dougados M. Self-reported prevalence of psoriasis and evaluation of the impact on the natural history of hip osteoarthritis: results of a 10 years follow-up study of 507 patients (ECHODIAH study). Jt Bone Spine. 2009;76(4):389–93.CrossRef

44.

Kelman A, Lui L, Yao W, Krumme A, Nevitt M, Lane NE. Association of higher levels of serum cartilage oligomeric matrix protein and N-telopeptide crosslinks with the development of radiographic hip osteoarthritis in elderly women. Arthritis Rheum. 2006;54(1):236–43.CrossRef

45.

Kerkhof HJM, Bierma-Zeinstra SMA, Castano-Betancourt MC, De Maat MP, Hofman A, Pols HAP, Rivadeneira F, Witteman JC, Uitterlinden AG, Van Meurs JBJ. Serum C reactive protein levels and genetic variation in the CRP gene are not associated with the prevalence, incidence or progression of osteoarthritis independent of body mass index. Ann Rheum Dis. 2010;69(11):1976–82.CrossRef

46.

Kopec JA, Sayre EC, Schwartz TA, Renner JB, Helmick CG, Badley EM, Cibere J, Callahan LF, Jordan JM. Occurrence of radiographic osteoarthritis of the knee and hip among african americans and whites: a population-based prospective cohort study. Arthritis Care Res. 2013;65(6):928–35.CrossRef

47.

Lane NE, Nevitt MC, Hochberg MC, Hung YY, Palermo L. Progression of radiographic hip osteoarthritis over eight years in a community sample of elderly white women. Arthritis Rheum. 2004;50(5):1477–86.CrossRef

48.

Lane NE, Nevitt MC, Lui LY, De Leon P, Corr M. Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum. 2007;56(10):3319–25.CrossRef

49.

Laslett LL, Quinn S, Burgess JR, Parameswaran V, Winzenberg TM, Jones G, Ding C. Moderate vitamin D deficiency is associated with changes in knee and hip pain in older adults: a 5-year longitudinal study. Ann Rheum Dis. 2014;73(4):697–703.CrossRef

50.

Ledingham J, Dawson S, Preston B, Milligan G, Doherty M. Radiographic progression of hospital referred osteoarthritis of the hip. Ann Rheum Dis. 1993;52(4):263–7.CrossRef

51.

Lievense AM, Koes BW, Verhaar JAN, Bohnen AM, Bierma-Zeinstra SMA. Prognosis of hip pain in general practice: a prospective followup study. Arthritis Care Res. 2007;57(8):1368–74.CrossRef

52.

Maillefert JF, Gueguen A, Monreal M, Nguyen M, Berdah L, Lequesne M, Mazieres B, Vignon E, Dougados M. Sex differences in hip osteoarthritis: results of a longitudinal study in 508 patients. Ann Rheum Dis. 2003;62(10):931–4.CrossRef

53.

Mazieres B, Garnero P, Gueguen A, Abbal M, Berdah L, Lequesne M, Nguyen M, Salles JP, Vignon E, Dougados M. Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH* cohort. Ann Rheum Dis. 2006;65(3):354–9.CrossRef

54.

Nelson AE, Golightly YM, Kraus VB, Stabler T, Renner JB, Helmick CG, Jordan JM. Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project. Osteoarthr Cartilage. 2010;18(6):825–9.CrossRef

55.

Perry GH, Smith MJ, Whiteside CG. Spontaneous recovery of the joint space in degenerative hip disease. Ann Rheum Dis. 1972;31(6):440–8.CrossRef

56.

Peters TJ, Sanders C, Dieppe P, Donovan J. Factors associated with change in pain and disability over time: a community-based prospective observational study of hip and knee osteoarthritis. Br J Gen Pract. 2005;55(512):205–11.PubMedPubMedCentral

57.

Pisters MF, Veenhof C, van Dijk GM, Heymans MW, Twisk JWR, Dekker J. The course of limitations in activities over 5 years in patients with knee and hip osteoarthritis with moderate functional limitations: risk factors for future functional decline. Osteoarthr Cartilage. 2012;20(6):503–10.CrossRef

58.

Pollard TCB, Batra RN, Judge A, Watkins B, McNally EG, Gill HS, Arden NK, Carr AJ. Genetic predisposition to the presence and 5-year clinical progression of hip osteoarthritis. Osteoarthr Cartilage. 2012;20(5):368–75.CrossRef

59.

Reijman M, Hazes JMW, Bierma-Zeinstra SMA, Koes BW, Christgau S, Christiansen C, Uitterlinden AG, Pols HAP. A new marker for osteoarthritis: cross-sectional and longitudinal approach. Arthritis Rheum. 2004;50(8):2471–8.CrossRef

60.

Reijman M, Hazes JMW, Pols H, Bernsen RMD, Koes BW, Bierma-Zeinstra SMA. Role of radiography in predicting progression of osteoarthritis of the hip: prospective cohort study. Br Med J. 2005;330(7501):1183–5.CrossRef

61.

Reijman M, Pols HAP, Bergink AP, Hazes JMW, Belo JN, Lievense AM, Bierma-Zeinstra SMA. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis. 2007;66(2):158–62.CrossRef

62.

Solignac M. Biological markers of osteoarthritis: data from the ECHODIAH cohort. Presse Med. 2004;33(9 Pt 2):S13–5.PubMed

63.

Van Spil WE, Welsing PM, Bierma-Zeinstra SM, Bijlsma JW, Roorda LD, Cats HA, Lafeber FP. The ability of systemic biochemical markers to reflect presence, incidence, and progression of early-stage radiographic knee and hip osteoarthritis: data from CHECK. Osteoarthr Cartilage. 2015;23(8):1388–97.CrossRef

64.

Thompson NW, Corr AM, Geddis CJ, O’Brien S, Beverland DE. Rapidly progressive osteoarthrosis of the hip. HIP Int. 2004;14(4):217–22.CrossRef

65.

Tron AM, Conrozier T, Mathieu P, Vignon E. [Rate of joint space pinching in coxarthrosis] Vitesse de pincement de l’interligne articulaire dans la coxarthrose. Rev Rhum Ed Fr. 1994;61(9 Pt 2):124S–30S.PubMed

66.

Verkleij SPJ, Hoekstra T, Rozendaal RM, Waarsing JH, Koes BW, Luijsterburg PAJ, Bierma-Zeinstra SMA. Defining discriminative pain trajectories in hip osteoarthritis over a 2-year time period. Ann Rheum Dis. 2012;71(9):1517–23.CrossRef

67.

Vinciguerra C, Gueguen A, Revel M, Heuleu JN, Amor B, Dougados M. Predictors of the need for total hip replacement in patients with osteoarthritis of the hip. Rev Rhum Engl Ed. 1995;62(9):563–70.PubMed

Title: Prognostic factors for progression of osteoarthritis of the hip: a systematic review
Authors: C. H. Teirlinck
D. M. J. Dorleijn
P. K. Bos
J. B. M. Rijkels-Otters
S. M. A. Bierma-Zeinstra
P. A. J. Luijsterburg
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Osteoarthritis of the Hip
Osteoarthrosis
Hip-TEP
Hip-TEP
Osteoarthrosis
Osteoarthritis of the Hip
Published in: Arthritis Research & Therapy / Issue 1/2019
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/s13075-019-1969-9

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