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Experimental Hematology & Oncology
Published in: Experimental Hematology & Oncology 1/2018

Open Access 01-12-2018 | Review

Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine

Authors: Hanxiao Xu, Ying Jiao, Shuang Qin, Weiheng Zhao, Qian Chu, Kongming Wu

Published in: Experimental Hematology & Oncology | Issue 1/2018

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Abstract

Organoid technology bridges the gap between conventional two-dimensional cell line culture and in vivo models. The near-physiological technology can virtually recapitulates organ development and human diseases, such as infectious diseases, genetic abnormality and even cancers. In addition, organoids can more accurately predict drug responses, and serve as an excellent platform for drug development, including efficacy evaluation, toxicity testing and pharmacokinetics analysis. Furthermore, organoids can also be exploited to explore the possible optimized treatment strategies for each individual patient. Besides, organoid technology is a promising strategy for regeneration medicine and transplantation use, which can overcome the deficiency in the supply of healthy donor tissues and inherent immunological rejection through establishing isogenic organoids from minuscule amounts of patient biopsies. Collectively, organoids hold enormous potential for clinical applications and bring basic research closer to clinical practice. In this review, we described common organoid lines, summarized the potential clinical applications, and outlined the current limitations.
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Metadata
Title
Organoid technology in disease modelling, drug development, personalized treatment and regeneration medicine
Authors
Hanxiao Xu
Ying Jiao
Shuang Qin
Weiheng Zhao
Qian Chu
Kongming Wu
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Experimental Hematology & Oncology / Issue 1/2018
Electronic ISSN: 2162-3619
DOI
https://doi.org/10.1186/s40164-018-0122-9

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