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Open Access 23-02-2023 | Literatur kommentiert

Organerhaltende Therapie des muskelinvasiven Blasenkarzinoms: 10-Jahres-Daten der britischen BC2001-Studie

Authors: Felix Grabenbauer, Michael Flentje

Published in: Strahlentherapie und Onkologie | Issue 4/2023

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BC2001, die größte randomisierte Studie zur organerhaltenden Behandlung des muskelinvasiven Blasenkarzinoms (MIBC), zeigte eine Verbesserung in der lokoregionären Tumorkontrolle durch Hinzunahme von 5‑Fluorouracil (5-FU) und Mitomycin C (MMC) zur Bestrahlung. Die 5‑Jahres-Daten wurden bereits 2012 im N Engl J Med publiziert [1]. Die aktuelle Publikation betrifft Langzeitdaten mit 10-Jahres-Follow-up [2]. …

James ND, Hussain SA, Hall E et al (2012) Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer. N Engl J Med 366:1477–1488CrossRefPubMed

Hall E, Hussain SA, Porta N et al (2022) Chemoradiotherapy in muscle-invasive bladder cancer: 10-yr follow-up of the phase 3 randomised controlled BC2001 trial. Eur Urol 82:273–279CrossRefPubMed

Gschwend JE, Heck MM, Lehmann J et al (2019) Extended versus limited lymph node dissection in bladder cancer patients undergoing radical cystectomy: survival results from a prospective, randomized trial. Eur Urol 75:604–611CrossRefPubMed

Tyritzis SI, Hosseini A, Collins J et al (2013) Oncologic, functional, and complications outcomes of robot-assisted radical cystectomy with totally intracorporeal neobladder diversion. Eur Urol 64:734–741CrossRefPubMed

Kessler TM, Burkhard FC, Studer UE (2005) Clinical indications and outcomes with nerve-sparing cystectomy in patients with bladder cancer. Urol Clin North Am 32:165–175CrossRefPubMed

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Mak RH, Hunt D, Shipley WU et al (2014) Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233. J Clin Oncol 32:3801–3809CrossRefPubMedPubMedCentral

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Coppin CM, Gospodarowicz MK, James K et al (1996) Improved local control of invasive bladder cancer by concurrent cisplatin and preoperative or definitive radiation. The National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 14:2901–2907CrossRefPubMed

10.

Choudhury A, Porta N, Hall E et al (2021) Hypofractionated radiotherapy in locally advanced bladder cancer: an individual patient data meta-analysis of the BC2001 and BCON trials. Lancet Oncol 22:246–255CrossRefPubMedPubMedCentral

11.

Schmid SC, Schiller K, Lewerich J et al (2022) Abstract LBA75—RACE IT: a prospective, single arm, multicenter, phase II-trial to assess safety and efficacy of preoperative RAdiation therapy before radical CystEctomy combined with ImmunoTherapy in locally advanced urothelial carcinoma of the bladder (AB 65/18)—first results. Ann Oncol 33(suppl_7):S808–S869

Title: Organerhaltende Therapie des muskelinvasiven Blasenkarzinoms: 10-Jahres-Daten der britischen BC2001-Studie
Authors: Felix Grabenbauer
Michael Flentje
Publication date: 23-02-2023
Publisher: Springer Berlin Heidelberg
Published in: Strahlentherapie und Onkologie / Issue 4/2023
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI: https://doi.org/10.1007/s00066-023-02052-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Organerhaltende Therapie des muskelinvasiven Blasenkarzinoms: 10-Jahres-Daten der britischen BC2001-Studie

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

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