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Pathology & Oncology Research
Published in: Pathology & Oncology Research 2/2008

01-06-2008 | Brief Communication

Orbital Tumour as Initial Manifestation of Acute Myeloid Leukemia: Granulocytic Sarcoma: Case Report

Authors: Erika Maka, Olga Lukáts, Jeannette Tóth, Sándor Fekete

Published in: Pathology & Oncology Research | Issue 2/2008

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Abstract

We report orbital involvement as an initial manifestation of acute myeloid leukemia in a 57-year-old woman. The patient presented with painful proptosis and limited ocular motility. Orbital computed tomography revealed bilateral homogeneous masses. Orbital biopsy was performed on the right side; and histopathology disclosed a myelocytic tumour. Despite treatment using irradiation and chemotherapy, the patient died eleven months after presentation. There appear to be only a few previous reports of acute myeloid leukemia cases presenting with orbital involvement, and most cases occurred in children. This very rare condition has a poor survival prognosis, even with radiation treatment and chemotherapy.
Literature
1.
Zimmerman LE, Font RL (1975) Ophthalmologic manifestations of granulocytic sarcoma (myeloid sarcoma or chloroma). Am J Ophthalmol 80:975–989PubMed
2.
Bhattacharjee K, Bhattacharjee H, Das D, Babu K, Mahesh L, Krishnakumar S, Biswas J (2003) Chloroma of the orbit in a non-leukemic adult: a case report. Orbit 22:293–297PubMedCrossRef
3.
Kincaid MC, Green WR (1983) Ocular and Orbital Involvement in Leukemia. Surv Ophthalmol 27:211–232PubMedCrossRef
4.
Padillo D, Mencía E, Gutiérrez E, Martínez MA (1999) Orbital granulocytic sarcoma in a myelodysplastic syndrome. Orbit 18:287–290PubMedCrossRef
5.
Stockl FA, Dolmetsch AM, Saornil MA, Font RL, Burnier MN (1997) Orbital granulocytic sarcoma. Br J Ophthalmol 81:1084–1088PubMedCrossRef
6.
Watkins LM, Remulla HD, Rubin PAD (1997) Orbital granulocytic sarcoma in an elderly patient. Am J Ophthalmol 123:854–856PubMed
Metadata
Title
Orbital Tumour as Initial Manifestation of Acute Myeloid Leukemia: Granulocytic Sarcoma: Case Report
Authors
Erika Maka
Olga Lukáts
Jeannette Tóth
Sándor Fekete
Publication date
01-06-2008
Publisher
Springer Netherlands
Published in
Pathology & Oncology Research / Issue 2/2008
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-008-9028-x

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