Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Clinical Oral Investigations
Published in: Clinical Oral Investigations 1/2018

01-01-2018 | Review

Oral pregabalin for acute pain relief after cervicofacial surgery: a systematic review

Authors: Sara Liébana-Hermoso, Francisco Javier Manzano-Moreno, Manuel Francisco Vallecillo-Capilla, Maria Victoria Olmedo-Gaya

Published in: Clinical Oral Investigations | Issue 1/2018

Login to get access

Abstract

Objective

The objectives of this systematic review were to unify criteria on the effectiveness of oral pregabalin to treat acute post-operative pain after cervicofacial surgery, to establish the most effective dose regimens, and to determine its effect on rescue medicine consumption and its association with adverse effects.

Materials and methods

PubMed/Medline (National Library of Medicine, Washington, DC), Scopus, Web of Science, and Cochrane databases were searched for studies in any language published between January 2000 and September 2016. The following question was posed, in accordance with PRISMA guidelines: Is oral pregabalin effective and safe for the relief of acute pain after cervicofacial surgery? The critical reading of the literature utilized a list of questions prepared by the CASPe Network, applying the Jadad scale for evaluation of the methodological quality of trials.

Results

Eleven randomized controlled clinical trials were selected. The 11 trials obtained a score ≥ 3, considered as Ib evidence level and high quality. A single oral dose of 75-mg pregabalin before or after cervicofacial surgery alleviates pain and lessens the need for rescue analgesia consumption, while the statistical significance of these effects is higher with a single dose of 150-mg pregabalin, either before or after the surgery.

Conclusion

Oral pregabalin appears to significantly alleviate post-operative pain and reduce rescue analgesia consumption, with no severe adverse effects. However, the ideal dose and most effective administration regimen remain controversial issues that need to be addressed in further high-quality clinical trials.

Clinical relevance

These findings suggest that pregabalin may be useful for acute pain relief after cervicofacial surgery.
Literature
1.
Macintyre PE, Schug SA, Scott DA, Visser EJ, Walker SM (2010) Acute pain management: scientific evidence, 3rd edn. ANZCA & FPM, Melbourne
2.
Apfelbaum JL, Gan TJ, Chen C (2003) Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesth Analg 97:534–540CrossRefPubMed
3.
Rosa-Díaz J, Navarrete-Zuazo V, Díaz-Mendiondo M (2014) Aspectos básicos del dolor postoperatorio y la analgesia multimodal preventive. Rev Mex Anestesiol 37:18–26
4.
López Álvarez S, Agustí Martínez-Arcos S, Bustos Molina F et al (2012) Manejo del dolor agudo postoperatorio en cirugía ambulatoria. In: 2° ed. España, Inspira Network
5.
Kumar N (2007) WHO normative guidelines on pain management. World Health Organization, Geneva
6.
7.
8.
Tro A, Quartey GK, Schmelz M et al (2007) Effects of oral pregabalin and aprepitant on pain and central sensitization in the electrical hyperalgesia model in human. Br J Anaesth 98:246–254CrossRef
9.
Richter RW, Portenoy R, Sharma U et al (2005) Relief of painful diabetic peripheral neuropathy with pregabalin: a randomized, placebo-controlled trial. J Pain 6:253–260CrossRefPubMed
10.
Cherry DA, Jacquot F, Sabatowski R et al (2004) Pregabalin reduces pain and improves sleep and mood disturbances in patients with post-herpetic neuralgia: results of a randomised, placebo-controlled clinical trial. J Pain 109:26–35CrossRef
11.
Rose MA, Kam PCA (2002) Gabapentin : pharmacology and its use in pain management. Anaesthesia 57:451–462CrossRefPubMed
12.
Crofford LJ, Rowbotham MC, Mease PJ et al (2005) Pregabalin for the treatment of fibromyalgia syndrome. Arthritis Rheum 52:1264–1273CrossRefPubMed
13.
Feltner DE, Liu-dumaw M, Schweizer E, Bielski R (2011) Efficacy of pregabalin in generalized social anxiety disorder: results of a double-blind, placebo-controlled, fixed-dose study. Int Clin Psychopharm 26:213–220CrossRef
14.
Zimbroff DL, Bielski RJ, Tobias K, Brock JD (2005) Pregabalin for treatment of generalized anxiety disorder. Arch Gen Psychiatry 62:1022–1030CrossRefPubMed
15.
Paech MJ, Goy R, Chua S et al (2007) A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery. Anesth Analg 105:1449–1453CrossRefPubMed
16.
Chang SH, Lee HW, Kim HK, Kim SH, Kim DK (2009) An evaluation of perioperative pregabalin for prevention and attenuation of postoperative shoulder pain after. Anesth Analg 109:1284–1286CrossRefPubMed
17.
Peng PWH, Li C, Farcas E et al (2010) Use of low-dose pregabalin in patients undergoing laparoscopic cholecystectomy. Br J Anaesth 105:155–161CrossRefPubMed
18.
Mathiesen O, Rasmussen ML, Dierking G et al (2009) Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy. A randomized clinical trial. Acta Anaesthesiol Scand 53:227–235CrossRefPubMed
19.
Cheung CW, Choi WS, Leung YY et al (2012) A double-blind randomized crossover study to evaluate the timing of pregabalin for third molar surgery under local anesthesia. J Oral Maxillofac Surg 70:25–30CrossRefPubMed
20.
Ha K, Carragee E, Cheng I, Kwon S, Kim Y (2011) Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells. J Korean Med Sci 26:404–411CrossRefPubMedPubMedCentral
21.
Stahl SM (2004) Mechanism of action of α 2 δ ligands: voltage sensitive calcium channel (VSCC) modulators. J Clin Psychiatry 65:1033–1034CrossRefPubMed
22.
Shneker BF, McAuley JW (2005) Pregabalin: a new neuromodulator with broad therapeutic indications. Ann Pharmacother 39:2029–2037CrossRefPubMed
23.
Bockbrader HN, Radulovic LL, Posvar EL et al (2010) Clinical pharmacokinetics of pregabalin in healthy volunteers. J Clin Pharmacol 50:941–950CrossRefPubMed
24.
Kavoussi R (2006) Pregabalin: from molecule to medicine. J Euroneuro 16(Suppl 2):S128–S133
25.
Eutamene H, Coelho M, Theodorou V et al (2000) Antinociceptive effect of pregabalin in septic shock-induced rectal hypersensitivity in rats. J Pharmacol Exp Ther 295:162–167PubMed
26.
Gilron I (2007) Gabapentin and pregabalin for chronic neuropathic and early postsurgical pain: current evidence and future directions. Curr Opin Anaesthesiol 20:456–472CrossRefPubMed
27.
Cabello JB (2005) Plantilla para ayudarte a entender un Ensayo Clínico.CASPe. Guías CASPe de Lectura Crítica de la Literatura Médica. Alicante: CASPe. Cuaderno I. p5–8
28.
Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12CrossRefPubMed
29.
30.
Ahiskalioglu A, İnce İ, Aksoy M, et al (2015) Effects of a single-dose of pre-emptive pregabalin on postoperative pain and opioid consumption after double-jaw surgery: a randomized controlled trial. J Oral Maxillofac Surg 74:53.e1–53
31.
Cillo JE, Dattilo DJ (2014) Pre-emptive analgesia with pregabalin and celecoxib decreases postsurgical pain following maxillomandibular advancement surgery: a randomized controlled clinical trial. J Oral Maxillofac Surg 72:1909–1914CrossRefPubMed
32.
33.
Park SS, Kim D-H, Nam I-C, Lee I-H, Hwang J-W (2015) The effectiveness of pregabalin for post-tonsillectomy pain control: a randomized controlled trial. PLoS One 10:e0117161CrossRefPubMedPubMedCentral
34.
Kim SY, Jeong JJ, Chung WY et al (2010) Perioperative administration of pregabalin for pain after robot-assisted endoscopic thyroidectomy: a randomized clinical trial. Surg Endosc Other Interv Tech 24:2776–2781CrossRef
35.
Hill CM, Balkenohl M, Thomas DW et al (2001) Pregabalin in patients with postoperative dental pain. Eur J Pain 5:119–124CrossRefPubMed
36.
Pakravan M, Roshani M, Yazdani S, Faramazi A, Yaseri M (2012) Pregabalin and gabapentin for post-photorefractive keratectomy pain: a randomized controlled trial. Eur J Ophthalmol 22(Suppl 7):106–113CrossRef
37.
Sagit M, Yalcin S, Polat H et al (2013) Efficacy of a single preoperative dose of pregabalin for postoperative pain after septoplasty. J Craniofac Surg 24:373–375CrossRefPubMed
38.
Meek JM, Rosbolt MB, Taylor KR et al (2014) Pregabalin versus placebo in postoperative pain relief of patients’ status post photorefractive keratectomy: a double-masked, randomized, prospective study. J Ocul Pharmacol Ther 30:527–532CrossRefPubMed
39.
Mcquay HJ, Poon KH, Derry S, Moore RA (2008) Acute pain: combination treatments and how we measure their efficacy. Br J Anaesth 101:69–76CrossRefPubMed
40.
Korttila K, Jokela R, Ahonen J, Tallgren M, Haanpa M (2008) Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Br J Anaesth 100:834–840CrossRefPubMed
41.
Agarwal A, Gautam S, Gupta D et al (2008) Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy. Br J Anaesth 101:700–704CrossRefPubMed
42.
Bekawi MS, El Wakeel LM, Al Taher WMA, Mageed WMA (2014) Clinical study evaluating pregabalin efficacy and tolerability for pain management in patients undergoing laparoscopic cholecystectomy. Clin J Pain 30:944–952CrossRefPubMed
43.
Balaban F, Yağar S, Özgök A, Koç M, Güllapoğlu H (2012) A randomized, placebo-controlled study of pregabalin for postoperative pain intensity after laparoscopic cholecystectomy. J Clin Anesth 24:175–178CrossRefPubMed
44.
Yadeau JT, Paroli L, Kahn RL et al (2012) Addition of pregabalin to multimodal analgesic therapy following ankle surgery: a randomized double-blind, placebo-controlled trial. Reg Anesth Pain Med 37:302–307CrossRefPubMed
45.
46.
Buvanendran A, Kroin JS, Della Valle CJ et al (2010) Perioperative oral pregabalin reduces chronic pain after total knee arthroplasty: a prospective, randomized, controlled trial. Anesth Analg 110:199–207CrossRefPubMed
47.
Engelman E, Cateloy F (2011) Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. Acta Anaesthesiol Scand 55:927–943PubMed
48.
Zhang J, Ho K-Y, Wang Y (2011) Efficacy of pregabalin in acute postoperative pain: a meta-analysis. Br J Anaesth 106:454–462CrossRefPubMed
49.
Yu L, Ran B, Li M, Shi Z (2013) Gabapentin and pregabalin in the management of postoperative pain after lumber spinal surgery: a systematic review and meta-analysis. Spine 38:1947–1952CrossRefPubMed
50.
Mishriky BM, Waldron NH, Habib AS (2015) Impact of pregabalin on acute and persistent postoperative pain: a systematic review and meta-analysis. Br J Anaesth 114:10–31CrossRefPubMed
Metadata
Title
Oral pregabalin for acute pain relief after cervicofacial surgery: a systematic review
Authors
Sara Liébana-Hermoso
Francisco Javier Manzano-Moreno
Manuel Francisco Vallecillo-Capilla
Maria Victoria Olmedo-Gaya
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 1/2018
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-017-2272-2

Other articles of this Issue 1/2018

Clinical Oral Investigations 1/2018 Go to the issue

Original Article

The impact of rapid maxillary expansion on maxillary first molar root morphology of cleft subjects

Original Article

Single nucleotide polymorphisms in genes of dopaminergic pathways are associated with bruxism

Review

Oral hygiene and oral health in older people with dementia: a comprehensive review with focus on oral soft tissues

Original Article

Oral health in patients with renal disease: a longitudinal study from predialysis to kidney transplantation

Original Article

aMMP-8 in correlation to caries and periodontal condition in adolescents—results of the epidemiologic LIFE child study

Original Article

Bacterial colonization in the apical part of extracted human teeth following root-end resection and filling: a confocal laser scanning microscopy study