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BMC Oral Health
Published in: BMC Oral Health 1/2024

Open Access 01-12-2024 | Oral Microbiota | Research

The impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: a randomized, double-blind, crossover, placebo-controlled trial

Authors: Min-Kang Lee, I-Hui Chen, I-Ling Hsu, Wan-Hua Tsai, Tzong-Yi Lee, Jhih-Hua Jhong, Bai-Chia Liu, Tsui-Yin Huang, Fang-Kuei Lin, Wen-Wei Chang, Ju-Hui Wu

Published in: BMC Oral Health | Issue 1/2024

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Abstract

Background

This study examines the oral health benefits of heat-killed Lacticaseibacillus paracasei GMNL-143, particularly its potential in oral microbiota alterations and gingivitis improvement.

Methods

We assessed GMNL-143’s in vitro interactions with oral pathogens and its ability to prevent pathogen adherence to gingival cells. A randomized, double-blind, crossover clinical trial was performed on gingivitis patients using GMNL-143 toothpaste or placebo for four weeks, followed by a crossover after a washout.

Results

GMNL-143 showed coaggregation with oral pathogens in vitro, linked to its surface layer protein. In patients, GMNL-143 toothpaste lowered the gingival index and reduced Streptococcus mutans in crevicular fluid. A positive relationship was found between Aggregatibacter actinomycetemcomitans and gingival index changes, and a negative one between Campylobacter and gingival index changes in plaque.

Conclusion

GMNL-143 toothpaste may shift oral bacterial composition towards a healthier state, suggesting its potential in managing mild to moderate gingivitis.

Trial registration

ID NCT04190485 (https://​clinicaltrials.​gov/​); 09/12/2019, retrospective registration.
Appendix
Available only for authorised users
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Metadata
Title
The impact of Lacticaseibacillus paracasei GMNL-143 toothpaste on gingivitis and oral microbiota in adults: a randomized, double-blind, crossover, placebo-controlled trial
Authors
Min-Kang Lee
I-Hui Chen
I-Ling Hsu
Wan-Hua Tsai
Tzong-Yi Lee
Jhih-Hua Jhong
Bai-Chia Liu
Tsui-Yin Huang
Fang-Kuei Lin
Wen-Wei Chang
Ju-Hui Wu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2024
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-024-04251-4

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