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European Archives of Oto-Rhino-Laryngology

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01-07-2016 | Miscellaneous

Oral HPV prevalence in women positive for cervical HPV infection and their sexual partners: a German screening study

Authors: Ralf B. Uken, Oliver Brummer, Carolin von Schubert-Bayer, Thomas Brodegger, Ingo U. Teudt

Published in: European Archives of Oto-Rhino-Laryngology | Issue 7/2016

Abstract

The incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell cancer (OSCC) is on the rise. With the HPV-positive uterine cervix as a reservoir, HPV-positive OSCC is discussed as a sexually transmitted disease. Mechanisms of HPV transmission to the oral cavity are poorly understood. To gain more insight into HPV-transmission routes, cervically HPV-positive women and their sexual partners are screened for oral HPV infection. Women with cervical dysplasia underwent HPV testing of the uterine cervix and tonsillar region via brush test. In addition, sexual partners received oral HPV testing. Tonsillar brush tests of patients admitted for routine surgery served as the control group. The HPV-PCR (Roche Linear Array Kit) was used to differentiate 37 HPV types. All participants completed a risk-factor questionnaire focusing on sexual habits. 101 women were tested HPV-positive at the cervix. Only 3/101 (3 %) were tested HPV-positive in the oropharynx. In 60/101 (60 %) women the sexual partner could be tested for oral HPV infection: testing was positive in 3/60 (5 %). No oral HPV was detected in the control group. The risk-factor questionnaire revealed significant differences between the female study- and control group in terms of age at first sexual intercourse and smoking habits. The limited data suggest that among sexual partners in Germany, HPV transmission to the oropharynx by oral–genital sex or by autoinoculation is a rare and unlikely event with low HPV concordance. Another explanation for the low oral prevalence could be an independent clearance of HPV from the oropharyngeal site compared to cervix uteri or at different time intervals.

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Title: Oral HPV prevalence in women positive for cervical HPV infection and their sexual partners: a German screening study
Authors: Ralf B. Uken
Oliver Brummer
Carolin von Schubert-Bayer
Thomas Brodegger
Ingo U. Teudt
Publication date: 01-07-2016
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Oto-Rhino-Laryngology / Issue 7/2016
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-016-3953-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Oral HPV prevalence in women positive for cervical HPV infection and their sexual partners: a German screening study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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