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International Urogynecology Journal

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01-11-2009 | Original Article

Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women

Authors: Mary J. G. Zamboni, Carlos A. P. Cabral, Francisco J. B. Sampaio, Luiz E. M. Cardoso

Published in: International Urogynecology Journal | Issue 11/2009

Abstract

Introduction and hypothesis

Urinary glycosaminoglycans (uGAG) have protective effects against urinary tract disorders. Here we investigated whether oral hormonal contraceptives (OC) affect uGAG excretion.

Methods

Urine specimens were from young women regularly taking: ethinyl estradiol + drospirenone, n = 9; ethinyl estradiol + cyproterone acetate, n = 9; and ethinyl estradiol + gestodene, n = 7. Controls were from ten women not taking OC. Total uGAG was assayed as hexuronic acid/urinary creatinine. Sulfated uGAG species was determined by electrophoresis.

Results

Unlike controls, total uGAG in the two halves of the menstrual cycle was similar in the OC groups. Whole cycle uGAG was higher in the OC groups (p < 0.01), especially for ethinyl estradiol + cyproterone acetate (p < 0.005). The three OC produced decreases of ~50% in heparan sulfate (p < 0.02) and dermatan sulfate (p < 0.02), and a ~100% increase in chondroitin sulfate (p < 0.004).

Conclusions

uGAG excretion is changed in women taking OC, and this might enhance the protective effects of these molecules against urinary tract disorders.

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Title: Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women
Authors: Mary J. G. Zamboni
Carlos A. P. Cabral
Francisco J. B. Sampaio
Luiz E. M. Cardoso
Publication date: 01-11-2009
Publisher: Springer-Verlag
Published in: International Urogynecology Journal / Issue 11/2009
Print ISSN: 0937-3462
Electronic ISSN: 1433-3023
DOI: https://doi.org/10.1007/s00192-009-0948-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Oral hormonal contraceptives affect the concentration and composition of urinary glycosaminoglycans in young women

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction and hypothesis

Methods

Results

Conclusions

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