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BMC Oral Health
Published in: BMC Oral Health 1/2022

Open Access 01-12-2022 | Research

Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study

Authors: Renate Andreassen, Birgitta Jönsson, Elin Hadler-Olsen

Published in: BMC Oral Health | Issue 1/2022

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Abstract

Background

Both the incidence and survival rate of head and neck cancer (HNC) is increasing, making quality of life of HNC survivors an important issue.

Methods

In this cross-sectional study we compared the oral health related quality of life (OHRQoL) of long-term HNC survivors to that of a general population cohort from the seventh survey of the Tromsø study with the Oral Impact on Daily Performances questionnaire. Comparisons were done with frequency analyses and cross tabulation. We also assessed OHRQoL’s association to sociodemographic and oral health related variables in both cohorts as well as with cancer related variables in the HNC cohort with regression analyses.

Results

The HNC survivors had four times the risk of reporting problems with daily performances compared with the general population cohort. The ability to eat and enjoy food was most frequently affected in both cohorts. Moderate-poor self-rated dental health and general health as well as high frequency of dental visits were significantly associated with poorer OHRQoL. To have a history of oral or pharyngeal cancer was associated with more problems than having a history of laryngeal cancer.

Conclusions

Our study shows that HNC treatment is associated with a strong and lasting impairment of OHRQoL, highlighting the need to find less toxic, yet effective ways to treat the disease, and to provide easy access to expert dental care at all stages of the disease to minimize morbidity. Given the widespread side effects of cancer treatment, a multidisciplinary approach might be required to improve the OHRQoL of HNC survivors.
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Literature
1.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.CrossRef
2.
3.
Heijnen BJ, Speyer R, Kertscher B, Cordier R, Koetsenruijter KW, Swan K, et al. Dysphagia, speech, voice, and trismus following radiotherapy and/or chemotherapy in patients with head and neck carcinoma: review of the literature. Biomed Res Int. 2016;2016:6086894.PubMedPubMedCentralCrossRef
4.
Sroussi HY, Epstein JB, Bensadoun RJ, Saunders DP, Lalla RV, Migliorati CA, et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Med. 2017;6(12):2918–31.PubMedPubMedCentralCrossRef
5.
Caudell JJ, Torres-Roca JF, Gillies RJ, Enderling H, Kim S, Rishi A, et al. The future of personalised radiotherapy for head and neck cancer. Lancet Oncol. 2017;18(5):e266–73.PubMedPubMedCentralCrossRef
6.
Nordgren M, Hammerlid E, Bjordal K, Ahlner-Elmqvist M, Boysen M, Jannert M. Quality of life in oral carcinoma: a 5-year prospective study. Head Neck. 2008;30(4):461–70.PubMedCrossRef
7.
Yan YB, Meng L, Liu ZQ, Xu JB, Liu H, Shen J, et al. Quality of life in long-term oral cancer survivors: an 8-year prospective study in China. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(1):67–75.PubMedCrossRef
8.
Rathod S, Gupta T, Ghosh-Laskar S, Murthy V, Budrukkar A, Agarwal J. Quality-of-life (QOL) outcomes in patients with head and neck squamous cell carcinoma (HNSCC) treated with intensity-modulated radiation therapy (IMRT) compared to three-dimensional conformal radiotherapy (3D-CRT): evidence from a prospective randomized study. Oral Oncol. 2013;49(6):634–42.PubMedCrossRef
9.
Singer S, Araujo C, Arraras JI, Baumann I, Boehm A, Brokstad Herlofson B, et al. Measuring quality of life in patients with head and neck cancer: update of the EORTC QLQ-H&N Module. Phase III Head Neck. 2015;37(9):1358–67.PubMedCrossRef
10.
Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European organization for research and treatment of cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365–76.PubMedCrossRef
11.
Soldera EB, Ortigara GB, Bonzanini LIL, Schulz RE, Danesi CC, Antoniazzi RP, et al. Clinical and sociodemographic factors associated with oral health-related quality of life in survivors of head and neck cancer. Head Neck. 2020;42(5):886–97.PubMedCrossRef
12.
de Melo NB, de Sousa VM, Bernardino IM, de Melo DP, Gomes DQ, Bento PM. Oral health related quality of life and determinant factors in patients with head and neck cancer. Med Oral Patol Oral Cir Bucal. 2019;24(3):e281–9.PubMedPubMedCentralCrossRef
13.
Gondivkar SM, Gadbail AR, Sarode SC, Hedaoo A, Dasgupta S, Sharma B, et al. Oral and general health-related quality of life in oral squamous cell carcinoma patients—comparative analysis of different treatment regims. J Oral Biol Craniofac Res. 2021;11(2):125–31.PubMedPubMedCentralCrossRef
14.
Adulyanon S, Sheiham A. Oral Impacts on daily performances. In: Slade GD, editor. Measuring oral health and quality of life. Chapel Hill, NC: Department of Dental Ecology, School of Dentistry, University of North Carolina; 1997. p. 151–60.
15.
Riva F, Seoane M, Reichenheim ME, Tsakos G, Celeste RK. Adult oral health-related quality of life instruments: A systematic review. Community Dent Oral Epidemiol. 2021.
16.
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806–8.CrossRef
17.
Astrom AN, Haugejorden O, Skaret E, Trovik TA, Klock KS. Oral Impacts on daily performance in Norwegian adults: validity, reliability and prevalence estimates. Eur J Oral Sci. 2005;113(4):289–96.PubMedCrossRef
18.
Gouvea GR, Bulgareli JV, David LL, Ambrosano GMB, Cortellazzi KL, Guerra LM, et al. Variables associated with the oral impact on daily performance of adults in the state of Sao Paulo: a population-based study. PLoS ONE. 2018;13(9):e0203777.PubMedPubMedCentralCrossRef
19.
Mohamed HG, Mustafa K, Ibrahim SO, Astrom AN. Dietary habits, oral impact on daily performance and type 2 diabetes: a matched case-control study from Sudan. Health Qual Life Outcomes. 2017;15(1):111.PubMedPubMedCentralCrossRef
20.
da Cunha IP, Pereira AC, Frias AC, Vieira V, de Castro MM, Batista MJ, et al. Social vulnerability and factors associated with oral impact on daily performance among adolescents. Health Qual Life Outcomes. 2017;15(1):173.PubMedPubMedCentralCrossRef
21.
WHO Classification of Head and Neck Tumours. 4th ed. International Agency for Research on Cancer.
22.
Barrios R, Bravo M, Gil-Montoya JA, Martinez-Lara I, Garcia-Medina B, Tsakos G. Oral and general health-related quality of life in patients treated for oral cancer compared to control group. Health Qual Life Outcomes. 2015;13:9.PubMedPubMedCentralCrossRef
23.
Lee NY. Intensity-modulated radiation therapy in the treatment of head and neck cancer involving the base of the skull. Int J Radiat Oncol Biol Phys. 2007;69(2 Suppl):S43–5.PubMedCrossRef
24.
Mortensen HR, Jensen K, Aksglaede K, Behrens M, Grau C. Late dysphagia after IMRT for head and neck cancer and correlation with dose-volume parameters. Radiother Oncol. 2013;107(3):288–94.PubMedCrossRef
25.
Barrios R, Montero J, Gonzalez-Moles MA, Baca P, Bravo M. Levels of scientific evidence of the quality of life in patients treated for oral cancer. Med Oral Patol Oral Cir Bucal. 2013;18(4):e578–84.PubMedPubMedCentralCrossRef
26.
Hadler-Olsen E, Jonsson B. Oral health and use of dental services in different stages of adulthood in Norway: a cross sectional study. BMC Oral Health. 2021;21(1):257.PubMedPubMedCentralCrossRef
27.
Crocombe LA, Broadbent JM, Thomson WM, Brennan DS, Poulton R. Impact of dental visiting trajectory patterns on clinical oral health and oral health-related quality of life. J Public Health Dent. 2012;72(1):36–44.PubMedCrossRef
28.
Donaldson AN, Everitt B, Newton T, Steele J, Sherriff M, Bower E. The effects of social class and dental attendance on oral health. J Dent Res. 2008;87(1):60–4.PubMedCrossRef
29.
30.
Kassebaum NJ, Smith AGC, Bernabe E, Fleming TD, Reynolds AE, Vos T, et al. Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990–2015: a systematic analysis for the global burden of diseases, injuries, and risk factors. J Dent Res. 2017;96(4):380–7.PubMedCrossRef
31.
Gilbert GH, Stoller EP, Duncan RP, Earls JL, Campbell AM. Dental self-care among dentate adults: contrasting problem-oriented dental attenders and regular dental attenders. Spec Care Dentist. 2000;20(4):155–63.PubMedCrossRef
32.
The Norwegian Directorate of Health. Head- and neck cancer—action program. Oslo: The Norwegian Directorate of Health; 2020.
33.
van der Meulen IC, May AM, de Leeuw JR, Koole R, Oosterom M, Hordijk GJ, et al. Long-term effect of a nurse-led psychosocial intervention on health-related quality of life in patients with head and neck cancer: a randomised controlled trial. Br J Cancer. 2014;110(3):593–601.PubMedCrossRef
34.
Rogers SN, Allmark C, Bekiroglu F, Edwards RT, Fabbroni G, Flavel R, et al. Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients: main results of a cluster preference randomised controlled trial. Eur Arch Otorhinolaryngol. 2021;278(9):3435–49.PubMedCrossRef
35.
Ostberg AL, Andersson P, Hakeberg M. Oral impacts on daily performances: associations with self-reported general health and medication. Acta Odontol Scand. 2009;67(6):370–6.PubMedCrossRef
36.
Astrom AN, Ekback G, Ordell S, Unell L. Social inequality in oral health-related quality-of-life, OHRQoL, at early older age: evidence from a prospective cohort study. Acta Odontol Scand. 2011;69(6):334–42.PubMedCrossRef
37.
Koistinen S, Olai L, Stahlnacke K, Falt A, Ehrenberg A. Oral health-related quality of life and associated factors among older people in short-term care. Int J Dent Hyg. 2020;18(2):163–72.PubMedCrossRef
38.
Bansal M, Khatri M, Taneja V. Potential role of periodontal infection in respiratory diseases—a review. J Med Life. 2013;6(3):244–8.PubMedPubMedCentral
39.
Ioannidou E, Swede H, Fares G, Himmelfarb J. Tooth loss strongly associates with malnutrition in chronic kidney disease. J Periodontol. 2014;85(7):899–907.PubMedCrossRef
40.
Nowjack-Raymer RE, Sheiham A. Numbers of natural teeth, diet, and nutritional status in US adults. J Dent Res. 2007;86(12):1171–5.PubMedCrossRef
41.
Ritchie CS, Joshipura K, Silliman RA, Miller B, Douglas CW. Oral health problems and significant weight loss among community-dwelling older adults. J Gerontol A Biol Sci Med Sci. 2000;55(7):M366–71.PubMedCrossRef
42.
Bahat G, Tufan F, Saka B, Akin S, Ozkaya H, Yucel N, et al. Which body mass index (BMI) is better in the elderly for functional status? Arch Gerontol Geriatr. 2012;54(1):78–81.PubMedCrossRef
43.
Ahmad MH, Salleh R, Siew Man C, Pardi M, Che Abdul Rahim N, Shahril N, et al. Malnutrition among the elderly in Malaysia and its associated factors: findings from the National Health and Morbidity Survey 2018. J Nutr Metab. 2021;2021:6639935.PubMedPubMedCentralCrossRef
44.
Barrios R, Tsakos G, Garcia-Medina B, Martinez-Lara I, Bravo M. Oral health-related quality of life and malnutrition in patients treated for oral cancer. Support Care Cancer. 2014;22(11):2927–33.PubMedPubMedCentralCrossRef
45.
Astrom AN, Haugejorden O, Skaret E, Trovik TA, Klock KS. Oral impacts on daily performance in Norwegian adults: the influence of age, number of missing teeth, and socio-demographic factors. Eur J Oral Sci. 2006;114(2):115–21.PubMedCrossRef
46.
Sharpe L, Curran L, Butow P, Thewes B. Fear of cancer recurrence and death anxiety. Psychooncology. 2018;27(11):2559–65.PubMedCrossRef
47.
Kjaer T, Johansen C, Andersen E, Karlsen R, Nielsen AL, Frederiksen K, et al. Do we reach the patients with the most problems? Baseline data from the WebCan study among survivors of head-and-neck cancer, Denmark. J Cancer Surv. 2016;10(2):251–60.CrossRef
Metadata
Title
Oral health related quality of life in long-term survivors of head and neck cancer compared to a general population from the seventh Tromsø study
Authors
Renate Andreassen
Birgitta Jönsson
Elin Hadler-Olsen
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2022
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-022-02140-2

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