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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 1/2007

01-01-2007 | Original Article

Oral Carbohydrate Solution Ameliorates Endotoxemia-Induced Splanchnic Ischemia

Authors: Turgut Deniz, Canan Agalar, Mehmet Ozdogan, Faruk Comu, Mustafa Emirdogan, Seda Taskin, Oral Saygun, Fatih Agalar

Published in: Digestive Diseases and Sciences | Issue 1/2007

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Abstract

The purpose of this study was to investigate the effect of oral administration of a simple carbohydrate solution on splanchnic circulation and bacterial translocation in endotoxemia. Group 1 was sham control; group 2 was starved for 24 hours; in group 3, endotoxin was administrated at the end of starvation; in group 4, carbohydrate solution was administrated via orogastric route for 24 hours; and in group 5, carbohydrate solution was given and endotoxin was administrated at the end of 24 hours. Splanchnic blood flows were recorded and tissue samples were collected for microbiological analyses. There was a significant increase (P<.05) in the incidence of bacterial translocation in starvation. Endotoxemia decreased distal (P=.021) and midmesenteric (P=.046) flow in starved animals. Oral carbohydrate significantly increased ileal blood flow in starvation (P=.036) and endotoxemia (P=.008). In conclusion, oral carbohydrate solution prevents bacterial translocation during starvation and endotoxemia. The possible mechanism is the improvement in the mesenteric blood flow.
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Metadata
Title
Oral Carbohydrate Solution Ameliorates Endotoxemia-Induced Splanchnic Ischemia
Authors
Turgut Deniz
Canan Agalar
Mehmet Ozdogan
Faruk Comu
Mustafa Emirdogan
Seda Taskin
Oral Saygun
Fatih Agalar
Publication date
01-01-2007
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 1/2007
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9441-5

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