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Published in: Oral and Maxillofacial Surgery 4/2014

01-12-2014 | Original Article

Oral capillary hemangioma: A clinical protocol of diagnosis and treatment in adults

Authors: Walessa Brasil da Silva, André Luis Ribeiro Ribeiro, Sílvio Augusto Fernandes de Menezes, João de Jesus Viana Pinheiro, Sérgio de Melo Alves-Junior

Published in: Oral and Maxillofacial Surgery | Issue 4/2014

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Abstract

Purpose

Hemangiomas are benign vascular anomalies characterized by benign proliferation of blood vessels. There are no well-defined criteria for the diagnosis and treatment of oral capillary hemangioma (OCH). The objective of this study is to report a safe, effective, and low-cost protocol for diagnosis and treatment of OCH.

Materials and methods

Eight patients were diagnosed with OCH, through two physical examination maneuvers—the diascopy and head lowering maneuver with abdominal compression (HLMAC). The treatment performed was sclerotherapy with ethanolamine oleate, weekly, until the disappearance of the lesion. No local anesthetics were administered prior to the sclerosing agent injection.

Results

All cases showed a complete remission of the lesions after sclerotherapy. There were no visible scars or compromise esthetics or normal function, and there was no evidence of recurrence. Only one patient had superficial ulceration, which remained asymptomatic and healed without specific treatment.

Conclusions

This protocol was effective in the diagnosis of OCH through two physical examination maneuvers with low-cost and easy implementation, the diascopy and the HLMAC. The low concentration associated with a reduced amount of the sclerosing agent was responsible for the excellent results in the cases treated.
Literature
1.
go back to reference Johann AC, Aguiar MC, do Carmo MA, Gomez RS, Castro WH, Mesquita RA (2005) Sclerotherapy of benign oral vascular lesion with ethanolamine oleate: an open clinical trial with 30 lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:579–84PubMedCrossRef Johann AC, Aguiar MC, do Carmo MA, Gomez RS, Castro WH, Mesquita RA (2005) Sclerotherapy of benign oral vascular lesion with ethanolamine oleate: an open clinical trial with 30 lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:579–84PubMedCrossRef
2.
go back to reference Prado BN, Santos AF, Oliveira JMM, Vaccarezza GF, Freitas CF (2011) Uso de oleato de etanolamina para hemangiomas da cavidade bucal: um estudo de cinco años. Rev Odontol Univ Cid Sao Paulo 23:42–5 [in Portuguese] Prado BN, Santos AF, Oliveira JMM, Vaccarezza GF, Freitas CF (2011) Uso de oleato de etanolamina para hemangiomas da cavidade bucal: um estudo de cinco años. Rev Odontol Univ Cid Sao Paulo 23:42–5 [in Portuguese]
3.
go back to reference Pedron IG, Carnaval TG, Loureiro CCS, Utumi ER, Magalhães JCA, Adde CA (2008) Opção terapêutica de hemangioma labial. Rev Inst Ciênc Saúde 26:477–81 [in Portuguese] Pedron IG, Carnaval TG, Loureiro CCS, Utumi ER, Magalhães JCA, Adde CA (2008) Opção terapêutica de hemangioma labial. Rev Inst Ciênc Saúde 26:477–81 [in Portuguese]
4.
go back to reference Assis GM, Silva RP, Moraes PH, Amaral JIQ, Germano AR (2009) Hemangioma de língua: relato de caso. Rev Cir Traumatol Buco-Maxilo-fac 9(2):59–66 [in Portuguese] Assis GM, Silva RP, Moraes PH, Amaral JIQ, Germano AR (2009) Hemangioma de língua: relato de caso. Rev Cir Traumatol Buco-Maxilo-fac 9(2):59–66 [in Portuguese]
5.
go back to reference Selim H, Selim A, Khachemoune A, Metwally SA (2007) Use of sclerosing agent in the management of oral and perioral hemangiomas: Review and case reports. Med Sci Monit 13(9):CS114–119PubMed Selim H, Selim A, Khachemoune A, Metwally SA (2007) Use of sclerosing agent in the management of oral and perioral hemangiomas: Review and case reports. Med Sci Monit 13(9):CS114–119PubMed
6.
go back to reference Zanettini I, Zanettini RM, Gollo G (2005) Escleroterapia como alternativa de tratamento de lesões vasculares bucais. Clin Pesq Odontol 2(2):119–126 [in Portuguese] Zanettini I, Zanettini RM, Gollo G (2005) Escleroterapia como alternativa de tratamento de lesões vasculares bucais. Clin Pesq Odontol 2(2):119–126 [in Portuguese]
7.
go back to reference Seo J, Utumi E, Zambon C, Pedron I, Rocha A (2009) Escleroterapia de hemangioma labial. Rev Odonto 17(34):106 [in Portuguese] Seo J, Utumi E, Zambon C, Pedron I, Rocha A (2009) Escleroterapia de hemangioma labial. Rev Odonto 17(34):106 [in Portuguese]
8.
go back to reference Wang L, Oliveira DT, Consolaro H, Perez F (1998) Tratamento de hemangioma bucal com agente esclerosante. ROBRAC 7(24):20–2 [in Portuguese] Wang L, Oliveira DT, Consolaro H, Perez F (1998) Tratamento de hemangioma bucal com agente esclerosante. ROBRAC 7(24):20–2 [in Portuguese]
9.
go back to reference Sarmiento ME, Espinosa IV, Quiñones LT, Arias AB (2008) Tratamiento quirúrgico de los hemangiomas faciales en niños. Rev Esp Cir Oral y Maxilofac 30(4):274–280 [in Spanish] Sarmiento ME, Espinosa IV, Quiñones LT, Arias AB (2008) Tratamiento quirúrgico de los hemangiomas faciales en niños. Rev Esp Cir Oral y Maxilofac 30(4):274–280 [in Spanish]
10.
go back to reference Marwah N, Agnihotri A, Dutta S (2006) Central hemangioma: an overview and case report. Pediatr Dent 28(5):460–6 [in Portuguese]PubMed Marwah N, Agnihotri A, Dutta S (2006) Central hemangioma: an overview and case report. Pediatr Dent 28(5):460–6 [in Portuguese]PubMed
11.
go back to reference Hiraki PY, Goldenberg DC (2010) Diagnóstico e tratamento do hemangioma infantil. Rev Bras Cir Plast 25(2):388–97 [in Portuguese] Hiraki PY, Goldenberg DC (2010) Diagnóstico e tratamento do hemangioma infantil. Rev Bras Cir Plast 25(2):388–97 [in Portuguese]
12.
go back to reference Neville BW, Damm DD, Allen CM, Bouquot JE (2009) Oral and maxillofacial pathology, 3rd edn. Elsevier, St. Louis Neville BW, Damm DD, Allen CM, Bouquot JE (2009) Oral and maxillofacial pathology, 3rd edn. Elsevier, St. Louis
13.
go back to reference Eivazi B, Ardelean M, Bäumler W, Berlien HP, Cremer H, Elluru R, Koltai P, Olofsson J, Richter G, Schick B, Werner JA (2009) Update on hemangiomas and vascular malformations of the head and neck. Eur Arch Otorhinolaryngol 266:187–197PubMedCrossRef Eivazi B, Ardelean M, Bäumler W, Berlien HP, Cremer H, Elluru R, Koltai P, Olofsson J, Richter G, Schick B, Werner JA (2009) Update on hemangiomas and vascular malformations of the head and neck. Eur Arch Otorhinolaryngol 266:187–197PubMedCrossRef
14.
go back to reference Pessôa BS (2011) Células endoteliais progenitoras: uma terapia possível? Rev Bras Cardiol 24(2):122–124 [in Portuguese] Pessôa BS (2011) Células endoteliais progenitoras: uma terapia possível? Rev Bras Cardiol 24(2):122–124 [in Portuguese]
15.
go back to reference Das BK, Hoque S (2008) Treatment of venous malformation with ethanolamine oleate. Asian J Surg 31(4):220–4PubMedCrossRef Das BK, Hoque S (2008) Treatment of venous malformation with ethanolamine oleate. Asian J Surg 31(4):220–4PubMedCrossRef
16.
go back to reference Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children: A classification based on endothelial characteristics. Plastic Reconstr Surg 69:412–22CrossRef Mulliken JB, Glowacki J (1982) Hemangiomas and vascular malformations in infants and children: A classification based on endothelial characteristics. Plastic Reconstr Surg 69:412–22CrossRef
17.
go back to reference Uehara S, Osuga K, Yoneda A, Oue T, Yamanaka H, Fukuzawa M (2009) Intralesional sclerotherapy for subcutaneous venous malformations in children. Pediatr Surg Int 25:709–713PubMedCrossRef Uehara S, Osuga K, Yoneda A, Oue T, Yamanaka H, Fukuzawa M (2009) Intralesional sclerotherapy for subcutaneous venous malformations in children. Pediatr Surg Int 25:709–713PubMedCrossRef
18.
go back to reference Egg NSO, Castro CDLS, Rodrigues FN, Cury VF (2009) Melanose racial e outras lesões pigmentadas da cavidade bucal—revisão de literatura. Rev Perio 19(3):49–55 [in Portuguese] Egg NSO, Castro CDLS, Rodrigues FN, Cury VF (2009) Melanose racial e outras lesões pigmentadas da cavidade bucal—revisão de literatura. Rev Perio 19(3):49–55 [in Portuguese]
19.
go back to reference Cardoso CL, Fernandes LMPSR, Rocha JF, Gonçales ES, Ferreira-Júnior O, Taveira LAA (2010) Abordagem cirúrgica de hemangioma intra-oral. Odontol Clin Cient 9(2):177–180 [in Portuguese] Cardoso CL, Fernandes LMPSR, Rocha JF, Gonçales ES, Ferreira-Júnior O, Taveira LAA (2010) Abordagem cirúrgica de hemangioma intra-oral. Odontol Clin Cient 9(2):177–180 [in Portuguese]
20.
go back to reference Gontijo B, Silva CMR, Pereira LB (2003) Hemangioma da infância. An Bras Dermatol 78(6):651–673 [in Portuguese]CrossRef Gontijo B, Silva CMR, Pereira LB (2003) Hemangioma da infância. An Bras Dermatol 78(6):651–673 [in Portuguese]CrossRef
21.
go back to reference Hilz MJ, Ehmann EC, Pauli E, Baltadzhieva R, Koehn J, Moeller S, Defina P, Axelrod FB (2012) Combined counter-maneuvers accelerate recovery from orthostatic hypotension in familial dysautonomia. Acta Neurol Scand 126(3):162–70PubMedCrossRef Hilz MJ, Ehmann EC, Pauli E, Baltadzhieva R, Koehn J, Moeller S, Defina P, Axelrod FB (2012) Combined counter-maneuvers accelerate recovery from orthostatic hypotension in familial dysautonomia. Acta Neurol Scand 126(3):162–70PubMedCrossRef
22.
go back to reference DuBrul EL (1988) Sicher and DuBrul's oral anatomy, 8th edn. Ishiyaku EuroAmerica, St Louis DuBrul EL (1988) Sicher and DuBrul's oral anatomy, 8th edn. Ishiyaku EuroAmerica, St Louis
24.
go back to reference Castro AL, Castro EVFL, Crivelini MM, Simonato LE (2007) Hemangioma capilar em língua: relato de caso. Rev Odonto Cien 22(56):186–189 [in Portuguese] Castro AL, Castro EVFL, Crivelini MM, Simonato LE (2007) Hemangioma capilar em língua: relato de caso. Rev Odonto Cien 22(56):186–189 [in Portuguese]
25.
go back to reference Lloret P (2004) Tratamiento médico de los hemangiomas. An Sist Sanit Navar 27(Suppl 1):81–92 [in Spanish]PubMed Lloret P (2004) Tratamiento médico de los hemangiomas. An Sist Sanit Navar 27(Suppl 1):81–92 [in Spanish]PubMed
26.
go back to reference Pagnocelli RM, Sant'Ana Filho M (1994) Tratamento do hemangioma capilar. Rev Fac Odontol Porto Alegre 35(1):2–5 [in Portuguese] Pagnocelli RM, Sant'Ana Filho M (1994) Tratamento do hemangioma capilar. Rev Fac Odontol Porto Alegre 35(1):2–5 [in Portuguese]
27.
go back to reference Kim JY, Kim DI, Do YS, Lee BB, Kim YW, Shin SW, Byun HS, Roh HG, Choo IW, Hyon WS, Shim JS, Choi JY (2006) Surgical treatment for congenital arteriovenous malformation: 10 years' experience. Eur J Vasc Endovasc Surg 32:101–106PubMedCrossRef Kim JY, Kim DI, Do YS, Lee BB, Kim YW, Shin SW, Byun HS, Roh HG, Choo IW, Hyon WS, Shim JS, Choi JY (2006) Surgical treatment for congenital arteriovenous malformation: 10 years' experience. Eur J Vasc Endovasc Surg 32:101–106PubMedCrossRef
28.
go back to reference Nishikawa M, Sakamoto K, Hidaka M, Yamashita A, Yamamoto G (2006) Venous malformation of the tongue in a child treated by sclerotherapy with ethanolamine oleate: A case report. J Pediatr Surg 41(3):599–600PubMedCrossRef Nishikawa M, Sakamoto K, Hidaka M, Yamashita A, Yamamoto G (2006) Venous malformation of the tongue in a child treated by sclerotherapy with ethanolamine oleate: A case report. J Pediatr Surg 41(3):599–600PubMedCrossRef
29.
go back to reference Hyodoh H, Akiba H, Hyodoh K, Ezoe K, Yotsuyanagi T, Hareyama M (2009) Effects of blood flow control on clinical outcomes after ethanolamine oleate sclerotherapy for vascular malformations. Jpn J Radiol 27(8):297–302PubMedCrossRef Hyodoh H, Akiba H, Hyodoh K, Ezoe K, Yotsuyanagi T, Hareyama M (2009) Effects of blood flow control on clinical outcomes after ethanolamine oleate sclerotherapy for vascular malformations. Jpn J Radiol 27(8):297–302PubMedCrossRef
30.
go back to reference Frieden IJ, Eichenfield LF, Esterly NB, Geronemus R, Mallory SB (1997) Guidelines of care for hemangiomas of infancy. J Am Acad Dermatol 37(4):631–7PubMedCrossRef Frieden IJ, Eichenfield LF, Esterly NB, Geronemus R, Mallory SB (1997) Guidelines of care for hemangiomas of infancy. J Am Acad Dermatol 37(4):631–7PubMedCrossRef
31.
go back to reference Barak S, Katz J, Kaplan I (1991) The CO2 laser in surgery of vascular tumors of the oral cavity in children. ASDC J Dent Child 58(4):293–6PubMed Barak S, Katz J, Kaplan I (1991) The CO2 laser in surgery of vascular tumors of the oral cavity in children. ASDC J Dent Child 58(4):293–6PubMed
32.
go back to reference Volpe A, Boraks S, Genovese WJ (1999) Utilização do Nd:YAP laser como tratamento alternativo de hemangiomas na boca: relato de dois casos clínicos. Rev Odontol Univ Cid Sao Paulo 11(1):45–50 [in Portuguese] Volpe A, Boraks S, Genovese WJ (1999) Utilização do Nd:YAP laser como tratamento alternativo de hemangiomas na boca: relato de dois casos clínicos. Rev Odontol Univ Cid Sao Paulo 11(1):45–50 [in Portuguese]
33.
go back to reference Van Doorne L, Maeseneer MD, Stricker C, Vanrensbergen R, Stricker M (2002) Diagnosis and treatment of vascular lesions of the lip. Br J Oral Maxillofac Surg 40:497–503PubMedCrossRef Van Doorne L, Maeseneer MD, Stricker C, Vanrensbergen R, Stricker M (2002) Diagnosis and treatment of vascular lesions of the lip. Br J Oral Maxillofac Surg 40:497–503PubMedCrossRef
35.
go back to reference Hong SK, Lee HJ, Seo JK, Lee D, Hwang SW, Sung HS (2010) Reactive vascular lesions treated using ethanolamine oleate sclerotherapy. Dermatol Surg 36:1148–1152PubMedCrossRef Hong SK, Lee HJ, Seo JK, Lee D, Hwang SW, Sung HS (2010) Reactive vascular lesions treated using ethanolamine oleate sclerotherapy. Dermatol Surg 36:1148–1152PubMedCrossRef
36.
go back to reference Carramaschi F, Ferreira MC, Goldenberg DC, Camargo CP, Faria JCM, Freitas JM (1991) Tratamento dos angiomas do lábio. Rev Hosp Clin Fac Med Sao Paulo 46(3):128–32 [in Portuguese]PubMed Carramaschi F, Ferreira MC, Goldenberg DC, Camargo CP, Faria JCM, Freitas JM (1991) Tratamento dos angiomas do lábio. Rev Hosp Clin Fac Med Sao Paulo 46(3):128–32 [in Portuguese]PubMed
37.
go back to reference Loureiro CC, Falchet PC, Gavranich J Jr, Lobo Leandro LF (2010) Embolization as the treatment for a life-threatening mandibular arteriovenous malformation. J Craniofac Surg 21(2):380–2PubMedCrossRef Loureiro CC, Falchet PC, Gavranich J Jr, Lobo Leandro LF (2010) Embolization as the treatment for a life-threatening mandibular arteriovenous malformation. J Craniofac Surg 21(2):380–2PubMedCrossRef
38.
go back to reference Robertson CS, Womack C, Robson K, Morris DL (1989) A study of the local toxicity of agents used for variceal injection sclerotherapy. HPB Surg 1(2):149–52PubMedCentralPubMedCrossRef Robertson CS, Womack C, Robson K, Morris DL (1989) A study of the local toxicity of agents used for variceal injection sclerotherapy. HPB Surg 1(2):149–52PubMedCentralPubMedCrossRef
39.
40.
go back to reference Meyer NE (1938) Monoethanolamine oleate—a new chemical for the obliteration of varicose veins. Am J Surg 40:628–9CrossRef Meyer NE (1938) Monoethanolamine oleate—a new chemical for the obliteration of varicose veins. Am J Surg 40:628–9CrossRef
41.
go back to reference Chin DC (1983) Treatment of maxillary hemangioma with a slerosing agent. Oral Surg Oral Med Oral Pathol 55(3):247–9PubMedCrossRef Chin DC (1983) Treatment of maxillary hemangioma with a slerosing agent. Oral Surg Oral Med Oral Pathol 55(3):247–9PubMedCrossRef
42.
go back to reference Baurmash H, Mandel L (1963) The nonsurgical treatment of hemangioma with Sotradecol. Oral Surg Oral Med Oral Pathol 16:777–82PubMedCrossRef Baurmash H, Mandel L (1963) The nonsurgical treatment of hemangioma with Sotradecol. Oral Surg Oral Med Oral Pathol 16:777–82PubMedCrossRef
43.
go back to reference Nishida R, Inoue R, Takimoto Y, Kita T (1999) A sclerosant with astringent properties developed in China for oesophageal varices: comparison with ethanolamine oleate and polidocanol. J Gastroenterol Hepatol 14:481–8PubMedCrossRef Nishida R, Inoue R, Takimoto Y, Kita T (1999) A sclerosant with astringent properties developed in China for oesophageal varices: comparison with ethanolamine oleate and polidocanol. J Gastroenterol Hepatol 14:481–8PubMedCrossRef
44.
go back to reference Hoque S, Das BK (2011) Treatment of venous malformations with ethanolamine oleate: A descriptive study of 83 cases. Pediatr Surg Int 27:527–531PubMedCrossRef Hoque S, Das BK (2011) Treatment of venous malformations with ethanolamine oleate: A descriptive study of 83 cases. Pediatr Surg Int 27:527–531PubMedCrossRef
45.
go back to reference Gelbert F, Enjolras O, Deffrenne D, Aynard A, Mounayer C, Merland JJ (2000) Percutaneous sclerotherapy for venous malformation of the lips: A retrospective study of 23 patients. Neuroradiology 42:692–6PubMedCrossRef Gelbert F, Enjolras O, Deffrenne D, Aynard A, Mounayer C, Merland JJ (2000) Percutaneous sclerotherapy for venous malformation of the lips: A retrospective study of 23 patients. Neuroradiology 42:692–6PubMedCrossRef
46.
go back to reference Bordas JM, Feu F, Vilella A, Rodés J (1989) Anaphylactic reaction to ethanolamine oleate injection in sclerotherapy of esophageal varices. Endoscopy 21(1):50PubMedCrossRef Bordas JM, Feu F, Vilella A, Rodés J (1989) Anaphylactic reaction to ethanolamine oleate injection in sclerotherapy of esophageal varices. Endoscopy 21(1):50PubMedCrossRef
47.
go back to reference Kiripolsky MG (2010) More on ethanolamine oleate as a vascular sclerosant. Dermatol Surg 36:1153–1154PubMedCrossRef Kiripolsky MG (2010) More on ethanolamine oleate as a vascular sclerosant. Dermatol Surg 36:1153–1154PubMedCrossRef
48.
go back to reference Hughes RW Jr, Larson DE, Viggiano TR, Adson MA, van Heerden JA, Reeves CB (1982) Endoscopic variceal sclerosis: A one-year experience. Gastrointest Endosc 28(2):62–6PubMedCrossRef Hughes RW Jr, Larson DE, Viggiano TR, Adson MA, van Heerden JA, Reeves CB (1982) Endoscopic variceal sclerosis: A one-year experience. Gastrointest Endosc 28(2):62–6PubMedCrossRef
Metadata
Title
Oral capillary hemangioma: A clinical protocol of diagnosis and treatment in adults
Authors
Walessa Brasil da Silva
André Luis Ribeiro Ribeiro
Sílvio Augusto Fernandes de Menezes
João de Jesus Viana Pinheiro
Sérgio de Melo Alves-Junior
Publication date
01-12-2014
Publisher
Springer Berlin Heidelberg
Published in
Oral and Maxillofacial Surgery / Issue 4/2014
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI
https://doi.org/10.1007/s10006-013-0436-z

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