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Head and Neck Pathology
Published in: Head and Neck Pathology 4/2020

01-12-2020 | Oral Cancer | Review

Pericyte in Oral Squamous Cell Carcinoma: A Systematic Review

Authors: Isabella Bittencourt Valle, Lauren Frenzel Schuch, Janine Mayra da Silva, Alfonso Gala-García, Ivana Márcia Alves Diniz, Alexander Birbrair, Lucas Guimarães Abreu, Tarcília Aparecida Silva

Published in: Head and Neck Pathology | Issue 4/2020

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Abstract

The microenvironment of oral cancer is highly dynamic and has been proved to affect tumor progression. Pericytes are blood vessels surrounding cells that have recently gained attention for their roles in vascular and cancer biology. The objective of the present study was to survey the scientific literature for conclusive evidence about whether pericytes are part of blood vessels in oral squamous cell carcinoma (OSCC) and their roles in the tumor microenvironment and clinical outcomes. A systematic electronic search was undertaken in Medline Ovid, PubMed, Web of Science, and Scopus. Eligibility criteria were: publications adopting in vivo models of OSCC that included pericyte detection and assessment by pericyte markers (e.g., α-smooth muscle actin, neuron-glial antigen 2 and platelet-derived growth factor receptor-β). The search yielded seven eligible studies (from 2008 to 2018). The markers most commonly used for pericyte detection were α-smooth muscle actin and neuron-glial antigen 2. The studies reviewed showed the presence of immature vessels exhibiting a reduction of pericyte coverage in OSCC and indicated that anti-cancer therapies could contribute to vessel normalization and pericyte regain. The pericyte population is significantly affected during OSCC development and cancer therapy. While these findings might suggest a role for pericytes in OSCC progression, the limited data available do not allow us to conclude whether they modify the tumor microenvironment and clinical outcome.
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Metadata
Title
Pericyte in Oral Squamous Cell Carcinoma: A Systematic Review
Authors
Isabella Bittencourt Valle
Lauren Frenzel Schuch
Janine Mayra da Silva
Alfonso Gala-García
Ivana Márcia Alves Diniz
Alexander Birbrair
Lucas Guimarães Abreu
Tarcília Aparecida Silva
Publication date
01-12-2020
Publisher
Springer US
Published in
Head and Neck Pathology / Issue 4/2020
Electronic ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-020-01188-2

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