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Clinical Oral Investigations

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14-06-2023 | Oral Cancer | Research

Relationship between histopathological therapeutic effect and prognosis in oral cancer patients after preoperative S-1 chemotherapy followed by surgery

Authors: Mai Seki, Takaaki Sano, Masaru Ogawa, Yu Takayama, Satoshi Yokoo, Tetsunari Oyama

Published in: Clinical Oral Investigations | Issue 8/2023

Abstract

Objectives

Preoperative S-1 chemotherapy is administered to prevent tumor proliferation before surgery in oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the relationship between the histological therapeutic effect and prognosis in patients with OSCC after pre-operative S-1 chemotherapy.

Materials and methods

Among 461 OSCC cases, 281 patients who received preoperative S-1 chemotherapy were compared with 180 patients that did not receive chemotherapy to determine the histological therapeutic effect in the resected specimens and the differences in relapse-free survival.

Results

The histological chemotherapeutic effect was well correlated with the subsequent prognosis. In an examination of the combined effect of treatment and ypStage, the groups with good S-1 treatment effects had extremely good prognoses, even if the postoperative resection specimens were within the same ypStage. In a stratified search of patients who received S-1 for more than 7 days and who had a significantly better prognosis than those who did not receive S-1, it was found that the prognosis was significantly better for patients with tongue cancer according to site; furthermore, tongue cancer, age under 70 years of age, male sex, and clinical stage I were factors associated with a significantly better prognosis.

Conclusions

Even if the postoperative resection specimens were within the same ypStage, the groups that responded to S-1 treatment were considered to have extremely good prognoses.

Clinical relevance

A good adaptation for S-1 was tongue cancer, and especially tongue cancer with cStage I, male sex, and age less than 70 years old.

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Shirasaka T, Shimamoto Y, Ohshima H et al (1996) Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs 7:548–557CrossRefPubMed

Schoffski P (2004) The modulated oral fluropyrimidine prodrug S-1, and its use in gastrointestinal cancer and other solid tumors. Anticancer Drugs 15:85–106CrossRefPubMed

Seki-Soda M, Sano T, Ogawa M, Yokoo S, Oyama T (2021) CD15+ tumor infiltrating granulocytic cells can predict recurrence and their depletion is accompanied by good responses to S-1 with oral cancer. Head Neck 43:2457–2467CrossRefPubMed

Tsukuda M, Kida A, Fujii M et al (2005) Randomized scheduling feasibility study of S-1 for adjuvant chemotherapy in advanced head and neck cancer. Br J Cancer 93:884–889CrossRefPubMedCentral

Satoh T, Sakata Y (2012) S-1 for the treatment of gastrointestinal cancer. Expert Opin Pharmacother 13:1943–1959CrossRefPubMed

Imano N, Murakami Y, Kubo K, Kawahara D, Takeuchi Y, Nishibuchi I, Kimura T, Kochi M, Takakura Y, Shimizu W, Egi H, Uegami S, Ohge H, Takahashi S, Ohdan H, Nagata Y (2021) Efficacy and tolerability of preoperative chemoradiotherapy with S-1 alone for locally advanced rectal cancer. J Radiat Res 62:300–308CrossRefPubMed

Sawasaki M, Tsubamoto H, Nakamoto Y, Kakuno A, Sonoda T (2020) S-1, oxaliplatin, Nab-paclitaxel and itraconazole for conversion surgery for advanced or recurrent gastric cancer. Anticancer Res 40:991–997CrossRefPubMed

Kosaka T, Akiyama H, Miyamoto H, Sato S, Tanaka Y, Sato K, Kunisaki C, Endo I (2019) Outcomes of preoperative S-1 and docetaxel combination chemotherapy in patients with locally advanced gastric cancer. Cancer Chemother Pharmacol 83:1047–1055CrossRefPubMed

Nakamoto Y, Noda M, Mikami R, Tokunaga Y, Okumoto T, Kawamura T, Fujiwara H, Doi S, Tomita N (2020) Phase II study of S-1-based sequential combination chemotherapy including oxaliplatin plus bevacizumab and irinotecan with or without cetuximab for metastatic colorectal cancer: the SOBIC trial. Int J Clin Oncol 25:1285–1290CrossRefPubMed

10.

Gao SG, Jia RN, Feng XS, Xie XH, Shan TY, Pan LX, Song NS, Wang YF, Ding KL, Wang LD (2011) Therapeutic effects of combined oxaliplatin and S-1 in older patients with advanced gastric cardiac adenocarcinoma. World J Gastroenterol 17:5221–5226CrossRefPubMedPubMedCentral

11.

Nomura T, Murakami R, Toya R et al (2010) Phase II study of preoperative concurrent chemoradiation therapy with S-1 in patients with T4 oral squamous cell carcinoma. Int J Radiat Oncol Biol Phys 76:1347–1352CrossRefPubMed

12.

Harada H, Omura K, Tomioka H et al (2013) Multicenter phase II trial of preoperative chemoradiotherapy with S-1 for locally advanced oral squamous cell carcinoma. Cancer Chemother Pharmacol 71:1059–1064CrossRefPubMedPubMedCentral

13.

Marta GN, Riera R, Bossi P, Zhong LP, Licitra L, Macedo CR, de Castro JG, Carvalho AL, William WN Jr, Kowalski LP (2015) Induction chemotherapy prior to surgery with or without postoperative radiotherapy for oral cavity cancer patients: systematic review and meta-analysis. Eur J Cancer 51:2596–2603CrossRefPubMed

14.

Matsumiya Y, Imai T, Takeshita A, Meshii N, Katou I, Iwai S, Suematsu M, Omae M, Kanesaki T, Ota Y, Onishi T, Amino K, Sumi T, Niki A, Ueda M, Nakazawa M (2019) Clinicopathological evaluation of preoperative chemotherapy containing S-1 as a treatment for patients with oral squamous cell carcinoma during waiting time for surgery. Gan To Kagaku Ryoho 46:1027–1031PubMed

15.

Namikawa T, Ishida N, Tsuda S, Fujisawa K, Munekage E, Iwabu J, Munekage M, Uemura S, Tsujii S, Maeda H, Kitagawa H, Kobayashi M, Hanazaki KI (2018) Pathological complete response by S-1 chemotherapy in advanced gastric cancer. In Vivo 32:1211–1216CrossRefPubMedPubMedCentral

16.

Ueno H, Ioka T, Ikeda M, Ohkawa S, Yanagimoto H, Boku N, Fukutomi A, Sugimori K, Baba H, Yamao K, Shimamura T, Sho M, Kitano M, Cheng AL, Mizumoto K, Chen JS, Furuse J, Funakoshi A, Hatori T, Yamaguchi T, Egawa S, Sato A, Ohashi Y, Okusaka T, Tanaka M (2013) Randomized phase III study of gemcitabine plus S-1, S-1 alone, or gemcitabine alone in patients with locally advanced and metastatic pancreatic cancer in Japan and Taiwan: GEST study. J Clin Oncol 31:1640–1648CrossRefPubMed

17.

Seki M, Sano T, Ogawa M, Yokoo S, Oyama T (2019) Histopathological changes in tumor budding between biopsy and resected specimens from patients treated with preoperative S-1 chemotherapy for oral cancer. J Oral Pathol Med 48:880–887CrossRef

18.

Buzdar AU (2007) Preoperative chemotherapy treatment of breast cancer–a review. Cancer 110:2394–2407CrossRef

19.

Vega EA, Kutlu OC, Salehi O, James D, Alarcon SV, Herrick B, Krishnan S, Kozyreva O, Conrad C (2020) Preoperative chemotherapy for pancreatic cancer improves survival and R0 rate even in early stage I. J Gastrointest Surg 24:2409–2415CrossRefPubMed

20.

Arredondo J, Pastor E, Simó V, Beltrán M, Castañón C, Magdaleno MC, Matanza I, Notarnicola M, Ielpo B (2020) Neoadjuvant chemotherapy in locally advanced colon cancer: a systematic review. Tech Coloproctol 24:1001–1015CrossRefPubMed

21.

Hanna GG, Siva S, Plumridge N, Solomon B, Ball DL (2014) Preoperative chemotherapy for non-small-cell lung cancer. Lancet 384:232–233CrossRef

22.

Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, Scarffe JH, Lofts FJ, Falk SJ, Iveson TJ, Smith DB, Langley RE, Verma M, Weeden S, Chua YJ (2006) Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. MAGIC trial participants. N Engl J Med 355:11–20CrossRefPubMed

23.

Izumo T, Kirita T, Ariji E, Ozeki S, Okada N, Okabe S et al (2012) General rules for clinical and pathological studies on oral cancer: a synopsis. Jpn J Clin Oncol 42:1099–1109CrossRefPubMed

24.

Tsukahara K, Kubota A, Hasegawa Y, Takemura H, Terada T, Taguchi T et al (2015) Randomized phase III trial of adjuvant chemotherapy with S-1 after curative treatment in patients with squamous-cell carcinoma of the head and neck (ACTS-HNC). PLoS One 10:e0116965CrossRefPubMedPubMedCentral

25.

Hirakawa H, Hanai N, Suzuki H, Nishikawa D, Matayoshi S, Hasegawa Y, Suzuki M (2017) Prognostic importance of pathological response to neoadjuvant chemotherapy followed by definitive surgery in advanced oral squamous cell carcinoma. Jpn J Clin Oncol 47:1038–1046CrossRefPubMed

26.

Kanterman J, Sade-Feldman M, Biton M, Ish-Shalom E, Lasry A, Goldshtein A, Hubert A, Baniyash M (2014) Adverse immunoregulatory effects of 5FU and CPT11 chemotherapy on myeloid-derived suppressor cells and colorectal cancer outcomes. Cancer Res 74:6022–6035CrossRefPubMed

27.

Matsuda Y, Ohkubo S, Nakano-Narusawa Y, Fukumura Y, Hirabayashi K, Yamaguchi H, Sahara Y, Kawanishi A, Takahashi S, Arai T, Kojima M, Mino-Kenudson M (2020) Objective assessment of tumor regression in post-neoadjuvant therapy resections for pancreatic ductal adenocarcinoma: comparison of multiple tumor regression grading systems. Sci Rep 10:18278CrossRefPubMedPubMedCentral

28.

Tanaka Y (2008) The state and ploblems of judging histopathological effect. J Jpn Soc Oral Tumor 20:255–261CrossRef

29.

Choi N, Noh Y, Lee EK, Chung M, Baek CH, Baek KH, Jeong HS (2017) Discrepancy between cTNM and pTNM staging of oral cavity cancers and its prognostic significance. J Surg Oncol 115:1011–1018CrossRef

30.

Almahmoudi R, Kasanen M, Sieviläinen M, Salem A, Pirinen M, Salo T, Al-Samadi A (2019) Prognostic value of blood and lymphatic vessel markers in tongue cancer: a systematic review. Cancer Sci 110:3424–3433CrossRefPubMedPubMedCentral

Title: Relationship between histopathological therapeutic effect and prognosis in oral cancer patients after preoperative S-1 chemotherapy followed by surgery
Authors: Mai Seki
Takaaki Sano
Masaru Ogawa
Yu Takayama
Satoshi Yokoo
Tetsunari Oyama
Publication date: 14-06-2023
Publisher: Springer Berlin Heidelberg
Keywords: Oral Cancer
Cytostatic Therapy
Oral Cavity Carcinoma
Published in: Clinical Oral Investigations / Issue 8/2023
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05112-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between histopathological therapeutic effect and prognosis in oral cancer patients after preoperative S-1 chemotherapy followed by surgery

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Materials and methods

Results

Conclusions

Clinical relevance

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