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BMC Oral Health
Published in: BMC Oral Health 1/2021

Open Access 01-12-2021 | Oral Antidiabetic Drugs | Research

Type 2 diabetes and its characteristics are associated with poor oral health: findings from 60,590 senior women from the E3N study

Authors: Nasser Laouali, Douae El Fatouhi, Gloria Aguayo, Beverley Balkau, Marie-Christine Boutron-Ruault, Fabrice Bonnet, Guy Fagherazzi

Published in: BMC Oral Health | Issue 1/2021

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Abstract

Background

Type 2 diabetes (T2D) has been identified as a risk factor for poor oral health, however, a limited number of oral health and T2D characteristics have been studied so far. We sought to assess T2D status, age at diagnosis, duration since diagnosis and treatment in relation to a variety of oral diseases.

Methods

Cross-sectional data were analyzed from the E3N (Etude Epidémiologique auprès de femmes de l'Education Nationale) cohort study which enrolled 60,590 women. Participants self-reported oral health status, and T2D cases were identified using diabetes-specific questionnaires and drug reimbursement insurance databases. Multivariable-adjusted ORs and 95% CIs were estimated using logistic regression models.

Results

The mean age (SD) of the women was 70 years (7.2), and 4.7% (n = 2857) had T2D. Compared to women without T2D, women with T2D were more likely to report a poor perceived oral health (OR 1.37 [95% CI 1.18, 1.60]), wearing dental prostheses (1.26 [1.14, 1.39]) and having problems of biting and chewing food (1.19 [1.07, 1.33]). In addition, for women with T2D the age at diagnosis (inversely) and the duration (positively) were associated with the likelihood to report poor oral health.

Conclusions

For women with T2D, duration and age at diagnosis are associated with wearing prostheses, problems of biting and chewing, periodontitis and gingivitis.
Appendix
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Literature
1.
Jin LJ, Lamster IB, Greenspan JS, Pitts NB, Scully C, Warnakulasuriya S. Global burden of oral diseases: emerging concepts, management and interplay with systemic health. Oral Dis. 2016;22:609–19.CrossRefPubMed
2.
Watt RG, Daly B, Allison P, Macpherson LMD, Venturelli R, Listl S, et al. Ending the neglect of global oral health: time for radical action. Lancet. 2019;394:261–72.CrossRefPubMed
3.
World Health Organization. The World Health Report 2003: Shaping the future. World Health Organization; 2003.
4.
Patel MH, Kumar JV, Moss ME. Diabetes and tooth loss: an analysis of data from the National Health and Nutrition Examination Survey, 2003–2004. J Am Dent Assoc. 2013;144:478–85.CrossRefPubMed
5.
Albert DA, Ward A, Allweiss P, Graves DT, Knowler WC, Kunzel C, et al. Diabetes and oral disease: implications for health professionals. Ann N Y Acad Sci. 2012;1255:1–15.CrossRefPubMedPubMedCentral
6.
Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer RT, Graziani F, et al. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International Diabetes Federation and the European Federation of Periodontology. J Clin Periodontol. 2018;45:138–49.CrossRefPubMed
7.
8.
9.
Sora ND, Marlow NM, Bandyopadhyay D, Leite RS, Slate EH, Fernandes JK. Metabolic syndrome and periodontitis in Gullah African Americans with type 2 diabetes mellitus. J Clin Periodontol. 2013;40:599–606.CrossRefPubMedPubMedCentral
10.
Taylor JJ, Preshaw PM, Lalla E. A review of the evidence for pathogenic mechanisms that may link periodontitis and diabetes. J Periodontol. 2013;84(4 Suppl):S113–34.PubMed
11.
Casanova L, Hughes FJ, Preshaw PM. Diabetes and periodontal disease: a two-way relationship. Br Dent J. 2014;217:433–7.CrossRefPubMed
12.
Mohamed HG, Idris SB, Ahmed MF, Bøe OE, Mustafa K, Ibrahim SO, et al. Association between oral health status and type 2 diabetes mellitus among Sudanese adults: a matched case-control study. PLoS ONE. 2013;8:e82158.CrossRefPubMedPubMedCentral
13.
Saremi A, Nelson RG, Tulloch-Reid M, Hanson RL, Sievers ML, Taylor GW, et al. Periodontal disease and mortality in type 2 diabetes. Diabetes Care. 2005;28:27–32.CrossRefPubMed
14.
Meenawat A, Punn K, Srivastava V, Meenawat AS, Dolas RS, Govila V. Periodontal disease and type I diabetes mellitus: associations with glycemic control and complications. J Indian Soc Periodontol. 2013;17:597–600.CrossRefPubMedPubMedCentral
15.
Santos VR, Lima JA, Miranda TS, Feres M, Zimmermann GS, Nogueira-Filho GR, et al. Relationship between glycemic subsets and generalized chronic periodontitis in type 2 diabetic Brazilian subjects. Arch Oral Biol. 2012;57:293–9.CrossRefPubMed
16.
Sadeghi R, Taleghani F, Farhadi S. Oral health related quality of life in diabetic patients. J Dent Res Dent Clin Dent Prospects. 2014;8:230–4.PubMedPubMedCentral
17.
Wu C-Z, Yuan Y-H, Liu H-H, Li S-S, Zhang B-W, Chen W, et al. Epidemiologic relationship between periodontitis and type 2 diabetes mellitus. BMC Oral Health. 2020;20:204.CrossRefPubMedPubMedCentral
18.
Earle KA, Ng L, White S, Zitouni K. Sex differences in vascular stiffness and relationship to the risk of renal functional decline in patients with type 2 diabetes. Diab Vasc Dis Res. 2017;14:304–9.CrossRefPubMed
19.
Ramsay SE, Whincup PH, Watt RG, Tsakos G, Papacosta AO, Lennon LT, et al. Burden of poor oral health in older age: findings from a population-based study of older British men. BMJ Open. 2015;5:e009476.CrossRefPubMedPubMedCentral
20.
Clavel-Chapelon F, for the E3N Study Group. Cohort Profile: The French E3N Cohort Study. Int J Epidemiol. 2014;44:801–9.
21.
Laouali N, Mancini FR, Hajji-Louati M, El Fatouhi D, Balkau B, Boutron-Ruault M-C, et al. Dietary inflammatory index and type 2 diabetes risk in a prospective cohort of 70,991 women followed for 20 years: the mediating role of BMI. Diabetologia. 2019;62:2222–32.CrossRefPubMed
22.
23.
Battancs E, Gheorghita D, Nyiraty S, Lengyel C, Eördegh G, Baráth Z, et al. Periodontal disease in diabetes mellitus: a case-control study in smokers and non-smokers. Diabetes Ther. 2020;11:2715–28.CrossRefPubMedPubMedCentral
24.
Gupta N, Gupta ND, Garg S, Goyal L, Gupta A, Khan S, et al. The effect of type 2 diabetes mellitus and smoking on periodontal parameters and salivary matrix metalloproteinase-8 levels. J Oral Sci. 2016;58:1–6.CrossRefPubMed
25.
Levine RS. Obesity, diabetes and periodontitis—a triangular relationship? Br Dent J. 2013;215:35–9.CrossRefPubMed
26.
Fagherazzi G, Gusto G, El Fatouhi D, Mancini FR, Balkau B, Boutron-Ruault M-C, et al. Mentally tiring work and type 2 diabetes in women: a 22-year follow-up study. Eur J Endocrinol. 2019;180:257–63.CrossRefPubMed
27.
Heredia-Ponce E, Irigoyen-Camacho AE, Sánchez-García S. Oral health status of Institutionalized older women from different socioeconomic positions. J Health Care Poor Underserved. 2017;28:1462–76.CrossRefPubMed
28.
29.
Mayard-Pons ML, Rilliard F, Libersa JC, Musset AM, Farge P. Database analysis of a French type 2 diabetic population shows a specific age pattern of tooth extractions and correlates health care utilization. J Diabetes Complicat. 2015;29:993–7.CrossRef
30.
Yoo J-J, Kim D-W, Kim M-Y, Kim Y-T, Yoon J-H. The effect of diabetes on tooth loss caused by periodontal disease: a nationwide population-based cohort study in South Korea. J Periodontol. 2019;90:576–83.CrossRefPubMed
31.
Mealey BL. Diabetes and periodontal disease: two sides of a coin. Compend Contin Educ Dent. 2000;21:943–6, 948, 950, passim; quiz 956.
32.
Singh I, Singh P, Singh A, Singh T, Kour R. Diabetes an inducing factor for dental caries: a case control analysis in Jammu. J Int Soc Prev Community Dent. 2016;6:125–9.CrossRefPubMedPubMedCentral
33.
Latti BR, Kalburge JV, Birajdar SB, Latti RG. Evaluation of relationship between dental caries, diabetes mellitus and oral microbiota in diabetics. J Oral Maxillofac Pathol. 2018;22:282.CrossRefPubMedPubMedCentral
34.
Oates TW, Huynh-Ba G, Vargas A, Alexander P, Feine J. A critical review of diabetes, glycemic control, and dental implant therapy. Clin Oral Implants Res. 2013;24:117–27.CrossRefPubMed
35.
Carneiro VL, Fraiz FC, Ferreira FM, Pintarelli TP, Oliveira ACB, Boguszewski MCS. The influence of glycemic control on the oral health of children and adolescents with diabetes mellitus type 1. Arch Endocrinol Metab. 2015;59:535–40.CrossRefPubMed
36.
Kapp JM, Boren SA, Yun S, LeMaster J. Diabetes and tooth loss in a national sample of dentate adults reporting annual dental visits. Prev Chronic Dis. 2007;4:A59.PubMedPubMedCentral
37.
Moore PA, Weyant RJ, Mongelluzzo MB, Myers DE, Rossie K, Guggenheimer J, et al. Type 1 diabetes mellitus and oral health: assessment of tooth loss and edentulism. J Public Health Dent. 1998;58:135–42.CrossRefPubMed
38.
Moore PA, Weyant RJ, Mongelluzzo MB, Myers DE, Rossie K, Guggenheimer J, et al. Type 1 diabetes mellitus and oral health: assessment of periodontal disease. J Periodontol. 1999;70:409–17.CrossRefPubMed
39.
Isola G, Matarese G, Ramaglia L, Pedullà E, Rapisarda E, Iorio-Siciliano V. Association between periodontitis and glycosylated haemoglobin before diabetes onset: a cross-sectional study. Clin Oral Investig. 2020;24:2799–808.CrossRefPubMed
40.
41.
42.
Ribeiro FV, de Mendonça AC, Santos VR, Bastos MF, Figueiredo LC, Duarte PM. Cytokines and bone-related factors in systemically healthy patients with chronic periodontitis and patients with type 2 diabetes and chronic periodontitis. J Periodontol. 2011;82:1187–96.CrossRefPubMed
43.
Taylor GW. Bidirectional interrelationships between diabetes and periodontal diseases: an epidemiologic perspective. Ann Periodontol. 2001;6:99–112.CrossRefPubMed
44.
Mealey BL. Periodontal disease and diabetes. A two-way street. J Am Dent Assoc. 2006;137(Suppl):26S-31S.CrossRefPubMed
45.
Affret A, Severi G, Dow C, Mancini FR, Rey G, Delpierre C, et al. Socio-economic factors associated with an increase in fruit and vegetable consumption: a 12-year study in women from the E3N-EPIC study. Public Health Nutr. 2018;21:740–55.CrossRefPubMed
Metadata
Title
Type 2 diabetes and its characteristics are associated with poor oral health: findings from 60,590 senior women from the E3N study
Authors
Nasser Laouali
Douae El Fatouhi
Gloria Aguayo
Beverley Balkau
Marie-Christine Boutron-Ruault
Fabrice Bonnet
Guy Fagherazzi
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2021
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-021-01679-w

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