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01-04-2012 | Research Article

Optimization of Coded Aperture Radioscintigraphy for Sentinel Lymph Node Mapping

Authors: Hirofumi Fujii, John D. Idoine, Sylvain Gioux, Roberto Accorsi, David R. Slochower, Richard C. Lanza, John V. Frangioni

Published in: Molecular Imaging and Biology | Issue 2/2012

Abstract

Purpose

Radioscintigraphic imaging during sentinel lymph node (SLN) mapping could potentially improve localization; however, parallel-hole collimators have certain limitations. In this study, we explored the use of coded aperture (CA) collimators.

Procedures

Equations were derived for the six major dependent variables of CA collimators (i.e., masks) as a function of the ten major independent variables, and an optimized mask was fabricated. After validation, dual-modality CA and near-infrared (NIR) fluorescence SLN mapping were performed in pigs.

Results

Mask optimization required the judicious balance of competing dependent variables, resulting in sensitivity of 0.35%, XY resolution of 2.0 mm, and Z resolution of 4.2 mm at an 11.5-cm field of view. The findings in pigs suggested that NIR fluorescence imaging and CA radioscintigraphy could be complementary, but present difficult technical challenges.

Conclusions

This study lays the foundation for using CA collimation for SLN mapping, and also exposes several problems that require further investigation.

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Title: Optimization of Coded Aperture Radioscintigraphy for Sentinel Lymph Node Mapping
Authors: Hirofumi Fujii
John D. Idoine
Sylvain Gioux
Roberto Accorsi
David R. Slochower
Richard C. Lanza
John V. Frangioni
Publication date: 01-04-2012
Publisher: Springer-Verlag
Published in: Molecular Imaging and Biology / Issue 2/2012
Print ISSN: 1536-1632
Electronic ISSN: 1860-2002
DOI: https://doi.org/10.1007/s11307-011-0494-2

At a glance: The STEP trials

Springer Medicine

Optimization of Coded Aperture Radioscintigraphy for Sentinel Lymph Node Mapping

Abstract

Purpose

Procedures

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Procedures

Results

Conclusions

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