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The International Journal of Cardiovascular Imaging

Published in:

01-10-2019 | Original Paper

Optical coherence tomography evaluation of the absorb bioresorbable scaffold performance for overlap versus non-overlap segments in patients with coronary chronic total occlusion: insight from the GHOST-CTO registry

Authors: Gabriel T. R. Pereira, Alessio La Manna, Yasuhiro Ichibori, Armando Vergara-Martel, Bruno Ramos Nascimento, Abdul Jawwad Samdani, Davide Capodanno, Guido D’Agosta, Giacomo Gravina, Giuseppe Venuti, Corrado Tamburino, Guilherme F. Attizzani

Published in: The International Journal of Cardiovascular Imaging | Issue 10/2019

Abstract

The Absorb bioresorbable vascular scaffold (BVS) promised to avoid some of the disadvantages of its metal predecessors. Even though it has been taken off the market, limited data is available about its use in coronary chronic total occlusion (CTO) and its performance in overlap segments, which would be of special research interest due to its large thickness. This data is still pertinent since the platform of bioresorbable devices has not been abandoned, with several companies working on it. We aimed to compare healing and performance between overlap (OL) and non-overlap regions (NOL) of CTO lesions treated with BVS, using optical coherence tomography (OCT). Fourteen patients with overlapping BVS were included from the GHOST-CTO registry, resulting in 25 OL and 38 NOL regions. OCT based parameters were compared between OL and NOL groups at baseline (post-implantation) and 12-month follow-up. The mean age was 61.7 ± 7.2 years and 12 (86%) were males. Twelve (86%) patients underwent PCI for stable coronary artery disease and 2 (14%) had unstable angina. At 12-month follow-up, mean lumen area decreased in both NOL and OL regions, but the decrease was significantly larger in the OL region (NOL − 0.7 ± 1.33 vs. OL − 2.4 ± 1.54 mm²; p = 0.002). Mean scaffold area increased in both regions, but increased significantly more in NOL ( + 1.1 ± 1.54 vs. + 0.4 ± 1.16 mm²; p = 0.016). The percent of uncovered struts was lower in the OL group (5.0 ± 6.6% vs. 3.75 ± 8.7%, p = 0.043), whereas the percentage of malapposed struts was similar (0.3 ± 0.5% vs. 0.7 ± 2.3%, p = 0.441). Neointimal hyperplasia (NIH) was more pronounced in the OL region (0.13 ± 0.04 vs. 0.24 ± 0.10 mm², p = 0.001). The OL and NOL segments showed comparable healing in terms of coverage and malapposition. However, NIH was more prominent in OL region. The long-term clinical implications of these findings needs further evaluation. The present study provides important insights for future development of BVS technology.

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Title: Optical coherence tomography evaluation of the absorb bioresorbable scaffold performance for overlap versus non-overlap segments in patients with coronary chronic total occlusion: insight from the GHOST-CTO registry
Authors: Gabriel T. R. Pereira
Alessio La Manna
Yasuhiro Ichibori
Armando Vergara-Martel
Bruno Ramos Nascimento
Abdul Jawwad Samdani
Davide Capodanno
Guido D’Agosta
Giacomo Gravina
Giuseppe Venuti
Corrado Tamburino
Guilherme F. Attizzani
Publication date: 01-10-2019
Publisher: Springer Netherlands
Published in: The International Journal of Cardiovascular Imaging / Issue 10/2019
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-019-01636-3

2024 ASCO Annual Meeting

Springer Medicine

Optical coherence tomography evaluation of the absorb bioresorbable scaffold performance for overlap versus non-overlap segments in patients with coronary chronic total occlusion: insight from the GHOST-CTO registry

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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