Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Lasers in Medical Science
Published in: Lasers in Medical Science 3/2014

Open Access 01-05-2014 | Review Article

Optical biopsy of epithelial cancers by optical coherence tomography (OCT)

Authors: R. Wessels, D. M. De Bruin, D. J. Faber, T. G. Van Leeuwen, M. Van Beurden, T. J. M. Ruers

Published in: Lasers in Medical Science | Issue 3/2014

Login to get access

Abstract

Optical coherence tomography (OCT) is an optical technique that measures the backscattering of near-infrared light by tissue. OCT yields in 2D and 3D images at micrometer-scale resolution, thus providing optical biopsies, approaching the resolution of histopathological imaging. The technique has shown to allow in vivo differentiation between benign and malignant epithelial tissue, through qualitative assessment of OCT images, as well as by quantitative evaluation, e.g., functional OCT. This study aims to summarize the principles of OCT and to discuss the current literature on the diagnostic value of OCT in the diagnosis of epithelial (pre)malignant lesions. The authors did a systematic search of the electronic databases PubMed and Embase on OCT in the diagnostic process of (pre)malignant epithelial lesions. OCT is able to differentiate between benign and (pre)malignant lesions of epithelial origin in a wide variety of tissues. In this way, OCT can detect skin cancers, oral, laryngeal, and esophageal cancer as well as genital and bladder cancer. OCT is an innovative technique which enables an optical biopsy of epithelial lesions. The incorporation of OCT in specific tools, like handheld and catheter-based probes, will further improve the implementation of this technology in daily clinical practice.
Literature
1.
2.
Izatt JA, Hee MR, Swanson EA, Lin CP, Huang D, Schuman JS, Puliafito CA, Fujimoto JG (1994) Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography. Arch Ophthalmol 112(12):1584–1589PubMedCrossRef
3.
Hee MR, Izatt JA, Swanson EA, Huang D, Schuman JS, Lin CP, Puliafito CA, Fujimoto JG (1995) Optical coherence tomography of the human retina. Arch Ophthalmol 113(3):325–332PubMedCrossRef
4.
Drexler W, Fugimoto J (eds) (2008) Optical coherence tomography: technology and applications, 2008th edn. Springer, New York
5.
van Zeeburg EJ, Cereda MG, van der Schoot J, Pertile G, van Meurs JC (2011) Early perfusion of a free RPE-choroid graft in patients with exudative macular degeneration can be imaged with spectral domain-OCT. Invest Ophthalmol Vis Sci 52(8):5881–5886PubMedCrossRef
6.
Srinivasan VJ, Radhakrishnan H, Lo EH, Mandeville ET, Jiang JY, Barry S, Cable AE (2012) OCT methods for capillary velocimetry. Biomed Opt Express 3(3):612–629PubMedCentralPubMedCrossRef
7.
Barwari K et al (2010) Advanced diagnostics in renal mass using optical coherence tomography: a preliminary report. J Endourol 25(2):311–315, 2011FebCrossRef
8.
Barwari K, de Bruin DM, Faber DJ, van Leeuwen TG, de la Rosette JJ, Laguna MP (2012) Differentiation between normal renal tissue and renal tumours using functional optical coherence tomography: a phase I in vivo human study. BJU Int 110(8PtB):E415–E420, 2012OctPubMedCrossRef
9.
Cauberg ECC et al (2010) Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder. J Biomed Opt 15(6):066013, 2010Nov-DecPubMedCrossRef
10.
Wessels R, de Bruin DM, Faber DJ, van Boven HH, Vincent AD, van Leeuwen TG, van Beurden M, Ruersa TJ (2012) Optical coherence tomography in vulvar intraepithelial neoplasia. J Biomed Opt 17(11):116022PubMedCrossRef
11.
Bista RK, Uttam S, Wang P, Staton K, Choi S, Bakkenist CJ, Hartman DJ, Brand RE, Liu Y (2011) Quantification of nanoscale nuclear refractive index changes during the cell cycle. J Biomed Opt 16(7):070503PubMedCentralPubMedCrossRef
12.
13.
Neville JA, Welch E, Leffell DJ (2007) Management of nonmelanoma skin cancer in 2007. Nat Clin Pract Oncol 4(8):462–469PubMedCrossRef
14.
Gambichler T, Orlikov A, Vasa R, Moussa G, Hoffmann K, Stucker M, Altmeyer P, Bechara FG (2007) In vivo optical coherence tomography of basal cell carcinoma. J Dermatol Sci 45(3):167–173PubMedCrossRef
15.
Jorgensen TM, Tycho A, Mogensen M, Bjerring P, Jemec GB (2008) Machine-learning classification of non-melanoma skin cancers from image features obtained by optical coherence tomography. Skin Res Technol 14(3):364–369PubMedCrossRef
16.
Mogensen M, Joergensen TM, Nurnberg BM, Morsy HA, Thomsen JB, Thrane L, Jemec GB (2009) Assessment of optical coherence tomography imaging in the diagnosis of non-melanoma skin cancer and benign lesions versus normal skin: observer-blinded evaluation by dermatologists and pathologists. Dermatol Surg 35(6):965–972PubMedCrossRef
17.
Mogensen M, Nurnberg BM, Forman JL, Thomsen JB, Thrane L, Jemec GB (2009) In vivo thickness measurement of basal cell carcinoma and actinic keratosis with optical coherence tomography and 20-MHz ultrasound. Br J Dermatol 160(5):1026–1033PubMedCrossRef
18.
Olmedo JM, Warschaw KE, Schmitt JM, Swanson DL (2006) Optical coherence tomography for the characterization of basal cell carcinoma in vivo: a pilot study. J Am Acad Dermatol 55(3):408–412PubMedCrossRef
19.
Olmedo JM, Warschaw KE, Schmitt JM, Swanson DL (2007) Correlation of thickness of basal cell carcinoma by optical coherence tomography in vivo and routine histologic findings: a pilot study. Dermatol Surg 33(4):421–425PubMedCrossRef
20.
Strasswimmer J, Pierce MC, Park BH, Neel V, de Boer JF (2004) Polarization-sensitive optical coherence tomography of invasive basal cell carcinoma. J Biomed Opt 9(2):292–298PubMedCrossRef
21.
de Giorgi SM, Massi D, Mavilia L, Cappugi P, Carli P (2005) Possible histopathologic correlates of dermoscopic features in pigmented melanocytic lesions identified by means of optical coherence tomography. Exp Dermatol 14(1):56–59PubMedCrossRef
22.
Gambichler T, Regeniter P, Bechara FG, Orlikov A, Vasa R, Moussa G, Stucker M, Altmeyer P, Hoffmann K (2007) Characterization of benign and malignant melanocytic skin lesions using optical coherence tomography in vivo. J Am Acad Dermatol 57(4):629–637PubMedCrossRef
23.
Prestin S, Rothschild SI, Betz CS, Kraft M (2012) Measurement of epithelial thickness within the oral cavity using optical coherence tomography. Head Neck 34(12):1777–1781, 2012DecPubMedCrossRef
24.
Wilder-Smith P, Lee K, Guo S, Zhang J, Osann K, Chen Z, Messadi D (2009) In vivo diagnosis of oral dysplasia and malignancy using optical coherence tomography: preliminary studies in 50 patients. Lasers Surg Med 41(5):353–357PubMedCentralPubMedCrossRef
25.
Tsai MT, Lee CK, Lee HC, Chen HM, Chiang CP, Wang YM, Yang CC (2009) Differentiating oral lesions in different carcinogenesis stages with optical coherence tomography. J Biomed Opt 14(4):044028PubMedCrossRef
26.
Adegun OK, Tomlins PH, Hagi-Pavli E, Bader DL, Fortune F (2012) Quantitative optical coherence tomography of fluid-filled oral mucosal lesions. Lasers Med Sci 27(4):795–804, 2012JulPubMedCrossRef
27.
Wong BJ, Jackson RP, Guo S, Ridgway JM, Mahmood U, Su J, Shibuya TY, Crumley RL, Gu M, Armstrong WB, Chen Z (2005) In vivo optical coherence tomography of the human larynx: normative and benign pathology in 82 patients. Laryngoscope 115(11):1904–1911PubMedCrossRef
28.
Lagergren J, Bergstrom R, Lindgren A, Nyren O (1999) Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 340(11):825–831PubMedCrossRef
29.
Cilesiz I, Fockens P, Kerindongo R, Faber D, Tytgat G, Ten Kate F, Van Leeuwen T (2002) Comparative optical coherence tomography imaging of human esophagus: how accurate is localization of the muscularis mucosae? Gastrointest Endosc 56(6):852–857PubMedCrossRef
30.
Cobb MJ, Hwang JH, Upton MP, Chen Y, Oelschlager BK, Wood DE, Kimmey MB, Li X (2010) Imaging of subsquamous Barrett’s epithelium with ultrahigh-resolution optical coherence tomography: a histologic correlation study. Gastrointest Endosc 71(2):223–230PubMedCrossRef
31.
Pitris C, Jesser C, Boppart SA, Stamper D, Brezinski ME, Fujimoto JG (2000) Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies. J Gastroenterol 35(2):87–92PubMedCrossRef
32.
Poneros JM, Brand S, Bouma BE, Tearney GJ, Compton CC, Nishioka NS (2001) Diagnosis of specialized intestinal metaplasia by optical coherence tomography. Gastroenterology 120(1):7–12PubMedCrossRef
33.
Zuccaro G, Gladkova N, Vargo J, Feldchtein F, Zagaynova E, Conwell D, Falk G, Goldblum J, Dumot J, Ponsky J, Gelikonov G, Davros B, Donchenko E, Richter J (2001) Optical coherence tomography of the esophagus and proximal stomach in health and disease. Am J Gastroenterol 96(9):2633–2639PubMedCrossRef
34.
Isenberg G, Sivak MV Jr, Chak A, Wong RC, Willis JE, Wolf B, Rowland DY, Das A, Rollins A (2005) Accuracy of endoscopic optical coherence tomography in the detection of dysplasia in Barrett’s esophagus: a prospective, double-blinded study. Gastrointest Endosc 62(6):825–831PubMedCrossRef
35.
Evans JA, Poneros JM, Bouma BE, Bressner J, Halpern EF, Shishkov M, Lauwers GY, Mino-Kenudson M, Nishioka NS, Tearney GJ (2006) Optical coherence tomography to identify intramucosal carcinoma and high-grade dysplasia in Barrett’s esophagus. Clin Gastroenterol Hepatol 4(1):38–43PubMedCentralPubMedCrossRef
36.
Suter MJ, Vakoc BJ, Yachimski PS, Shishkov M, Lauwers GY, Mino-Kenudson M, Bouma BE, Nishioka NS, Tearney GJ (2008) Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging. Gastrointest Endosc 68(4):745–753PubMedCentralPubMedCrossRef
37.
Vakoc BJ, Shishko M, Yun SH, Oh WY, Suter MJ, Desjardins AE, Evans JA, Nishioka NS, Tearney GJ, Bouma BE (2007) Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video). Gastrointest Endosc 65(6):898–905PubMedCentralPubMedCrossRef
38.
Van Seters M, van Beurden M, de Craen AJ (2005) Is the assumed natural history of vulvar intraepithelial neoplasia III based on enough evidence? A systematic review of 3322 published patients. Gynecol Oncol 97(2):645–651PubMedCrossRef
39.
Andersen BL, Turnquist D, LaPolla J, Turner D (1988) Sexual functioning after treatment of in situ vulvar cancer: preliminary report. Obstet Gynecol 71(1):15–19PubMedCentralPubMed
40.
Judson PL, Habermann EB, Baxter NN, Durham SB, Virnig BA (2006) Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol 107(5):1018–1022PubMedCrossRef
41.
Escobar PF, Belinson JL, White A, Shakhova NM, Feldchtein FI, Kareta MV, Gladkova ND (2004) Diagnostic efficacy of optical coherence tomography in the management of preinvasive and invasive cancer of uterine cervix and vulva. Int J Gynecol Cancer 14(3):470–474PubMedCrossRef
42.
Gallwas JK, Turk L, Stepp H, Mueller S, Ochsenkuehn R, Friese K, Dannecker C (2011) Optical coherence tomography for the diagnosis of cervical intraepithelial neoplasia. Lasers Surg Med 43(3):206–212PubMedCrossRef
43.
Pitris C, Goodman A, Boppart SA, Libus JJ, Fujimoto JG, Brezinski ME (1999) High-resolution imaging of gynecologic neoplasms using optical coherence tomography. Obstet Gynecol 93(1):135–139PubMedCrossRef
44.
Zuluaga AF, Follen M, Boiko I, Malpica A, Richards-Kortum R (2005) Optical coherence tomography: a pilot study of a new imaging technique for noninvasive examination of cervical tissue. Am J Obstet Gynecol 193(1):83–88PubMedCrossRef
45.
Escobar PF, Rojas-Espaillat L, Tisci S, Enerson C, Brainard J, Smith J, Tresser NJ, Feldchtein FI, Rojas LB, Belinson JL (2006) Optical coherence tomography as a diagnostic aid to visual inspection and colposcopy for preinvasive and invasive cancer of the uterine cervix. Int J Gynecol Cancer 16(5):1815–1822PubMedCrossRef
46.
Liu Z, Belinson SE, Li J, Yang B, Wulan N, Tresser NJ, Wang C, Mohr M, Zhang L, Zhou Y, Weng L, Wu R, Belinson JL (2010) Diagnostic efficacy of real-time optical coherence tomography in the management of preinvasive and invasive neoplasia of the uterine cervix. Int J Gynecol Cancer 20(2):283–287PubMedCrossRef
47.
Lee SW, Yoo JY, Kang JH, Kang MS, Jung SH, Chong Y, Cha DS, Han KH, Kim BM (2008) Optical diagnosis of cervical intraepithelial neoplasm (CIN) using polarization-sensitive optical coherence tomography. Opt Express 16(4):2709–2719PubMedCrossRef
48.
Jesser CA, Boppart SA, Pitris C, Stamper DL, Nielsen GP, Brezinski ME, Fujimoto JG (1999) High resolution imaging of transitional cell carcinoma with optical coherence tomography: feasibility for the evaluation of bladder pathology. Br J Radiol 72(864):1170–1176PubMed
49.
Tearney GJ, Brezinski ME, Southern JF, Bouma BE, Boppart SA, Fujimoto JG (1997) Optical biopsy in human urologic tissue using optical coherence tomography. J Urol 157(5):1915–1919PubMedCrossRef
50.
Hermes B, Spoler F, Naami A, Bornemann J, Forst M, Grosse J, Jakse G, Knuchel R (2008) Visualization of the basement membrane zone of the bladder by optical coherence tomography: feasibility of noninvasive evaluation of tumor invasion. Urology 72(3):677–681PubMedCrossRef
51.
Manyak MJ, Gladkova ND, Makari JH, Schwartz AM, Zagaynova EV, Zolfaghari L, Zara JM, Iksanov R, Feldchtein FI (2005) Evaluation of superficial bladder transitional-cell carcinoma by optical coherence tomography. J Endourol 19(5):570–574PubMedCrossRef
52.
Goh AC, Tresser NJ, Shen SS, Lerner SP (2008) Optical coherence tomography as an adjunct to white light cystoscopy for intravesical real-time imaging and staging of bladder cancer. Urology 72(1):133–137PubMedCrossRef
53.
Lingley-Papadopoulos CA, Loew MH, Manyak MJ, Zara JM (2008) Computer recognition of cancer in the urinary bladder using optical coherence tomography and texture analysis. J Biomed Opt 13(2):024003PubMedCrossRef
54.
Faber D, van der Meer F, Aalders M, van Leeuwen T (2004) Quantitative measurement of attenuation coefficients of weakly scattering media using optical coherence tomography. Opt Express 12(19):4353–4365PubMedCrossRef
55.
Faber DJ, van Leeuwen TG (2009) Are quantitative attenuation measurements of blood by optical coherence tomography feasible? Opt Lett 34(9):1435–1437PubMedCrossRef
56.
Patil CA, Kalkman J, Faber DJ, Nyman JS, van Leeuwen TG, Mahadevan-Jansen A (2011) Integrated system for combined Raman spectroscopy-spectral domain optical coherence tomography. J Biomed Opt 16(1):011007PubMedCentralPubMedCrossRef
57.
58.
Bosschaart N, Faber DJ, van Leeuwen TG, Aalders MC (2011) In vivo low-coherence spectroscopic measurements of local hemoglobin absorption spectra in human skin. J Biomed Opt 16(10):100504PubMedCrossRef
Metadata
Title
Optical biopsy of epithelial cancers by optical coherence tomography (OCT)
Authors
R. Wessels
D. M. De Bruin
D. J. Faber
T. G. Van Leeuwen
M. Van Beurden
T. J. M. Ruers
Publication date
01-05-2014
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 3/2014
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-013-1291-8

Other articles of this Issue 3/2014

Lasers in Medical Science 3/2014 Go to the issue

Original Article

Photodynamic antimicrobial chemotherapy (PACT) inhibits biofilm formation by Candida albicans, increasing both ROS production and membrane permeability

Original Article

Effects of Er,Cr:YSGG laser irradiation on the surface characteristics of titanium discs: An in vitro study

Original Article

Light-emitting diode phototherapy improves muscle recovery after a damaging exercise

Original Article

Heat dissipation after nonanatomical lung resection using a laser is mainly due to emission to the environment: an experimental ex vivo study

Original Article

The dawn of computer-assisted robotic osteotomy with ytterbium-doped fiber laser

Original Article

Influence of laser light on bioimplants used in otorhinolaryngology