Skip to main content
Top
Published in: European Journal of Plastic Surgery 2/2023

04-10-2022 | Opioids | Original Paper

Transversus abdominus plane blocks do not reduce rates of postoperative prolonged opioid use following abdominally based autologous breast reconstruction: a nationwide longitudinal analysis

Authors: Arhana Chattopadhyay, Jennifer Krupa Shah, Pooja Yesantharao, Vy Thuy Ho, Clifford C. Sheckter, Rahim Nazerali

Published in: European Journal of Plastic Surgery | Issue 2/2023

Login to get access

Abstract

Background

The transversus abdominus plane (TAP) block reduces postoperative donor site pain in patients undergoing autologous breast reconstruction with an abdominally based flap. This study aimed to determine the effect of TAP blocks on rates of conversion to chronic opioid use.

Methods

The Clinformatics Data Mart was queried from 2003 to 2019, extracting adult encounters for abdominally based free and pedicled flaps based on common procedural terminology (CPT) codes. Patients were excluded if they had filled a narcotic prescription 1 year to 30 days prior to surgery. The exposure variable—TAP block—was identified by CPT codes. Outcomes were evaluated using morphine milligram equivalents (MME) from prescriptions filled between 30 days prior to and 30 days after surgery. Chronic opioid use (COU) was defined as receiving 4 unique prescriptions or a 60-day supply between 30 and 180 days after surgery.

Results

Of the 4091 patients, (mean age 51.2 ± 9.0 years), 181 (4.4%) had a TAP block placed. Perioperative MMEs/day, postoperative COU, and length of stay did not differ in patients who received a TAP block (p = 0.142; p = 0.271). Significant predictors of risk of conversion to COU included younger age, pedicled abdominal flap, Elixhauser comorbidity index score > 3, filling a psychiatric medication prescription, and filling a benzodiazepine prescription.

Conclusions

In patients undergoing autologous breast reconstruction with abdominally based flap reconstruction, TAP blocks do not decrease perioperative MME/day, conversion to chronic opioid use, or length of stay. These data suggest that intraoperative TAP block placement may be a low-yield opioid-reduction strategy.
Level of evidence: Level III, risk/prognostic study
Appendix
Available only for authorised users
Literature
3.
go back to reference Bohnert ASB et al (2011) Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA - J Am Med Assoc 305:1315–1321CrossRef Bohnert ASB et al (2011) Association between opioid prescribing patterns and opioid overdose-related deaths. JAMA - J Am Med Assoc 305:1315–1321CrossRef
5.
go back to reference Strickler GK et al (2019) Effects of mandatory prescription drug monitoring program (PDMP) use laws on prescriber registration and use and on risky prescribing. Drug Alcohol Depend 199:1–9CrossRefPubMed Strickler GK et al (2019) Effects of mandatory prescription drug monitoring program (PDMP) use laws on prescriber registration and use and on risky prescribing. Drug Alcohol Depend 199:1–9CrossRefPubMed
6.
go back to reference Shev AB et al (2018) Prescription drug monitoring program: registration and use by prescribers and pharmacists before and after legal mandatory registration, California, 2010–2017. Am J Public Health 108:1669–1674CrossRefPubMedPubMedCentral Shev AB et al (2018) Prescription drug monitoring program: registration and use by prescribers and pharmacists before and after legal mandatory registration, California, 2010–2017. Am J Public Health 108:1669–1674CrossRefPubMedPubMedCentral
7.
go back to reference Alam A et al (2012) Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med 172:425–430CrossRefPubMed Alam A et al (2012) Long-term analgesic use after low-risk surgery: a retrospective cohort study. Arch Intern Med 172:425–430CrossRefPubMed
8.
go back to reference Hah JM, Bateman BT, Ratliff J, Curtin C, Sun E (2017) Chronic opioid use after surgery: implications for perioperative management in the face of the opioid epidemic. Anesth Analg 125:1733–1740CrossRefPubMedPubMedCentral Hah JM, Bateman BT, Ratliff J, Curtin C, Sun E (2017) Chronic opioid use after surgery: implications for perioperative management in the face of the opioid epidemic. Anesth Analg 125:1733–1740CrossRefPubMedPubMedCentral
10.
go back to reference Chan EY, Fransen M, Parker DA, Assam PN, Chua N (2014) Femoral nerve blocks for acute postoperative pain after knee replacement surgery. Cochrane Database Syst Rev 2014 Chan EY, Fransen M, Parker DA, Assam PN, Chua N (2014) Femoral nerve blocks for acute postoperative pain after knee replacement surgery. Cochrane Database Syst Rev 2014
11.
go back to reference Andreae MH, Andreae DA (2013) Regional anaesthesia to prevent chronic pain after surgery: a Cochrane systematic review and meta-analysis. Br J Anaesth 111:711–720CrossRefPubMedPubMedCentral Andreae MH, Andreae DA (2013) Regional anaesthesia to prevent chronic pain after surgery: a Cochrane systematic review and meta-analysis. Br J Anaesth 111:711–720CrossRefPubMedPubMedCentral
12.
go back to reference Sun EC et al (2017) Lack of Association between the use of nerve blockade and the risk of postoperative chronic opioid use among patients undergoing total knee arthroplasty: evidence from the Marketscan Database. Anesth Analg 125:999–1007CrossRefPubMed Sun EC et al (2017) Lack of Association between the use of nerve blockade and the risk of postoperative chronic opioid use among patients undergoing total knee arthroplasty: evidence from the Marketscan Database. Anesth Analg 125:999–1007CrossRefPubMed
14.
go back to reference Marcusa DP et al (2017) Prescription opioid use among opioid-naive women undergoing immediate breast reconstruction. Plast Reconstr Surg 140:1081–1090CrossRefPubMed Marcusa DP et al (2017) Prescription opioid use among opioid-naive women undergoing immediate breast reconstruction. Plast Reconstr Surg 140:1081–1090CrossRefPubMed
15.
go back to reference Jablonka EM et al (2017) Transversus abdominis plane blocks with single-dose liposomal bupivacaine in conjunction with a nonnarcotic pain regimen help reduce length of stay following abdominally based microsurgical breast reconstruction. Plastic Reconst Surg 140:240–251 (Lippincott Williams and Wilkins)CrossRef Jablonka EM et al (2017) Transversus abdominis plane blocks with single-dose liposomal bupivacaine in conjunction with a nonnarcotic pain regimen help reduce length of stay following abdominally based microsurgical breast reconstruction. Plastic Reconst Surg 140:240–251 (Lippincott Williams and Wilkins)CrossRef
16.
go back to reference Zhong T et al (2014) Transversus abdominis plane block reduces morphine consumption in the early postoperative period following microsurgical abdominal tissue breast reconstruction: a double-blind, placebo-controlled, randomized trial. Plastic Reconst Surg 134:870–878 (Lippincott Williams and Wilkins)CrossRef Zhong T et al (2014) Transversus abdominis plane block reduces morphine consumption in the early postoperative period following microsurgical abdominal tissue breast reconstruction: a double-blind, placebo-controlled, randomized trial. Plastic Reconst Surg 134:870–878 (Lippincott Williams and Wilkins)CrossRef
17.
go back to reference Hunter C et al (2017) Transversus abdominis plane block and free flap abdominal tissue breast reconstruction. Ann Plast Surg 78:254–259CrossRefPubMed Hunter C et al (2017) Transversus abdominis plane block and free flap abdominal tissue breast reconstruction. Ann Plast Surg 78:254–259CrossRefPubMed
19.
go back to reference Ho VT et al (2021) Increasing chronic opioid usage despite reduced prescriptions after vascular surgery. J Vasc Surg 74:e285–e286CrossRef Ho VT et al (2021) Increasing chronic opioid usage despite reduced prescriptions after vascular surgery. J Vasc Surg 74:e285–e286CrossRef
20.
go back to reference Abdou SA, Daar DA, Wilson SC, Thanik V (2020) Transversus abdominis plane blocks in microsurgical breast reconstruction: a systematic review and meta-analysis. J Reconstr Microsurg 36:353–361CrossRefPubMed Abdou SA, Daar DA, Wilson SC, Thanik V (2020) Transversus abdominis plane blocks in microsurgical breast reconstruction: a systematic review and meta-analysis. J Reconstr Microsurg 36:353–361CrossRefPubMed
21.
go back to reference Pan ZY et al (2020) The effect of transversus abdominis plane block on the chronic pain after colorectal surgery: a retrospective cohort study. BMC Anesthesiol 20:116CrossRefPubMedPubMedCentral Pan ZY et al (2020) The effect of transversus abdominis plane block on the chronic pain after colorectal surgery: a retrospective cohort study. BMC Anesthesiol 20:116CrossRefPubMedPubMedCentral
22.
go back to reference Jankovic Z, Ahmad N, Ravishankar N, Archer F (2008) Transversus abdominis plane block: how safe is it? Anesth Analg 107:1758–1759CrossRefPubMed Jankovic Z, Ahmad N, Ravishankar N, Archer F (2008) Transversus abdominis plane block: how safe is it? Anesth Analg 107:1758–1759CrossRefPubMed
23.
go back to reference Baeriswyl M, Kirkham KR, Kern C, Albrecht E (2015) The analgesic efficacy of ultrasound-guided transversus abdominis plane block in adult patients: a meta-analysis. Anesth Analg 121:1640–1654CrossRefPubMed Baeriswyl M, Kirkham KR, Kern C, Albrecht E (2015) The analgesic efficacy of ultrasound-guided transversus abdominis plane block in adult patients: a meta-analysis. Anesth Analg 121:1640–1654CrossRefPubMed
25.
26.
go back to reference Ziegelmann MJ et al (2019) Wide variation in opioid prescribing after urological surgery in tertiary care centers. Mayo Clin Proc 94:262–274CrossRefPubMed Ziegelmann MJ et al (2019) Wide variation in opioid prescribing after urological surgery in tertiary care centers. Mayo Clin Proc 94:262–274CrossRefPubMed
28.
go back to reference Butler PD, Wu LC (2015) Abdominal perforator vs. muscle sparing flaps for breast reconstruction. Gland surg 4:212–21221PubMedPubMedCentral Butler PD, Wu LC (2015) Abdominal perforator vs. muscle sparing flaps for breast reconstruction. Gland surg 4:212–21221PubMedPubMedCentral
29.
go back to reference Sun EC et al (2017) Association between concurrent use of prescription opioids and benzodiazepines and overdose retrospective analysis. BMJ (Online) 356:760 Sun EC et al (2017) Association between concurrent use of prescription opioids and benzodiazepines and overdose retrospective analysis. BMJ (Online) 356:760
31.
go back to reference Mellbye A, Svendsen K, Borchgrevink PC, Skurtveit S, Fredheim OMS (2012) Concomitant medication among persistent opioid users with chronic non-malignant pain. Acta Anaesthesiol Scand 56:1267–1276CrossRefPubMed Mellbye A, Svendsen K, Borchgrevink PC, Skurtveit S, Fredheim OMS (2012) Concomitant medication among persistent opioid users with chronic non-malignant pain. Acta Anaesthesiol Scand 56:1267–1276CrossRefPubMed
Metadata
Title
Transversus abdominus plane blocks do not reduce rates of postoperative prolonged opioid use following abdominally based autologous breast reconstruction: a nationwide longitudinal analysis
Authors
Arhana Chattopadhyay
Jennifer Krupa Shah
Pooja Yesantharao
Vy Thuy Ho
Clifford C. Sheckter
Rahim Nazerali
Publication date
04-10-2022
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Plastic Surgery / Issue 2/2023
Print ISSN: 0930-343X
Electronic ISSN: 1435-0130
DOI
https://doi.org/10.1007/s00238-022-01996-5

Other articles of this Issue 2/2023

European Journal of Plastic Surgery 2/2023 Go to the issue