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World Journal of Urology
Published in: World Journal of Urology 4/2021

01-04-2021 | Opioids | Original Article

Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double-blind, randomized, controlled trial

Authors: Mahboub Pouraghaei, Payman Moharamzadeh, Seyed Pouya Paknezhad, Zahra Vand Rajabpour, Hassan Soleimanpour

Published in: World Journal of Urology | Issue 4/2021

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Abstract

Background

Urinary stones are a common urologic problem that can be manifested as an intense pain, known as renal colic. Pain control is an important intervention for the emergency treatment of renal colic patients. Intranasal ketamine can form a crucial part of such interventions by offering a new route for a widely-used analgesic drug.

Methods

In a double-blind, randomized, clinical trial, adults with renal colic admitted to a tertiary hospital emergency department were examined. The intervention group received 1 mg/kg intranasal (IN) ketamine and 1 ml of saline as a placebo. The control group received 0.1 mg/kg intravenous (IV) morphine and four puffs of saline as the placebo. The pain score was measured on the Numerical Rating Scale (NRS) 0, 15, 30 and 60 min after the drug administration.

Results

A total of 184 patients enrolled in this study in two parallel groups. The two groups did not differ significantly in terms of pain intensity at the time of their referral (P = 0.489), 15 min post-dose (P = 0.204), 30 min post-dose (P = 0.978) and 60 min post-dose (P = 0.648).

Conclusion

IN ketamine is as effective as IV morphine for pain control in renal colic patients. No remarkable side-effects were observed for IN ketamine use in these patients.
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Metadata
Title
Intranasal ketamine versus intravenous morphine for pain management in patients with renal colic: a double-blind, randomized, controlled trial
Authors
Mahboub Pouraghaei
Payman Moharamzadeh
Seyed Pouya Paknezhad
Zahra Vand Rajabpour
Hassan Soleimanpour
Publication date
01-04-2021
Publisher
Springer Berlin Heidelberg
Published in
World Journal of Urology / Issue 4/2021
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI
https://doi.org/10.1007/s00345-020-03319-4

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