Skip to main content
Top
Published in: Pediatric Surgery International 1/2021

01-01-2021 | Opioids | Original Article

Cryoablation is associated with shorter length of stay and reduced opioid use in pectus excavatum repair

Authors: R. Luke Rettig, Andrew G. Rudikoff, Hoi Yee Annie Lo, Donald B. Shaul, Franklin M. Banzali, Antonio Hernandez Conte, Roman M. Sydorak

Published in: Pediatric Surgery International | Issue 1/2021

Login to get access

Abstract

Purpose

The use of intercostal nerve cryoablation (INC) is becoming increasingly common in patients undergoing pectus excavatum (PE) repair. This study sought to evaluate the use of INC compared to traditional use of thoracic epidural (TE).

Methods

A retrospective review of 79 patients undergoing PE repair with either INC or TE from May 2009 to December 2019 was conducted. The operations were performed by four surgeons who worked together at four different hospitals and have the same standardized practice. The primary outcome measure was hospital length of stay (LOS). Secondary variables included surgical time, total operating room time, operating room time cost, total hospital cost, inpatient opioid use, long-term opioid use after discharge, and postoperative complications.

Results

LOS decreased to 2.5 days in the INC group compared to 5 days in the TE group (p < 0.0001). Surgical time was increased in the INC group, but there was no difference in total OR time. The INC group experienced significantly lower hospital costs. Total hospital opioid administration was significantly lower in INC group, and there was a significant decrease in long-term opioid use in the INC group.

Conclusions

INC is a newer modality that decreases LOS, controls pain, and results in overall cost savings. We recommend that INC be included in the current practice for postoperative pain control in PE patients undergoing Nuss procedure.
Literature
1.
go back to reference Fokin AA, Steuerwald NM, Ahrens WA, Allen KE (2009) Anatomical, histologic, and genetic characteristics of congenital chest wall deformities. Semin Thorac Cardiovasc Surg 21(1):44–57CrossRef Fokin AA, Steuerwald NM, Ahrens WA, Allen KE (2009) Anatomical, histologic, and genetic characteristics of congenital chest wall deformities. Semin Thorac Cardiovasc Surg 21(1):44–57CrossRef
2.
go back to reference Mao YZ, Tang S, Li S (2017) Comparison of the Nuss versus Ravitch procedure for pectus excavatum repair: an updated meta-analysis. J Pediatr Surg 52(10):1545–1552CrossRef Mao YZ, Tang S, Li S (2017) Comparison of the Nuss versus Ravitch procedure for pectus excavatum repair: an updated meta-analysis. J Pediatr Surg 52(10):1545–1552CrossRef
3.
go back to reference Graves CE, Moyer J, Zobel MJ, Mora R, Smith D, O’Day M, Padilla BE (2019) Intraoperative intercostal nerve cryoablation during the Nuss procedure reduces length of stay and opioid requirement: a randomized clinical trial. J Pediatr Surg 54(11):2250–2256CrossRef Graves CE, Moyer J, Zobel MJ, Mora R, Smith D, O’Day M, Padilla BE (2019) Intraoperative intercostal nerve cryoablation during the Nuss procedure reduces length of stay and opioid requirement: a randomized clinical trial. J Pediatr Surg 54(11):2250–2256CrossRef
4.
go back to reference Koh JC, Song Y, Kim SY, Park S, Ko SH, Han DW (2017) Postoperative pain and patient-controlled epidural analgesia-related adverse effects in young and elderly patients: a retrospective analysis of 2435 patients. J Pain Res 10:897–990CrossRef Koh JC, Song Y, Kim SY, Park S, Ko SH, Han DW (2017) Postoperative pain and patient-controlled epidural analgesia-related adverse effects in young and elderly patients: a retrospective analysis of 2435 patients. J Pain Res 10:897–990CrossRef
5.
go back to reference Stroud AM, Tulanont DD, Coates TE, Goodney PP, Croitoru DP (2014) Epidural analgesia versus intravenous patient-controlled analgesia following minimally invasive pectus excavatum repair: a systematic review and meta-analysis. J Pediatr Surg 49(5):798–806CrossRef Stroud AM, Tulanont DD, Coates TE, Goodney PP, Croitoru DP (2014) Epidural analgesia versus intravenous patient-controlled analgesia following minimally invasive pectus excavatum repair: a systematic review and meta-analysis. J Pediatr Surg 49(5):798–806CrossRef
6.
go back to reference St. Peter SD, Weesner KA, Weissend EE, Sharp SW, Valusek PA, Sharp RJ, Snyder CL, Holcomb GW, Ostlie DJ, (2012) Epidural vs patient-controlled analgesia for postoperative pain after pectus excavatum repair: a prospective, randomized trial. J Pediatr Surg 47(1):148–155CrossRef St. Peter SD, Weesner KA, Weissend EE, Sharp SW, Valusek PA, Sharp RJ, Snyder CL, Holcomb GW, Ostlie DJ, (2012) Epidural vs patient-controlled analgesia for postoperative pain after pectus excavatum repair: a prospective, randomized trial. J Pediatr Surg 47(1):148–155CrossRef
7.
go back to reference Lukosiene L, Rugyte DC, Macas A, Kalibatiene L, Malcius D, Barauskas V (2013) Postoperative pain management in pediatric patients undergoing minimally invasive repair of pectus excavatum: the role of intercostal block. J Pediatr Surg 48(12):2425–2430CrossRef Lukosiene L, Rugyte DC, Macas A, Kalibatiene L, Malcius D, Barauskas V (2013) Postoperative pain management in pediatric patients undergoing minimally invasive repair of pectus excavatum: the role of intercostal block. J Pediatr Surg 48(12):2425–2430CrossRef
8.
go back to reference Beltran R, Veneziano G, Bhalla T, Kenney B, Tumin D, Bissonnette B, Tobias JD (2017) Postoperative pain management in patients undergoing thoracoscopic repair of pectus excavatum: a retrospective analysis of opioid consumption and adverse effects in adolescents. Saudi J Anaesth 11(4):427CrossRef Beltran R, Veneziano G, Bhalla T, Kenney B, Tumin D, Bissonnette B, Tobias JD (2017) Postoperative pain management in patients undergoing thoracoscopic repair of pectus excavatum: a retrospective analysis of opioid consumption and adverse effects in adolescents. Saudi J Anaesth 11(4):427CrossRef
9.
go back to reference St Peter SD, Weesner KA, Sharp RJ, Sharp SW, Ostlie DJ, Holcomb GW (2008) Is epidural anesthesia truly the best pain management strategy after minimally invasive pectus excavatum repair? J Pediatr Surg 43(1):79–82CrossRef St Peter SD, Weesner KA, Sharp RJ, Sharp SW, Ostlie DJ, Holcomb GW (2008) Is epidural anesthesia truly the best pain management strategy after minimally invasive pectus excavatum repair? J Pediatr Surg 43(1):79–82CrossRef
10.
go back to reference Litz CN, Farach SM, Fernandez AM, Elliott R, Dolan J, Nelson W, Walford NE, Snyder C, Jacobs JP, Amankwah EK, Danielson PD, Chandler NM (2017) Enhancing recovery after minimally invasive repair of pectus excavatum. Pediatr Surg Int 33(10):1123–1129CrossRef Litz CN, Farach SM, Fernandez AM, Elliott R, Dolan J, Nelson W, Walford NE, Snyder C, Jacobs JP, Amankwah EK, Danielson PD, Chandler NM (2017) Enhancing recovery after minimally invasive repair of pectus excavatum. Pediatr Surg Int 33(10):1123–1129CrossRef
11.
go back to reference Man JY, Gurnaney HG, Dubow SR, DiMaggio TJ, Kroeplin GR, Adzick NS, Muhly WT (2017) A retrospective comparison of thoracic epidural infusion and multimodal analgesia protocol for pain management following the minimally invasive repair of pectus excavatum. Paediatr Anesth 27(12):1227–1234CrossRef Man JY, Gurnaney HG, Dubow SR, DiMaggio TJ, Kroeplin GR, Adzick NS, Muhly WT (2017) A retrospective comparison of thoracic epidural infusion and multimodal analgesia protocol for pain management following the minimally invasive repair of pectus excavatum. Paediatr Anesth 27(12):1227–1234CrossRef
12.
go back to reference Keller BA, Kabagambe SK, Becker JC, Chen YJ, Goodman LF, Clark-Wronski JM, Furukawa K, Stark RA, Rahm AL, Hirose S, Raff GW (2016) Intercostal nerve cryoablation versus thoracic epidural catheters for postoperative analgesia following pectus excavatum repair: preliminary outcomes in twenty-six cryoablation patients. J Pediatr Surg 51(12):2033–2038CrossRef Keller BA, Kabagambe SK, Becker JC, Chen YJ, Goodman LF, Clark-Wronski JM, Furukawa K, Stark RA, Rahm AL, Hirose S, Raff GW (2016) Intercostal nerve cryoablation versus thoracic epidural catheters for postoperative analgesia following pectus excavatum repair: preliminary outcomes in twenty-six cryoablation patients. J Pediatr Surg 51(12):2033–2038CrossRef
14.
go back to reference Nuss D, Obermeyer RJ, Kelly RE (2016) Nuss bar procedure: past, present and future. Ann Cardiothorac Surg 5(5):422CrossRef Nuss D, Obermeyer RJ, Kelly RE (2016) Nuss bar procedure: past, present and future. Ann Cardiothorac Surg 5(5):422CrossRef
15.
go back to reference Loftus PD, Elder CT, Russell KW, Spanos SP, Barnhart DC, Scaife ER, Skarda DE, Rollins MD, Meyers RL (2016) Paravertebral regional blocks decrease length of stay following surgery for pectus excavatum in children. J Pediatr Surg 51(1):149–153CrossRef Loftus PD, Elder CT, Russell KW, Spanos SP, Barnhart DC, Scaife ER, Skarda DE, Rollins MD, Meyers RL (2016) Paravertebral regional blocks decrease length of stay following surgery for pectus excavatum in children. J Pediatr Surg 51(1):149–153CrossRef
16.
go back to reference Melnick GA, Fonkych K (2016) Hospital prices increase in California, especially among hospitals in the largest multi-hospital systems. Inquiry 53:0046958016651555PubMedPubMedCentral Melnick GA, Fonkych K (2016) Hospital prices increase in California, especially among hospitals in the largest multi-hospital systems. Inquiry 53:0046958016651555PubMedPubMedCentral
17.
go back to reference Weissler EH, Sanati-Mehrizy P, Massenburg B, Jenny H, Taub PJ, Midulla PS (2016) Abstract complications, length of stay, and economic burden among children undergoing pectus excavatum repair. Plast Reconstr Surg Glob Open 4(9):198–199CrossRef Weissler EH, Sanati-Mehrizy P, Massenburg B, Jenny H, Taub PJ, Midulla PS (2016) Abstract complications, length of stay, and economic burden among children undergoing pectus excavatum repair. Plast Reconstr Surg Glob Open 4(9):198–199CrossRef
18.
go back to reference Lloyd J, Barnard J, Glynn C (1976) Cryoanalgesia: a new approach to pain relief. Lancet 308(7992):932–934CrossRef Lloyd J, Barnard J, Glynn C (1976) Cryoanalgesia: a new approach to pain relief. Lancet 308(7992):932–934CrossRef
19.
go back to reference Katz J, Nelson W, Forest R, Bruce D (1980) Cryoanalgesia for post-thoracotomy pain. Lancet 315(8167):512–513CrossRef Katz J, Nelson W, Forest R, Bruce D (1980) Cryoanalgesia for post-thoracotomy pain. Lancet 315(8167):512–513CrossRef
20.
go back to reference Roberts D, Pizzarelli G, Lepore V, Al-Khaja N, Belboul A, Dernevik L (1988) Reduction of post-thoracotomy pain by cryotherapy of intercostal nerves. Scand J Thorac Cardiovasc Surg 22(2):127–130CrossRef Roberts D, Pizzarelli G, Lepore V, Al-Khaja N, Belboul A, Dernevik L (1988) Reduction of post-thoracotomy pain by cryotherapy of intercostal nerves. Scand J Thorac Cardiovasc Surg 22(2):127–130CrossRef
21.
go back to reference Papic JC, Finnell SME, Howenstein AM, Breckler F, Leys CM (2014) Postoperative opioid analgesic use after Nuss versus Ravitch pectus excavatum repair. J Pediatr Surg 49(6):919–923CrossRef Papic JC, Finnell SME, Howenstein AM, Breckler F, Leys CM (2014) Postoperative opioid analgesic use after Nuss versus Ravitch pectus excavatum repair. J Pediatr Surg 49(6):919–923CrossRef
22.
go back to reference Hall Burton DM, Boretsky KR (2014) A comparison of paravertebral nerve block catheters and thoracic epidural catheters for postoperative analgesia following the Nuss procedure for pectus excavatum repair. Paediatr Anaesth 24(5):516–520CrossRef Hall Burton DM, Boretsky KR (2014) A comparison of paravertebral nerve block catheters and thoracic epidural catheters for postoperative analgesia following the Nuss procedure for pectus excavatum repair. Paediatr Anaesth 24(5):516–520CrossRef
23.
go back to reference Graves C, Idowu O, Lee S, Padilla B, Kim S (2017) Intraoperative cryoanalgesia for managing pain after the Nuss procedure. J Pediatr Surg 52(6):920–924CrossRef Graves C, Idowu O, Lee S, Padilla B, Kim S (2017) Intraoperative cryoanalgesia for managing pain after the Nuss procedure. J Pediatr Surg 52(6):920–924CrossRef
24.
go back to reference Erinjeri JP, Clark TW (2010) Cryoablation: mechanism of action and devices. J Vasc Interv Radiol 21(8 Suppl):S187–S191CrossRef Erinjeri JP, Clark TW (2010) Cryoablation: mechanism of action and devices. J Vasc Interv Radiol 21(8 Suppl):S187–S191CrossRef
25.
go back to reference Zobel MJ, Ewbank C, Mora R, Idowu O, Kim S, Padilla BE (2020) The incidence of neuropathic pain after intercostal cryoablation during the Nuss procedure. Pediatr Surg Int 36(3):317–324CrossRef Zobel MJ, Ewbank C, Mora R, Idowu O, Kim S, Padilla BE (2020) The incidence of neuropathic pain after intercostal cryoablation during the Nuss procedure. Pediatr Surg Int 36(3):317–324CrossRef
Metadata
Title
Cryoablation is associated with shorter length of stay and reduced opioid use in pectus excavatum repair
Authors
R. Luke Rettig
Andrew G. Rudikoff
Hoi Yee Annie Lo
Donald B. Shaul
Franklin M. Banzali
Antonio Hernandez Conte
Roman M. Sydorak
Publication date
01-01-2021
Publisher
Springer Berlin Heidelberg
Keywords
Opioids
Opioids
Published in
Pediatric Surgery International / Issue 1/2021
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI
https://doi.org/10.1007/s00383-020-04778-x

Other articles of this Issue 1/2021

Pediatric Surgery International 1/2021 Go to the issue