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Pain and Therapy
Published in: Pain and Therapy 3/2022

Open Access 27-05-2022 | Opioids | Commentary

Commentary: Interpreting Data of Celiac Plexus Block in Patients with Pancreatic Pain: Timing, Patients, Survival

Author: Sebastiano Mercadante

Published in: Pain and Therapy | Issue 3/2022

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Abstract

Although celiac plexus block (CPB) is a well known technique that has been performed for years, only in the last 30 years controlled studies, demonstrated its efficacy and safety. A historical pathway of literature regarding CPB and a critical analysis may help understand some points which remain still controversial, for a better interpretation of data.
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Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.CrossRef
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Mercadante S, Klepstad P, Kurita GP, Sjøgren P, Giarratano A. Sympathetic blocks for visceral cancer pain management: A systematic review and EAPC recommendations. European Palliative Care Research Collaborative (EPCRC). Crit Rev Oncol Hematol. 2015;96:577–83.
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Mercadante S. Celiac plexus block versus analgesics in pancreatic cancer pain. Pain. 1993;52:187–92.CrossRef
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Kawamata M, Ishitani K, Ishikawa K, Sasaki H, Ota K, Omote K, Namiki A. Comparison between celiac plexus block and morphine treatment on quality of life in patients with pancreatic cancer pain. Pain. 1996;64:597–602.CrossRef
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Staats PS, Hekmat H, Sauter P, Lillemoe K. The effects of alcohol celiac plexus block, pain, and mood on longevity in patients with unresectable pancreatic cancer: a double-blind, randomized, placebo-controlled study. Pain Med. 2001;2:28–34.CrossRef
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Wyse JM, Carone M, Paquin SC, Usatii M, Sahai AV. Randomized, double-blind, controlled trial of early endoscopic ultrasound-guided celiac plexus neurolysis to prevent pain progression in patients with newly diagnosed, painful, inoperable pancreatic cancer. J Clin Oncol. 2001;26:3541–6.
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Okuyama M, Shibata T, Morita T, Kitada M, Tukahara Y, Fukushima Y, Ikeda K, Fuzita J, Shimano T. A comparison of intraoperative celiac plexus block with pharmacological therapy as a treatment for pain of unresectable pancreatic cancer. J Hepatobiliary Pancreat Surg. 2002;9:372–5.CrossRef
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Wong GY, Schroeder DR, Carns PE, Wilson JL, Martin DP, Kinney MO, Mantilla CB, Warner DO. Effect of neurolytic celiac plexus block on pain relief, quality of life, and survival in patients with unresectable pancreatic cancer. A randomized controlled trial. JAMA. 2004;291:1092–9.CrossRef
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Zhang C, Zhang T, Guo Y, Yang L, He M, Shi J, Ni J. Effect of neurolytic celiac plexus block guided by computerized tomography on pancreatic cancer pain. Dig Dis Sci. 2008;53:856–60.CrossRef
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Johnson CD, Berry DP, Harris S, Pickering RM, Davis C, George S, Imrie CW, Neoptolemos JP, Sutton R. An open randomized comparison of clinical effectiveness of protocol-driven opioid analgesia, celiac plexus block or thoracoscopic splanchnicectomy for pain management in patients with pancreatic and other abdominal malignancies. Pancreatology. 2009;9(6):755–63.CrossRef
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Amr Y, Makharita MY. Comparative study between 2 protocols formanagement of severe pain in patients with unresectable pancreatic pain oneyear follow-up. Clin J Pain. 2013;29:807–13.CrossRef
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Metadata
Title
Commentary: Interpreting Data of Celiac Plexus Block in Patients with Pancreatic Pain: Timing, Patients, Survival
Author
Sebastiano Mercadante
Publication date
27-05-2022
Publisher
Springer Healthcare
Published in
Pain and Therapy / Issue 3/2022
Print ISSN: 2193-8237
Electronic ISSN: 2193-651X
DOI
https://doi.org/10.1007/s40122-022-00396-8

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