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Published in: BMC Medicine 1/2014

Open Access 01-12-2014 | Editorial

Open questions in autoimmunity: discussions from the 2013 Controversies in Rheumatology and Autoimmunity Meeting

Authors: Carlo Selmi, Yehuda Shoenfeld

Published in: BMC Medicine | Issue 1/2014

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Abstract

The recent CORA (Controversies in Rheumatology and Autoimmunity) meeting held in 2013 represented a unique opportunity for rheumatologists to address several topics. Among these, four topics include: (i) the role of epigenetic changes in the pathogenesis of rheumatoid arthritis (RA), as shown by studies in monozygotic twins; (ii) the cardiovascular and atherosclerotic risk in patients with RA treated with biologics; (iii) the use of new biomarkers for the diagnosis and follow-up of RA and other autoimmune diseases, as represented by the new automatic machines for anti-nuclear antibodies detection, or ultrasound imaging to follow RA progression; and (iv) the latest guidelines on how to use and manage biologic therapies in RA and other autoimmune diseases, such as lupus. In summary, we will herein present these topics of discussion and underline the conclusions obtained by rheumatologists during the 2013 CORA Meeting.
Literature
1.
go back to reference Selmi C: Autoimmunity in 2012. Clin Rev Allergy Immunol. 2013, 45: 290-301. 10.1007/s12016-013-8386-7.CrossRefPubMed Selmi C: Autoimmunity in 2012. Clin Rev Allergy Immunol. 2013, 45: 290-301. 10.1007/s12016-013-8386-7.CrossRefPubMed
2.
go back to reference Bogdanos DP, Smyk DS, Rigopoulou EI, Mytilinaiou MG, Heneghan MA, Selmi C, Gershwin ME: Twin studies in autoimmune disease: genetics, gender and environment. J Autoimmun. 2012, 38: J156-J169. 10.1016/j.jaut.2011.11.003.CrossRefPubMed Bogdanos DP, Smyk DS, Rigopoulou EI, Mytilinaiou MG, Heneghan MA, Selmi C, Gershwin ME: Twin studies in autoimmune disease: genetics, gender and environment. J Autoimmun. 2012, 38: J156-J169. 10.1016/j.jaut.2011.11.003.CrossRefPubMed
3.
go back to reference Selmi C, Lu Q, Humble MC: Heritability versus the role of the environment in autoimmunity. J Autoimmun. 2012, 39: 249-252. 10.1016/j.jaut.2012.07.011.CrossRefPubMed Selmi C, Lu Q, Humble MC: Heritability versus the role of the environment in autoimmunity. J Autoimmun. 2012, 39: 249-252. 10.1016/j.jaut.2012.07.011.CrossRefPubMed
5.
go back to reference Costenbader KH, Gay S, Alarcon-Riquelme ME, Iaccarino L, Doria A: Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?. Autoimmun Rev. 2012, 11: 604-609. 10.1016/j.autrev.2011.10.022.CrossRefPubMed Costenbader KH, Gay S, Alarcon-Riquelme ME, Iaccarino L, Doria A: Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?. Autoimmun Rev. 2012, 11: 604-609. 10.1016/j.autrev.2011.10.022.CrossRefPubMed
6.
go back to reference De Santis M, Selmi C: The therapeutic potential of epigenetics in autoimmune diseases. Clin Rev Allergy Immunol. 2012, 42: 92-101. 10.1007/s12016-011-8293-8.CrossRefPubMed De Santis M, Selmi C: The therapeutic potential of epigenetics in autoimmune diseases. Clin Rev Allergy Immunol. 2012, 42: 92-101. 10.1007/s12016-011-8293-8.CrossRefPubMed
7.
go back to reference Liu Y, Li H, Xiao T, Lu Q: Epigenetics in immune-mediated pulmonary diseases. Clin Rev Allergy Immunol. 2013, 45: 314-330. 10.1007/s12016-013-8398-3.CrossRefPubMed Liu Y, Li H, Xiao T, Lu Q: Epigenetics in immune-mediated pulmonary diseases. Clin Rev Allergy Immunol. 2013, 45: 314-330. 10.1007/s12016-013-8398-3.CrossRefPubMed
8.
go back to reference Luo Y, Wang Y, Wang Q, Xiao R, Lu Q: Systemic sclerosis: genetics and epigenetics. J Autoimmun. 2013, 41: 161-167.CrossRefPubMed Luo Y, Wang Y, Wang Q, Xiao R, Lu Q: Systemic sclerosis: genetics and epigenetics. J Autoimmun. 2013, 41: 161-167.CrossRefPubMed
9.
go back to reference Ngalamika O, Zhang Y, Yin H, Zhao M, Gershwin ME, Lu Q: Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review. J Autoimmun. 2012, 39: 451-465. 10.1016/j.jaut.2012.09.002.CrossRefPubMed Ngalamika O, Zhang Y, Yin H, Zhao M, Gershwin ME, Lu Q: Epigenetics, autoimmunity and hematologic malignancies: a comprehensive review. J Autoimmun. 2012, 39: 451-465. 10.1016/j.jaut.2012.09.002.CrossRefPubMed
10.
go back to reference Thabet Y, Canas F, Ghedira I, Youinou P, Mageed RA, Renaudineau Y: Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?. J Autoimmun. 2012, 39: 154-160. 10.1016/j.jaut.2012.05.015.CrossRefPubMed Thabet Y, Canas F, Ghedira I, Youinou P, Mageed RA, Renaudineau Y: Altered patterns of epigenetic changes in systemic lupus erythematosus and auto-antibody production: is there a link?. J Autoimmun. 2012, 39: 154-160. 10.1016/j.jaut.2012.05.015.CrossRefPubMed
11.
go back to reference Zhang Y, Zhao M, Sawalha AH, Richardson B, Lu Q: Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus. J Autoimmun. 2013, 41: 92-99.CrossRefPubMed Zhang Y, Zhao M, Sawalha AH, Richardson B, Lu Q: Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus. J Autoimmun. 2013, 41: 92-99.CrossRefPubMed
13.
go back to reference Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH: Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients. J Autoimmun. 2013, 43: 78-84.CrossRefPubMedPubMedCentral Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH: Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients. J Autoimmun. 2013, 43: 78-84.CrossRefPubMedPubMedCentral
14.
go back to reference Pengo V, Banzato A, Denas G, Jose SP, Bison E, Hoxha A, Ruffatti A: Correct laboratory approach to APS diagnosis and monitoring. Autoimmun Rev. 2013, 12: 832-834. 10.1016/j.autrev.2012.11.008.CrossRefPubMed Pengo V, Banzato A, Denas G, Jose SP, Bison E, Hoxha A, Ruffatti A: Correct laboratory approach to APS diagnosis and monitoring. Autoimmun Rev. 2013, 12: 832-834. 10.1016/j.autrev.2012.11.008.CrossRefPubMed
15.
go back to reference Priori R, Scrivo R, Brandt J, Valerio M, Casadei L, Valesini G, Manetti C: Metabolomics in rheumatic diseases: the potential of an emerging methodology for improved patient diagnosis, prognosis, and treatment efficacy. Autoimmun Rev. 2013, 12: 1022-1030. 10.1016/j.autrev.2013.04.002.CrossRefPubMed Priori R, Scrivo R, Brandt J, Valerio M, Casadei L, Valesini G, Manetti C: Metabolomics in rheumatic diseases: the potential of an emerging methodology for improved patient diagnosis, prognosis, and treatment efficacy. Autoimmun Rev. 2013, 12: 1022-1030. 10.1016/j.autrev.2013.04.002.CrossRefPubMed
16.
go back to reference Rossi D, Russo A, Manna E, Binello G, Baldovino S, Sciascia S, Roccatello D: The role of nail-videocapillaroscopy in early diagnosis of scleroderma. Autoimmun Rev. 2013, 12: 821-825. 10.1016/j.autrev.2012.11.006.CrossRefPubMed Rossi D, Russo A, Manna E, Binello G, Baldovino S, Sciascia S, Roccatello D: The role of nail-videocapillaroscopy in early diagnosis of scleroderma. Autoimmun Rev. 2013, 12: 821-825. 10.1016/j.autrev.2012.11.006.CrossRefPubMed
17.
go back to reference Matsuura E, Lopez LR, Shoenfeld Y, Ames PR: β2-glycoprotein I and oxidative inflammation in early atherogenesis: a progression from innate to adaptive immunity?. Autoimmun Rev. 2012, 12: 241-249. 10.1016/j.autrev.2012.04.003.CrossRefPubMed Matsuura E, Lopez LR, Shoenfeld Y, Ames PR: β2-glycoprotein I and oxidative inflammation in early atherogenesis: a progression from innate to adaptive immunity?. Autoimmun Rev. 2012, 12: 241-249. 10.1016/j.autrev.2012.04.003.CrossRefPubMed
18.
go back to reference Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I: Inflammation, atherosclerosis, and psoriasis. Clin Rev Allergy Immunol. 2013, 44: 194-204. 10.1007/s12016-012-8308-0.CrossRefPubMed Siegel D, Devaraj S, Mitra A, Raychaudhuri SP, Raychaudhuri SK, Jialal I: Inflammation, atherosclerosis, and psoriasis. Clin Rev Allergy Immunol. 2013, 44: 194-204. 10.1007/s12016-012-8308-0.CrossRefPubMed
19.
go back to reference Singh RP, Massachi I, Manickavel S, Singh S, Rao NP, Hasan S, Mc Curdy DK, Sharma S, Wong D, Hahn BH, Rehimi H: The role of miRNA in inflammation and autoimmunity. Autoimmun Rev. 2013, 12: 1160-1165. 10.1016/j.autrev.2013.07.003.CrossRefPubMed Singh RP, Massachi I, Manickavel S, Singh S, Rao NP, Hasan S, Mc Curdy DK, Sharma S, Wong D, Hahn BH, Rehimi H: The role of miRNA in inflammation and autoimmunity. Autoimmun Rev. 2013, 12: 1160-1165. 10.1016/j.autrev.2013.07.003.CrossRefPubMed
20.
go back to reference Iborra M, Bernuzzi F, Invernizzi P, Danese S: MicroRNAs in autoimmunity and inflammatory bowel disease: crucial regulators in immune response. Autoimmun Rev. 2012, 11: 305-314. 10.1016/j.autrev.2010.07.002.CrossRefPubMed Iborra M, Bernuzzi F, Invernizzi P, Danese S: MicroRNAs in autoimmunity and inflammatory bowel disease: crucial regulators in immune response. Autoimmun Rev. 2012, 11: 305-314. 10.1016/j.autrev.2010.07.002.CrossRefPubMed
21.
go back to reference Saito Y, Saito H, Liang G, Friedman JM: Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review. Clin Rev Allergy Immunol. in press Saito Y, Saito H, Liang G, Friedman JM: Epigenetic alterations and microRNA misexpression in cancer and autoimmune diseases: a critical review. Clin Rev Allergy Immunol. in press
22.
go back to reference Ando Y, Yang GX, Kenny TP, Kawata K, Zhang W, Huang W, Leung PS, Lian ZX, Okazaki K, Ansari AA, He XS, Invernizzi P, Ridgway WM, Lu Q, Gershwin ME: Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-beta receptor type II mouse. J Autoimmun. 2013, 41: 111-119.CrossRefPubMedPubMedCentral Ando Y, Yang GX, Kenny TP, Kawata K, Zhang W, Huang W, Leung PS, Lian ZX, Okazaki K, Ansari AA, He XS, Invernizzi P, Ridgway WM, Lu Q, Gershwin ME: Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-beta receptor type II mouse. J Autoimmun. 2013, 41: 111-119.CrossRefPubMedPubMedCentral
23.
go back to reference Hahn BH, Grossman J, Chen W, McMahon M: The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia. J Autoimmun. 2007, 28: 69-75. 10.1016/j.jaut.2007.02.004.CrossRefPubMed Hahn BH, Grossman J, Chen W, McMahon M: The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia. J Autoimmun. 2007, 28: 69-75. 10.1016/j.jaut.2007.02.004.CrossRefPubMed
24.
go back to reference Soltesz P, Kerekes G, Der H, Szucs G, Szanto S, Kiss E, Bodolay E, Zeher M, Timar O, Szodoray P, Szegedi G, Szekanecz Z: Comparative assessment of vascular function in autoimmune rheumatic diseases: considerations of prevention and treatment. Autoimmun Rev. 2011, 10: 416-425. 10.1016/j.autrev.2011.01.004.CrossRefPubMed Soltesz P, Kerekes G, Der H, Szucs G, Szanto S, Kiss E, Bodolay E, Zeher M, Timar O, Szodoray P, Szegedi G, Szekanecz Z: Comparative assessment of vascular function in autoimmune rheumatic diseases: considerations of prevention and treatment. Autoimmun Rev. 2011, 10: 416-425. 10.1016/j.autrev.2011.01.004.CrossRefPubMed
25.
go back to reference Pengo V, Ruiz-Irastorza G, Denas G, Andreoli L, Khamashta M, Tincani A: High intensity anticoagulation in the prevention of the recurrence of arterial thrombosis in antiphospholipid syndrome: 'PROS' and 'CONS'. Autoimmun Rev. 2012, 11: 577-580. 10.1016/j.autrev.2011.10.016.CrossRefPubMed Pengo V, Ruiz-Irastorza G, Denas G, Andreoli L, Khamashta M, Tincani A: High intensity anticoagulation in the prevention of the recurrence of arterial thrombosis in antiphospholipid syndrome: 'PROS' and 'CONS'. Autoimmun Rev. 2012, 11: 577-580. 10.1016/j.autrev.2011.10.016.CrossRefPubMed
26.
27.
go back to reference Doria A, Dayer JM, Punzi L: Autoinflammatory diseases: how to put the fire inside the body out?. Autoimmun Rev. 2012, 12: 1-4. 10.1016/j.autrev.2012.07.013.CrossRefPubMed Doria A, Dayer JM, Punzi L: Autoinflammatory diseases: how to put the fire inside the body out?. Autoimmun Rev. 2012, 12: 1-4. 10.1016/j.autrev.2012.07.013.CrossRefPubMed
28.
go back to reference Rigante D: The fresco of autoinflammatory diseases from the pediatric perspective. Autoimmun Rev. 2012, 11: 348-356. 10.1016/j.autrev.2011.10.008.CrossRefPubMed Rigante D: The fresco of autoinflammatory diseases from the pediatric perspective. Autoimmun Rev. 2012, 11: 348-356. 10.1016/j.autrev.2011.10.008.CrossRefPubMed
29.
go back to reference Zen M, Gatto M, Domeneghetti M, Palma L, Borella E, Iaccarino L, Punzi L, Doria A: Clinical guidelines and definitions of autoinflammatory diseases: contrasts and comparisons with autoimmunity-a comprehensive review. Clin Rev Allergy Immunol. 2013, 45: 227-235. 10.1007/s12016-013-8355-1.CrossRefPubMed Zen M, Gatto M, Domeneghetti M, Palma L, Borella E, Iaccarino L, Punzi L, Doria A: Clinical guidelines and definitions of autoinflammatory diseases: contrasts and comparisons with autoimmunity-a comprehensive review. Clin Rev Allergy Immunol. 2013, 45: 227-235. 10.1007/s12016-013-8355-1.CrossRefPubMed
30.
go back to reference Chamorro AJ, Marcos M, Miron-Canelo JA, Cervera R, Espinosa G: Val247Leu beta2-glycoprotein-I allelic variant is associated with antiphospholipid syndrome: systematic review and meta-analysis. Autoimmun Rev. 2012, 11: 705-712. 10.1016/j.autrev.2011.12.006.CrossRefPubMed Chamorro AJ, Marcos M, Miron-Canelo JA, Cervera R, Espinosa G: Val247Leu beta2-glycoprotein-I allelic variant is associated with antiphospholipid syndrome: systematic review and meta-analysis. Autoimmun Rev. 2012, 11: 705-712. 10.1016/j.autrev.2011.12.006.CrossRefPubMed
31.
go back to reference de la Torre YM, Pregnolato F, D'Amelio F, Grossi C, Di Simone N, Pasqualini F, Nebuloni M, Chen P, Pierangeli S, Bassani N, Ambrogi F, Borghi MO, Vecchi A, Locati M, Meroni PL: Anti-phospholipid induced murine fetal loss: novel protective effect of a peptide targeting the beta2 glycoprotein I phospholipid-binding site, Implications for human fetal loss. J Autoimmun. 2012, 38: J209-J215. 10.1016/j.jaut.2011.11.009.CrossRefPubMed de la Torre YM, Pregnolato F, D'Amelio F, Grossi C, Di Simone N, Pasqualini F, Nebuloni M, Chen P, Pierangeli S, Bassani N, Ambrogi F, Borghi MO, Vecchi A, Locati M, Meroni PL: Anti-phospholipid induced murine fetal loss: novel protective effect of a peptide targeting the beta2 glycoprotein I phospholipid-binding site, Implications for human fetal loss. J Autoimmun. 2012, 38: J209-J215. 10.1016/j.jaut.2011.11.009.CrossRefPubMed
32.
go back to reference Mahler M, Norman GL, Meroni PL, Khamashta M: Autoantibodies to domain 1 of beta 2 glycoprotein 1: a promising candidate biomarker for risk management in antiphospholipid syndrome. Autoimmun Rev. 2012, 12: 313-317. 10.1016/j.autrev.2012.05.006.CrossRefPubMed Mahler M, Norman GL, Meroni PL, Khamashta M: Autoantibodies to domain 1 of beta 2 glycoprotein 1: a promising candidate biomarker for risk management in antiphospholipid syndrome. Autoimmun Rev. 2012, 12: 313-317. 10.1016/j.autrev.2012.05.006.CrossRefPubMed
33.
go back to reference Tozzoli R, Villalta D: Autoantibody profiling of patients with antiphospholipid syndrome using an automated multiplexed immunoassay system. Autoimmun Rev. 2014, 13: 59-63. 10.1016/j.autrev.2013.08.007.CrossRefPubMed Tozzoli R, Villalta D: Autoantibody profiling of patients with antiphospholipid syndrome using an automated multiplexed immunoassay system. Autoimmun Rev. 2014, 13: 59-63. 10.1016/j.autrev.2013.08.007.CrossRefPubMed
34.
go back to reference Conrad K, Roggenbuck D, Reinhold D, Sack U: Autoantibody diagnostics in clinical practice. Autoimmun Rev. 2012, 11: 207-211. 10.1016/j.autrev.2011.05.014.CrossRefPubMed Conrad K, Roggenbuck D, Reinhold D, Sack U: Autoantibody diagnostics in clinical practice. Autoimmun Rev. 2012, 11: 207-211. 10.1016/j.autrev.2011.05.014.CrossRefPubMed
35.
go back to reference Villalta D, Imbastaro T, Di Giovanni S, Lauriti C, Gabini M, Turi MC, Bizzaro N: Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis. Autoimmun Rev. 2012, 12: 114-120. 10.1016/j.autrev.2012.07.005.CrossRefPubMed Villalta D, Imbastaro T, Di Giovanni S, Lauriti C, Gabini M, Turi MC, Bizzaro N: Diagnostic accuracy and predictive value of extended autoantibody profile in systemic sclerosis. Autoimmun Rev. 2012, 12: 114-120. 10.1016/j.autrev.2012.07.005.CrossRefPubMed
37.
go back to reference van Sijl AM, Peters MJ, Knol DL, de Vet RH, Sattar N, Dijkmans BA, Smulders YM, Nurmohamed MT: The effect of TNF-alpha blocking therapy on lipid levels in rheumatoid arthritis: a meta-analysis. Semin Arthritis Rheum. 2011, 41: 393-400. 10.1016/j.semarthrit.2011.04.003.CrossRefPubMed van Sijl AM, Peters MJ, Knol DL, de Vet RH, Sattar N, Dijkmans BA, Smulders YM, Nurmohamed MT: The effect of TNF-alpha blocking therapy on lipid levels in rheumatoid arthritis: a meta-analysis. Semin Arthritis Rheum. 2011, 41: 393-400. 10.1016/j.semarthrit.2011.04.003.CrossRefPubMed
39.
go back to reference Gatto M, Kiss E, Naparstek Y, Doria A: In/Off label use of biologic therapy in systemic lupus erythematosus. BMC Med. 2014, 12: 30-10.1186/1741-7015-12-30.CrossRefPubMedPubMedCentral Gatto M, Kiss E, Naparstek Y, Doria A: In/Off label use of biologic therapy in systemic lupus erythematosus. BMC Med. 2014, 12: 30-10.1186/1741-7015-12-30.CrossRefPubMedPubMedCentral
40.
go back to reference Mocsai A, Kovacs L, Gergely P: What is the future of targeted therapy in rheumatology: biologics or small molecules?. BMC Med. 2014, 12: 43-10.1186/1741-7015-12-43.CrossRefPubMedPubMedCentral Mocsai A, Kovacs L, Gergely P: What is the future of targeted therapy in rheumatology: biologics or small molecules?. BMC Med. 2014, 12: 43-10.1186/1741-7015-12-43.CrossRefPubMedPubMedCentral
41.
go back to reference Meroni PL, Bizzaro N, Cavazzana I, Borghi MO, Tincani A: Automated tests of ANA immunofluorescence as throughput autoantibody detection technology: strengths and limitations. BMC Med. 2014, 12: 38-10.1186/1741-7015-12-38.CrossRefPubMedPubMedCentral Meroni PL, Bizzaro N, Cavazzana I, Borghi MO, Tincani A: Automated tests of ANA immunofluorescence as throughput autoantibody detection technology: strengths and limitations. BMC Med. 2014, 12: 38-10.1186/1741-7015-12-38.CrossRefPubMedPubMedCentral
42.
go back to reference Melegari A, Bonaguri C, Russo A, Luisita B, Trenti T, Lippi G: A comparative study on the reliability of an automated system for the evaluation of cell-based indirect immunofluorescence. Autoimmun Rev. 2012, 11: 713-716. 10.1016/j.autrev.2011.12.010.CrossRefPubMed Melegari A, Bonaguri C, Russo A, Luisita B, Trenti T, Lippi G: A comparative study on the reliability of an automated system for the evaluation of cell-based indirect immunofluorescence. Autoimmun Rev. 2012, 11: 713-716. 10.1016/j.autrev.2011.12.010.CrossRefPubMed
43.
go back to reference Bizzaro N, Antico A, Platzgummer S, Tonutti E, Bassetti D, Pesente F, Tozzoli R, Tampoia M, Villalta D, Study Group on Autoimmune Diseases of the Italian Society of Laboratory Medicine I: Automated antinuclear immunofluorescence antibody screening: a comparative study of six computer-aided diagnostic systems. Autoimmun Rev. 2014, 13: 292-298. 10.1016/j.autrev.2013.10.015.CrossRefPubMed Bizzaro N, Antico A, Platzgummer S, Tonutti E, Bassetti D, Pesente F, Tozzoli R, Tampoia M, Villalta D, Study Group on Autoimmune Diseases of the Italian Society of Laboratory Medicine I: Automated antinuclear immunofluorescence antibody screening: a comparative study of six computer-aided diagnostic systems. Autoimmun Rev. 2014, 13: 292-298. 10.1016/j.autrev.2013.10.015.CrossRefPubMed
44.
go back to reference Koenig M, Dieude M, Senecal JL: Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies. Autoimmun Rev. 2008, 7: 588-593. 10.1016/j.autrev.2008.06.010.CrossRefPubMed Koenig M, Dieude M, Senecal JL: Predictive value of antinuclear autoantibodies: the lessons of the systemic sclerosis autoantibodies. Autoimmun Rev. 2008, 7: 588-593. 10.1016/j.autrev.2008.06.010.CrossRefPubMed
45.
go back to reference Moinzadeh P, Nihtyanova SI, Howell K, Ong VH, Denton CP: Impact of hallmark autoantibody reactivity on early diagnosis in scleroderma. Clin Rev Allergy Immunol. 2012, 43: 249-255. 10.1007/s12016-012-8331-1.CrossRefPubMed Moinzadeh P, Nihtyanova SI, Howell K, Ong VH, Denton CP: Impact of hallmark autoantibody reactivity on early diagnosis in scleroderma. Clin Rev Allergy Immunol. 2012, 43: 249-255. 10.1007/s12016-012-8331-1.CrossRefPubMed
46.
go back to reference Meroni PL, Schur PH: ANA screening: an old test with new recommendations. Ann Rheum Dis. 2010, 69: 1420-1422. 10.1136/ard.2009.127100.CrossRefPubMed Meroni PL, Schur PH: ANA screening: an old test with new recommendations. Ann Rheum Dis. 2010, 69: 1420-1422. 10.1136/ard.2009.127100.CrossRefPubMed
48.
go back to reference Shi J, van Veelen PA, Mahler M, Janssen GM, Drijfhout JW, Huizinga TW, Toes RE, Trouw LA: Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2014, 13: 225-230. 10.1016/j.autrev.2013.10.008.CrossRefPubMed Shi J, van Veelen PA, Mahler M, Janssen GM, Drijfhout JW, Huizinga TW, Toes RE, Trouw LA: Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun Rev. 2014, 13: 225-230. 10.1016/j.autrev.2013.10.008.CrossRefPubMed
49.
go back to reference Acharya NK, Nagele EP, Han M, Coretti NJ, DeMarshall C, Kosciuk MC, Boulos PA, Nagele RG: Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease. J Autoimmun. 2012, 38: 369-380. 10.1016/j.jaut.2012.03.004.CrossRefPubMed Acharya NK, Nagele EP, Han M, Coretti NJ, DeMarshall C, Kosciuk MC, Boulos PA, Nagele RG: Neuronal PAD4 expression and protein citrullination: possible role in production of autoantibodies associated with neurodegenerative disease. J Autoimmun. 2012, 38: 369-380. 10.1016/j.jaut.2012.03.004.CrossRefPubMed
50.
go back to reference Auger I, Charpin C, Balandraud N, Martin M, Roudier J: Autoantibodies to PAD4 and BRAF in rheumatoid arthritis. Autoimmun Rev. 2012, 11: 801-803. 10.1016/j.autrev.2012.02.009.CrossRefPubMed Auger I, Charpin C, Balandraud N, Martin M, Roudier J: Autoantibodies to PAD4 and BRAF in rheumatoid arthritis. Autoimmun Rev. 2012, 11: 801-803. 10.1016/j.autrev.2012.02.009.CrossRefPubMed
Metadata
Title
Open questions in autoimmunity: discussions from the 2013 Controversies in Rheumatology and Autoimmunity Meeting
Authors
Carlo Selmi
Yehuda Shoenfeld
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2014
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/1741-7015-12-50

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