Published in:
Open Access
01-06-2011 | Brief Report
One case of sporadic hemiplegic migraine with multiple pulmonary arteriovenous malformation
Authors:
Mianwang He, Shengyuan Yu, Guangyi Wang
Published in:
The Journal of Headache and Pain
|
Issue 3/2011
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Excerpt
Hemiplegic migraine is a rare variation of migraine with aura (MA) which should be classified as either familial hemiplegic migraine (FHM) or sporadic hemiplegic migraine (SHM) [
1]. SHM is defined as migraine attacks associated with some degree of motor weakness/hemiparesis during the aura phase and no first degree relative (parent, sibling or child) has identical attacks. FHM is the only migraine subtype for which a monogenic mode of inheritance (autosomal dominant) has been clearly established to be caused by mutations in any of the following three gene loci—CACNA1A, ATP1A2 and SCN 1A [
2,
3]. Some recent studies have identified involvement of these gene loci in SHM as well [
2,
3]. Moreover, SHM is more difficult to diagnose and often requires several investigations to rule out other possible diseases. Friberg et al. [
4] studied regional cerebral blood flow (rCBF) in three patients in whom hemiplegic migraine was induced by focal hypoperfusion developed in the frontal lobes and spread posteriorly. …
