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Anatomical Science International
Published in: Anatomical Science International 2/2018

01-03-2018 | Review Article

Oncostatin M in the development of metabolic syndrome and its potential as a novel therapeutic target

Authors: Tadasuke Komori, Yoshihiro Morikawa

Published in: Anatomical Science International | Issue 2/2018

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Abstract

Oncostatin M (OSM), a member of the IL-6 family of cytokines, plays an important role in various biologic actions, including cell growth, neuronal development, and inflammatory responses. Recently, we demonstrated the unique relationship between OSM and metabolic syndrome in mice. Mice lacking OSM receptor β subunit (OSMRβ−/− mice) exhibited late-onset obesity. Before the onset of obesity, adipose tissue inflammation and insulin resistance were observed in OSMRβ−/− mice. In addition, high-fat diet-induced metabolic disorders, including obesity, adipose tissue inflammation, insulin resistance, and hepatic steatosis, were aggravated in OSMRβ−/− mice compared to those in wild-type mice. Consistent with these findings, OSM treatment dramatically improved these metabolic disorders in the mouse model of metabolic syndrome. Interestingly, OSM directly changed the phenotypes of adipose tissue macrophages toward anti-inflammatory M2 type. Furthermore, fatty acid content in the hepatocytes was decreased by OSM through expression regulation of several key enzymes of hepatic lipid metabolism. These findings suggest that OSM is a novel therapeutic target for metabolic syndrome.
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Metadata
Title
Oncostatin M in the development of metabolic syndrome and its potential as a novel therapeutic target
Authors
Tadasuke Komori
Yoshihiro Morikawa
Publication date
01-03-2018
Publisher
Springer Singapore
Published in
Anatomical Science International / Issue 2/2018
Print ISSN: 1447-6959
Electronic ISSN: 1447-073X
DOI
https://doi.org/10.1007/s12565-017-0421-y

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