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01-10-2011 | Short Communication

Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6

Authors: Jane E. Libbey, Nikki J. Kennett, Karen S. Wilcox, H. Steve White, Robert S. Fujinami

Published in: Journal of NeuroVirology | Issue 5/2011

Abstract

Theiler’s murine encephalomyelitis virus infection of C57BL/6 mice results in acute behavioral seizures in 50% of the mice. Treatment of infected mice with minocycline or infection of interleukin (IL)-6-deficient chimeric mice results in a significant decrease in the number of mice developing seizures. However, in those mice that do develop seizures, the pathological changes (neuronal cell loss, inflammation [perivascular cuffing, gliosis, activated microglia/macrophages]), and the numbers of virus infected cells in minocycline-treated or IL-6-deficient chimeric mice are very similar. Therefore, once seizures develop, the pathological changes are consistent regardless of the treatment or genetic background.

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Title: Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6
Authors: Jane E. Libbey
Nikki J. Kennett
Karen S. Wilcox
H. Steve White
Robert S. Fujinami
Publication date: 01-10-2011
Publisher: Springer US
Published in: Journal of NeuroVirology / Issue 5/2011
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-011-0050-5

2024 ASCO Annual Meeting

Springer Medicine

Once initiated, viral encephalitis-induced seizures are consistent no matter the treatment or lack of interleukin-6

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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