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Osteoporosis International
Published in: Osteoporosis International 8/2005

01-08-2005 | Letter

On some osteoporosis analyses

Author: A. D. Tsakok

Published in: Osteoporosis International | Issue 8/2005

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Excerpt

The articles by Reginster et al. [1] and Bhattoa et al. [2] are flawed, because the analysis of variance and the two-sample t -tests or variations to it are inappropriate. The Central Limit Theorem justifies the normality assumed by these methods for mean inferences. The problem is that the two above methods also assume that the unknown variances of the groups of interest are equal. Since unknown variances need not be equal, both the analysis of variance and the two-sample t -tests are not generally applicable to comparing means. …
Literature
1.
Reginster JY, Meunier PJ (2003) Strontium ranelate phase 2 dose ranging studies: PEVOS and STRATOS studies. Osteoporos Int 14 [Suppl 3]:S56–S65
2.
Bhattoa HP, Bettembuk P, Balogh A, Szegedi G (2004) The effect of 1 year transdermal estrogen replacement therapy on bone mineral density and biochemical markers of bone turnover in osteopenic postmenopausal systemic erythematosus patients: a randomized double-blind, placebo-controlled trial. Osteoporos Int 15:396–404PubMed
3.
Kendall MG, Stuart A (1973) The advanced theory of statistics, vol 2. Charles Griffin, London, p 484
4.
Lehmann EL (1959) Testing statistical hypotheses. Wiley, New York, p 187
5.
Tsakok AD (1978) A solution to the generalized Behrens-Fisher problem. Metron 36:79
6.
Tsakok AD (2002) Comment on visual acuity. Ophthalmic Epidemiol 9:347PubMed
7.
Tsakok AD (1978) A test of fit satisfying some optimality criteria non-asymptotically. Metron 36:105
8.
Tsakok AD (1995) A generalization of the Borel-Cantelli lemma. Metron 53:25
9.
Tsakok AD (1987) Statistics and the unified field. AD Tsakok Mathematical Centre, London
Metadata
Title
On some osteoporosis analyses
Author
A. D. Tsakok
Publication date
01-08-2005
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 8/2005
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-005-1882-8

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