Published in:
01-09-2008 | IM - Case Record
Olanzapine metabolic side effects: a weight gain issue?
Published in: Internal and Emergency Medicine | Issue 3/2008
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Dr. Lucia Carulli, Dr. Stefania Rondinella: A 36-year-old white man was admitted to our internal medicine ward because of persistent polydipsia, polyuria and weight loss associated with an occasional finding of combined hyperlipidemia, hyperglycemia and glycosuria. Blood tests at the time of admission confirmed such abnormalities (Table 1).
Table 1
Most significant laboratory tests as related to olanzapine therapy
|
Before therapy
|
5 months after initiation of therapy
|
At the admission
|
1 week after discontinuation of therapy
|
6 months after discontinuation of therapy
|
|
|---|---|---|---|---|---|
|
Glycemia (mg/dl)
|
107
|
463
|
459
|
249
|
272
|
|
Chol-tot (mg/dl)
|
176
|
329
|
291
|
290
|
221
|
|
Chol-HDL (mg/dl)
|
40
|
28
|
33
|
35
|
43
|
|
Chol-LDL (mg/dl)
|
114
|
_
|
_
|
220
|
149
|
|
TG (mg/dl)
|
139
|
1,151
|
3,298
|
176
|
150
|
|
U-glucose (mg/dl)
|
0
|
8,497
|
8,497
|
652
|
536
|
|
U-proteins (mg/dl)
|
0
|
abs
|
abs
|
abs
|
10
|
|
U-ketons (mg/dl)
|
abs
|
>80
|
>80
|
abs
|
abs
|