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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-02-2012 | Glaucoma

Ocular response analyzer to assess corneal biomechanical properties in exfoliation syndrome and exfoliative glaucoma

Authors: Ali Bulent Cankaya, Alpaslan Anayol, Dilek Özcelik, Elif Demirdogen, Pelin Yilmazbas

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 2/2012

Abstract

Background

The aim of this work was to investigate the differences in corneal biomechanical parameters between healthy and exfoliation syndrome (EXS) and exfoliative glaucoma (EXG) patients.

Methods

Two hundred and forty-four eyes of 102 healthy, 64 EXS, and 78 EXG patients were included in the study. Corneal biomechanical parameters were measured using an ocular response analyzer (ORA). Central corneal thickness (CCT) was measured with an ultrasonic pachymeter. The differences in ORA parameters between study and control group participants were analyzed using Student’s t test.

Results

In healthy subjects, EXS and EXG eyes mean corneal hysteresis (CH) values were 9.4 ± 1.4 mmHg, 8.5 ± 1.5 mmHg and 6.9 ± 2.1 mmHg, respectively. The difference in mean CH between the EXG and the other two groups were statistically significant (p < 0.01 for both comparisons). CH was significantly lower in EXS patients than that of healthy eyes (p < 0.001). Mean corneal resistance factor (CRF) values were 9.8 ± 1.6 mmHg, 9.3 ± 1.8 mmHg and 9.5 ± 2.6 mmHg, respectively. Except for the difference between the control and EXS eyes (p = 0.004), no statistically significant difference was found between the groups in relation to mean CRF. There were no significant differences in CCT between the control eyes and exfoliative eyes with or without glaucoma.

Conclusions

In this study, CH was found to be significantly lower in eyes with exfoliation. Further studies are needed to establish the relationships between exfoliation, ocular biomechanics, and glaucoma.

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Title: Ocular response analyzer to assess corneal biomechanical properties in exfoliation syndrome and exfoliative glaucoma
Authors: Ali Bulent Cankaya
Alpaslan Anayol
Dilek Özcelik
Elif Demirdogen
Pelin Yilmazbas
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 2/2012
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-011-1793-7

At a glance: The STEP trials

Springer Medicine

Ocular response analyzer to assess corneal biomechanical properties in exfoliation syndrome and exfoliative glaucoma

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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