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European Journal of Pediatrics
Published in: European Journal of Pediatrics 9/2003

01-09-2003 | Research Letter

Occurrence of overwhelming gram-negative infections in splenectomised patients with thalassaemia major

Authors: Mardawig Alebouyeh, Farideh Moussavi

Published in: European Journal of Pediatrics | Issue 9/2003

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Excerpt

This report emphasises (1) the importance of the emergence of gram-negative organisms in the pathogenesis of overwhelming post-splenectomy infections in thalassaemics, irrespective of their age and splenectomy interval, (2) the necessity to start immediate intravenous treatment with broad spectrum antibiotics in febrile individuals and (3) to draw attention to the need of a well designed study of this problem and its prevention. …
Literature
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Bisharat N, Omari H, Lavi I, Raz R (2001) Risk of infection and death among post splenectomy patients. J Infect 43: 182–186CrossRefPubMed
2.
Borgna-Pignatti C, Rugolotto S, De Stefano P, Piga A, Di Gregorio F, Gamberini MR, Sabato V, Melevendi C, Cappellini MD, Verlato G (1998)Survival and disease complications in thalassemia major. Ann N Y Acad Sci 850: 227–231PubMed
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Eber SW, Langdorfer CM, Ditzig M ,Einhardt D, Stoh G, Soldan W, Schroter W, Tchernia G (1999) Frequency of very late fatal sepsis after splenectomy for hereditary spherocytosis: impact of insufficient antibody response to pneumococcal infection. Ann Hematol 78: 524–528CrossRef
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Hansen K, Singer OB (2001) Asplenic-hyposplenic overwhelming sepsis: post-splenectomy sepsis revisited. Pediatr Dev Pathol 4: 105–121CrossRefPubMed
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Infectious Disease and Immunization Committee, Canadian Pediatric Society (CPS) (1999) Prevention and therapy of bacterial infections for children with asplenia or hyposplenia. Pediatr Child Health 4: 417–421
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Piomelli S, Hart D, Graziano J, Grant G, Karpatkin M, McCarthy K (1985) Current strategies in the management of Cooley's anemia. Ann N Y Acad Sci 445: 256–267PubMed
Metadata
Title
Occurrence of overwhelming gram-negative infections in splenectomised patients with thalassaemia major
Authors
Mardawig Alebouyeh
Farideh Moussavi
Publication date
01-09-2003
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 9/2003
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-003-1253-4

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