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Journal of Occupational Medicine and Toxicology

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Open Access 01-12-2020 | Research

Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital

Authors: Ai Hori, Mari Shimura, Yutaka Iida, Kazuhiko Yamada, Kyoko Nohara, Takayuki Ichinose, Ai Yamashita, Junko Shirataki, Shotaro Hagiwara

Published in: Journal of Occupational Medicine and Toxicology | Issue 1/2020

Abstract

Background

Occupational exposure to chemotherapeutic agents in hospitals is a critical issue. Here, we focused on occupational exposure to platinum-based anti-cancer drugs (PDs) by evaluating platinum concentrations in hair and environmental workplace samples to monitor the risk among workers.

Methods

Hospital workers who dealt with or without PDs, patients treated with PDs, and non-medical office workers outside the hospital donated hair samples and completed a questionnaire regarding their history of handling PDs, including any incidents. Hair samples were collected and surface wipe sampling was performed in July 2010 and April 2015, before and after moving to a new building and introducing a revised safety program in August 2010. Samples were analyzed by inductively coupled plasma-mass spectrometry.

Results

Platinum concentrations in hair from PDs-handling workers was significantly higher than in non-PDs-handling workers (P = 0.045), although 50 times lower than that from PDs-treated patients. Platinum concentrations in the hospital environment had decreased at the second survey 5 years later but had not changed significantly in the hair samples from hospital workers.

Conclusion

Platinum concentrations in hair are likely dependent on the frequency of handling PDs. Reduced environmental contamination from PDs did not influence platinum levels in hospital workers’ hair. Continuous monitoring by measuring platinum concentrations in the environment and in hair would provide information regarding these issues.

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Connor TH, Lawson CC, Polovich M, McDiarmid MA. Reproductive health risks associated with occupational exposures to antineoplastic drugs in health care settings: a review of the evidence. J Occup Environ Med. 2014;56(9):901–10. https://doi.org/10.1097/JOM.0000000000000249.CrossRefPubMedPubMedCentral

Dranitsaris G, Johnston M, Poirier S, Schueller T, Milliken D, Green E, Zanke B. Are health care providers who work with cancer drugs at an increased risk for toxic events? A systematic review and meta-analysis of the literature. J Oncol Pharm Pract. 2005;11(2):69–78.CrossRef

Lawson CC, Rocheleau CM, Whelan EA, Lividoti Hibert EN, Grajewski B, Spiegelman D, Rich-Edwards JW. Occupational exposures among nurses and risk of spontaneous abortion. Am J Obstet Gynecol. 2012;206(4):327.e1–8. https://doi.org/10.1016/j.ajog.2011.12.030.CrossRef

Fransman W, Roeleveld N, Peelen S, de Kort W, Kromhout H, Heederik D. Nurses with dermal exposure to antineoplastic drugs: reproductive outcomes. Epidemiology. 2007;18(1):112–9. https://doi.org/10.1097/01.ede.0000246827.44093.c1.CrossRefPubMed

IARC Monographs on the identification of carcinogenic hazards to humans. Lyon: International Agency for Research on Cancer; 2020. https://monographs.iarc.fr/list-of-classifications. Accessed 8 Sept 2020.

Ziegler E, Mason HJ, Baxter PJ. Occupational exposure to cytotoxic drugs in two UK oncology wards. Occup Environ Med. 2002;59(9):608–12.CrossRef

Brouwers EE, Huitema AD, Bakker EN, Douma JW, Schimmel KJ, van Weringh G, de Wolf PJ, Schellens JH, Beijnen JH. Monitoring of platinum surface contamination in seven Dutch hospital pharmacies using inductively coupled plasma mass spectrometry. Int Arch Occup Environ Health. 2007;80(8):689–99. https://doi.org/10.1007/s00420-007-0181-4.CrossRefPubMedPubMedCentral

Yoshida J, Koda S, Nishida S, Yoshida T, Miyajima K, Kumagai S. Association between occupational exposure levels of antineoplastic drugs and work environment in five hospitals in Japan. J Oncol Pharm Pract. 2011;17(1):29–38. https://doi.org/10.1177/1078155210380485.CrossRefPubMed

Sottani C, Porro B, Imbriani M, Minoia C. Occupational exposure to antineoplastic drugs in four Italian health care settings. Toxicol Lett. 2012;213(1):107–15. https://doi.org/10.1016/j.toxlet.2011.03.028.CrossRefPubMed

10.

Nygren O, Lundgren C. Determination of platinum in workroom air and in blood and urine from nursing staff attending patients receiving cisplatin chemotherapy. Int Arch Occup Environ Health. 1997;70(3):209–14.CrossRef

11.

Tomkins J. Ensuring health care worker safety when handling hazardous drugs: the joint position statement from the Oncology Nursing Society, the American Society of Clinical Oncology, and the hematology/oncology pharmacy association. J Oncol Pract. 2015;11(4):278–9. https://doi.org/10.1200/JOP.2015.004978.CrossRefPubMed

12.

National Institute for Occupational Safety and Health: Preventing occupational exposures to antineoplastic and other hazardous drugs in healthcare settings. 2004.

13.

Coelho P, Costa S, Silva S, Walter A, Ranville J, Sousa AC, Costa C, Coelho M, Garcia-Leston J, Pastorinho MR, Laffon B, Pasaro E, Harrington C, Taylor A, Teixeira JP. Metal (loid) levels in biological matrices from human populations exposed to mining contamination--Panasqueira mine (Portugal). J Toxicol Environ Health A. 2012;75(13–15):893–908. https://doi.org/10.1080/15287394.2012.690705.CrossRefPubMed

14.

Grabeklis AR, Skalny AV, Nechiporenko SP, Lakarova EV. Indicator ability of biosubstances in monitoring the moderate occupational exposure to toxic metals. J Trace Elem Med Biol. 2011;25(Suppl 1):S41–4. https://doi.org/10.1016/j.jtemb.2010.10.014.CrossRefPubMed

15.

Li P, Feng X, Qiu G, Wan Q. Hair can be a good biomarker of occupational exposure to mercury vapor: simulated experiments and field data analysis. Sci Total Environ. 2011;409(20):4484–8. https://doi.org/10.1016/j.scitotenv.2011.06.045.CrossRefPubMed

16.

Stadlbauer C, Prohaska T, Reiter C, Knaus A, Stingeder G. Time-resolved monitoring of heavy-metal intoxication in single hair by laser ablation ICP-DRCMS. Anal Bioanal Chem. 2005;383(3):500–8. https://doi.org/10.1007/s00216-005-3283-4.CrossRefPubMed

17.

Pozebon D. Monitoring of platinum in a single hair by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) after cisplatin treatment for cancer. Int J Mass Spectrometry. 2008;272(1):57–62.CrossRef

18.

Japanese Industrial Standards Committee: General rules for high frequency plasma mass spectrometry. 2005; JISK0133.

19.

U. S. Environmental Protection Agency. Data Quality Assessment: Statistical Methods for Practitioners. Washington DC: EPA QA/G-9S; 2006. p. 130–5.

20.

Kiilunen M, Aitio A. Platinum. In: Nordberg GF, Fowler BA, Nordberg M, Friberg LT, editors. Handbook on the toxicology of metals. 3rd ed. London: Academic Press; 2008.

21.

Vyas N, Yiannakis D, Turner A, Sewell GJ. Occupational exposure to anti-cancer drugs: a review of effects of new technology. J Oncol Pharm Pract. 2014;20(4):278–87. https://doi.org/10.1177/1078155213498630.CrossRefPubMed

22.

Simon N, Vasseur M, Pinturaud M, Soichot M, Richeval C, Humbert L, Lebecque M, Sidikou O, Barthelemy C, Bonnabry P, Allorge D, Decaudin B, Odou P. Effectiveness of a Closed-System Transfer Device in Reducing Surface Contamination in a New Antineoplastic Drug-Compounding Unit: A Prospective, Controlled, Parallel Study. PLoS One. 2016;11(7):e0159052. https://doi.org/10.1371/journal.pone.0159052.CrossRefPubMedPubMedCentral

23.

Graham MA, Lockwood GF, Greenslade D, Brienza S, Bayssas M, Gamelin E. Clinical pharmacokinetics of oxaliplatin: a critical review. Clin Cancer Res. 2000;6(4):1205–18.PubMed

24.

Easty AC, Coakley N, Cheng R, Cividino M, Savage P, Tozer R, White RE. Safe handling of cytotoxics: guideline recommendations. Curr Oncol. 2015;22(1):e27–37. https://doi.org/10.3747/co.21.2151.CrossRefPubMedPubMedCentral

Title: Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital
Authors: Ai Hori
Mari Shimura
Yutaka Iida
Kazuhiko Yamada
Kyoko Nohara
Takayuki Ichinose
Ai Yamashita
Junko Shirataki
Shotaro Hagiwara
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: Journal of Occupational Medicine and Toxicology / Issue 1/2020
Electronic ISSN: 1745-6673
DOI: https://doi.org/10.1186/s12995-020-00280-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Occupational exposure of platinum-based anti-cancer drugs: five-year monitoring of hair and environmental samples in a single hospital

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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