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Published in: Acta Neurochirurgica 2/2017

01-02-2017 | Case Report - Neurosurgery Training

Occipital lobe gumma: a case report and review of the literature

Authors: Konstantinos Faropoulos, Vassiliki Zolota, George Gatzounis

Published in: Acta Neurochirurgica | Issue 2/2017

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Abstract

Syphilis has plagued humanity for thousands of years. Despite the measures of precaution against its transmission and the advancement of modern pharmacology, late-stage phenomena like intracerebral gumma are not uncommon even today. We present a complex case, which has misled the physicians twice. Additionally, we performed a review of the contemporary literature about the common location, clinical findings and up-to-date treatment of intracerebral gummas.
Literature
1.
go back to reference Agrons GA, Han SS, Husson MA, Simeone F (1991) MR imaging of cerebral gumma. AJNR Am J Neuroradiol 12:80–81PubMed Agrons GA, Han SS, Husson MA, Simeone F (1991) MR imaging of cerebral gumma. AJNR Am J Neuroradiol 12:80–81PubMed
2.
go back to reference Ances BM, Danish SF, Kolson DL, Judy KD, Liebeskind DS (2005) Cerebral gumma mimicking glioblastoma multiforme. Neurocrit Care 2:300–302CrossRefPubMed Ances BM, Danish SF, Kolson DL, Judy KD, Liebeskind DS (2005) Cerebral gumma mimicking glioblastoma multiforme. Neurocrit Care 2:300–302CrossRefPubMed
3.
go back to reference Berger JR, Waskin H, Pall L, Hensley G, Ihmedian I, Post MJ (1992) Syphilitic cerebral gumma with HIV infection. Neurology 42:1282–1287CrossRefPubMed Berger JR, Waskin H, Pall L, Hensley G, Ihmedian I, Post MJ (1992) Syphilitic cerebral gumma with HIV infection. Neurology 42:1282–1287CrossRefPubMed
4.
go back to reference Darwish BS, Fowler AM, Swaminothan A, Abraszko R (2008) Intracranial syphilitic gumma resembling malignant brain tumour. J Clin Neurosci 15(3):308–310CrossRefPubMed Darwish BS, Fowler AM, Swaminothan A, Abraszko R (2008) Intracranial syphilitic gumma resembling malignant brain tumour. J Clin Neurosci 15(3):308–310CrossRefPubMed
5.
6.
go back to reference Fargen KM, Alvernia JE, Lin CS, Melgar M (2009) Cerebral syphilitic gummata: a case presentation and analysis of 156 reported cases. Neurosurgery 64(3):568–575CrossRefPubMed Fargen KM, Alvernia JE, Lin CS, Melgar M (2009) Cerebral syphilitic gummata: a case presentation and analysis of 156 reported cases. Neurosurgery 64(3):568–575CrossRefPubMed
7.
go back to reference Fleet WS, Watson RT, Ballinger WE (1986) Resolution of a gumma with steroid therapy. Neurology 36:1104–1107CrossRefPubMed Fleet WS, Watson RT, Ballinger WE (1986) Resolution of a gumma with steroid therapy. Neurology 36:1104–1107CrossRefPubMed
8.
go back to reference Herrold JM (1994) A syphilitic cerebral gumma manifesting as brain-stem mass that responded to corticosteroid monotherapy. Mayo Clin Proc 69:960–961CrossRefPubMed Herrold JM (1994) A syphilitic cerebral gumma manifesting as brain-stem mass that responded to corticosteroid monotherapy. Mayo Clin Proc 69:960–961CrossRefPubMed
9.
go back to reference Horowitz H, Valsamis MP, Wicher V, Abbruscato F, Larsen SA, Wormser GP, Wicher K (1994) Cerebral syphilitic gumma confirmed by the polymerase chain reaction in a man with human immunodeficiency virus infection. N Engl J Med 331:1488–1491CrossRefPubMed Horowitz H, Valsamis MP, Wicher V, Abbruscato F, Larsen SA, Wormser GP, Wicher K (1994) Cerebral syphilitic gumma confirmed by the polymerase chain reaction in a man with human immunodeficiency virus infection. N Engl J Med 331:1488–1491CrossRefPubMed
10.
go back to reference Inoue R, Katayama S, Kusakabe T, Mori T, Hori S (1995) Cerebral gumma showing linear dural enhancement on magnetic resonance imaging. Neurol Med Chir 35:813–817CrossRef Inoue R, Katayama S, Kusakabe T, Mori T, Hori S (1995) Cerebral gumma showing linear dural enhancement on magnetic resonance imaging. Neurol Med Chir 35:813–817CrossRef
11.
go back to reference Ito M, Sato K, Tada H, Kuru Y (1990) Neurosyphilis manifesting as a focal mass lesion: computed tomographic and magnetic resonance imaging features—case report. Neurol Med Chir (Tokyo) 30(3):194–197CrossRef Ito M, Sato K, Tada H, Kuru Y (1990) Neurosyphilis manifesting as a focal mass lesion: computed tomographic and magnetic resonance imaging features—case report. Neurol Med Chir (Tokyo) 30(3):194–197CrossRef
12.
go back to reference Kaplan JG, Sterman AB, Horoupan D, Leeds NE, Zimmerman RD, Gade R (1981) Luetic meningitis with gumma: clinical, radiographic, and neuropathologic features. Neurology 31:464–467CrossRefPubMed Kaplan JG, Sterman AB, Horoupan D, Leeds NE, Zimmerman RD, Gade R (1981) Luetic meningitis with gumma: clinical, radiographic, and neuropathologic features. Neurology 31:464–467CrossRefPubMed
13.
go back to reference Larsen SA, Steiner BM, Rudolph AH (1995) Laboratory diagnosis and interpretation of tests for syphilis. Clin Microbiol Rev 8:1–21PubMedPubMedCentral Larsen SA, Steiner BM, Rudolph AH (1995) Laboratory diagnosis and interpretation of tests for syphilis. Clin Microbiol Rev 8:1–21PubMedPubMedCentral
14.
go back to reference Lee CW, Lim MJ, Son D, Lee JS, Cheong MH, Park IS, Lim MK, Kim E, Ha Y (2009) A case of cerebral gumma presenting as brain tumor in a human immunodeficiency virus (HIV)-negative patient. Yonsei Med J 50(2):284–288 Lee CW, Lim MJ, Son D, Lee JS, Cheong MH, Park IS, Lim MK, Kim E, Ha Y (2009) A case of cerebral gumma presenting as brain tumor in a human immunodeficiency virus (HIV)-negative patient. Yonsei Med J 50(2):284–288
15.
go back to reference Marra CM (2004) Infections of the central nervous system. Lippincott Williams and Wilkins, Philadelphia, pp 649–657 Marra CM (2004) Infections of the central nervous system. Lippincott Williams and Wilkins, Philadelphia, pp 649–657
16.
go back to reference Neuhaus O, Kieseier B, Hartung HP (2007) Immunosuppressive agents in multiple sclerosis. Neurotherapeutics 4(4):654-660 Neuhaus O, Kieseier B, Hartung HP (2007) Immunosuppressive agents in multiple sclerosis. Neurotherapeutics 4(4):654-660
17.
go back to reference Perini P, Calabrese M, Rinaldi L, Gallo P (2008) Cyclophosphamide-based combination therapies for autoimmunity. Neurol Sci 29(Suppl 2):S233–S234CrossRefPubMed Perini P, Calabrese M, Rinaldi L, Gallo P (2008) Cyclophosphamide-based combination therapies for autoimmunity. Neurol Sci 29(Suppl 2):S233–S234CrossRefPubMed
18.
go back to reference Pizarro A, Fonseca E, Anciones B, Lara L, Contreras F (1992) Long-term undiagnosed syphilis with clinical presentation of meningitis. Clin Exp Dermatol 17:125–126CrossRefPubMed Pizarro A, Fonseca E, Anciones B, Lara L, Contreras F (1992) Long-term undiagnosed syphilis with clinical presentation of meningitis. Clin Exp Dermatol 17:125–126CrossRefPubMed
19.
go back to reference Rinaldi L, Perini P, Calabrese M, Gallo P (2009) Cyclophosphamide as second-line therapy in multiple sclerosis: benefits and risks. Neurol Sci 30(Suppl 2):S171–S173CrossRefPubMed Rinaldi L, Perini P, Calabrese M, Gallo P (2009) Cyclophosphamide as second-line therapy in multiple sclerosis: benefits and risks. Neurol Sci 30(Suppl 2):S171–S173CrossRefPubMed
20.
go back to reference Roeske C, Kennedy PR (1996) Syphilitic gummas in a patient with human immunodeficiency virus infection. N Engl J Med 335:1123CrossRefPubMed Roeske C, Kennedy PR (1996) Syphilitic gummas in a patient with human immunodeficiency virus infection. N Engl J Med 335:1123CrossRefPubMed
21.
go back to reference Tien R, Gean-Marton AD, Mark AS (1992) Neurosyphilis in HIV carriers: MR findings in six patients. AJR Am J Roentgenol 158:1325-1328 Tien R, Gean-Marton AD, Mark AS (1992) Neurosyphilis in HIV carriers: MR findings in six patients. AJR Am J Roentgenol 158:1325-1328
22.
go back to reference Uemura K, Yamada T, Tsukada A, Enomoto T, Yoshii Y, Nose T (1995) Cerebral gumma mimicking glioblastoma on magnetic resonance images—case report. Neurol Med Chir (Tokyo) 35(7):462–466CrossRef Uemura K, Yamada T, Tsukada A, Enomoto T, Yoshii Y, Nose T (1995) Cerebral gumma mimicking glioblastoma on magnetic resonance images—case report. Neurol Med Chir (Tokyo) 35(7):462–466CrossRef
23.
go back to reference Vogl T, Dresel S, Lochmüller H, Bergman C, Reimers C, Lissner J (1993) Third cranial nerve palsy caused by gummatous neurosyphilis: MR findings. AJNR Am J Neuroradiol 14:1329–1331PubMed Vogl T, Dresel S, Lochmüller H, Bergman C, Reimers C, Lissner J (1993) Third cranial nerve palsy caused by gummatous neurosyphilis: MR findings. AJNR Am J Neuroradiol 14:1329–1331PubMed
Metadata
Title
Occipital lobe gumma: a case report and review of the literature
Authors
Konstantinos Faropoulos
Vassiliki Zolota
George Gatzounis
Publication date
01-02-2017
Publisher
Springer Vienna
Published in
Acta Neurochirurgica / Issue 2/2017
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI
https://doi.org/10.1007/s00701-016-3015-x

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