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Published in: Current Psychiatry Reports 5/2012

01-10-2012 | Sleep Disorders (MJ Sateia, Section Editor)

Obstructive Sleep Apnea and Severe Mental Illness: Evolution and Consequences

Authors: Wei-Chen Lin, John W. Winkelman

Published in: Current Psychiatry Reports | Issue 5/2012

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Abstract

Sleep complaints are commonly encountered in psychiatric clinics. Underlying medical disorders or sleep disorders need to be identified and treated to optimize treatment of the mental illness. Excessive daytime sleepiness, which is the main symptom of obstructive sleep apnea (OSA), overlaps with those of many severe mental illnesses. Medication side effects or the disorder itself maybe account for daytime sleepiness but comorbid OSA is a possibility that should not be overlooked. The diagnosis of OSA is straightforward but treatment compliance is problematic in psychiatric patients. This article summarizes studies concerning comorbid OSA in patients with severe mental illness and includes suggestions for future investigations.
Literature
1.
go back to reference Gibson GJ. Obstructive sleep apnoea syndrome: underestimated and undertreated. Br Med Bull. 2004;72:49–65.PubMedCrossRef Gibson GJ. Obstructive sleep apnoea syndrome: underestimated and undertreated. Br Med Bull. 2004;72:49–65.PubMedCrossRef
2.
go back to reference Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165:1217–39.PubMedCrossRef Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med. 2002;165:1217–39.PubMedCrossRef
3.
4.
go back to reference Jenkinson C, Stradling J, Petersen S. Comparison of three measures of quality of life outcome in the evaluation of continuous positive airways pressure therapy for sleep apnoea. J Sleep Res. 1997;6:199–204.PubMedCrossRef Jenkinson C, Stradling J, Petersen S. Comparison of three measures of quality of life outcome in the evaluation of continuous positive airways pressure therapy for sleep apnoea. J Sleep Res. 1997;6:199–204.PubMedCrossRef
5.
go back to reference George CF, Nickerson PW, Hanly PJ, Millar TW, Kryger MH. Sleep apnoea patients have more automobile accidents. Lancet. 1987;2:447.PubMedCrossRef George CF, Nickerson PW, Hanly PJ, Millar TW, Kryger MH. Sleep apnoea patients have more automobile accidents. Lancet. 1987;2:447.PubMedCrossRef
6.
go back to reference Suzuki M, Otsuka K, Guilleminault C. Long-term nasal continuous positive airway pressure administration can normalize hypertension in obstructive sleep apnea patients. Sleep. 1993;16:545–9.PubMed Suzuki M, Otsuka K, Guilleminault C. Long-term nasal continuous positive airway pressure administration can normalize hypertension in obstructive sleep apnea patients. Sleep. 1993;16:545–9.PubMed
7.
go back to reference Gotsopoulos H, Chen C, Qian J, Cistulli PA. Oral appliance therapy improves symptoms in obstructive sleep apnea: a randomized, controlled trial. Am J Respir Crit Care Med. 2002;166:743–8.PubMedCrossRef Gotsopoulos H, Chen C, Qian J, Cistulli PA. Oral appliance therapy improves symptoms in obstructive sleep apnea: a randomized, controlled trial. Am J Respir Crit Care Med. 2002;166:743–8.PubMedCrossRef
8.
go back to reference Newcomer JW, Hennekens CH. Severe mental illness and risk of cardiovascular disease. JAMA. 2007;298:1794–6.PubMedCrossRef Newcomer JW, Hennekens CH. Severe mental illness and risk of cardiovascular disease. JAMA. 2007;298:1794–6.PubMedCrossRef
9.
go back to reference Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry. 2007;64:1123–31.PubMedCrossRef Saha S, Chant D, McGrath J. A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time? Arch Gen Psychiatry. 2007;64:1123–31.PubMedCrossRef
10.
go back to reference Sharafkhaneh A, Giray N, Richardson P, Young T, Hirshkowitz M. Association of psychiatric disorders and sleep apnea in a large cohort. Sleep. 2005;28:1405–11.PubMed Sharafkhaneh A, Giray N, Richardson P, Young T, Hirshkowitz M. Association of psychiatric disorders and sleep apnea in a large cohort. Sleep. 2005;28:1405–11.PubMed
11.
go back to reference Andrews JG, Oei TP. The roles of depression and anxiety in the understanding and treatment of obstructive sleep apnea syndrome. Clin Psychol Rev. 2004;24:1031–49.PubMedCrossRef Andrews JG, Oei TP. The roles of depression and anxiety in the understanding and treatment of obstructive sleep apnea syndrome. Clin Psychol Rev. 2004;24:1031–49.PubMedCrossRef
12.
go back to reference Saunamaki T, Jehkonen M. Depression and anxiety in obstructive sleep apnea syndrome: a review. Acta Neurol Scand. 2007;116:277–88.PubMedCrossRef Saunamaki T, Jehkonen M. Depression and anxiety in obstructive sleep apnea syndrome: a review. Acta Neurol Scand. 2007;116:277–88.PubMedCrossRef
13.
go back to reference Ohayon MM. The effects of breathing-related sleep disorders on mood disturbances in the general population. J Clin Psychiatry. 2003;64:1195–200. quiz, 274–6.PubMedCrossRef Ohayon MM. The effects of breathing-related sleep disorders on mood disturbances in the general population. J Clin Psychiatry. 2003;64:1195–200. quiz, 274–6.PubMedCrossRef
14.
go back to reference • Wheaton AG, Perry GS, Chapman DP, Croft JB. Sleep Disordered Breathing and Depression among U.S. Adults: National Health and Nutrition Examination Survey, 2005–2008. Sleep. 2012;35:461–7. This national study found that sleep disordered breathing may be associated with probable major depression..PubMed • Wheaton AG, Perry GS, Chapman DP, Croft JB. Sleep Disordered Breathing and Depression among U.S. Adults: National Health and Nutrition Examination Survey, 2005–2008. Sleep. 2012;35:461–7. This national study found that sleep disordered breathing may be associated with probable major depression..PubMed
15.
go back to reference Pillar G, Lavie P. Psychiatric symptoms in sleep apnea syndrome: effects of gender and respiratory disturbance index. Chest. 1998;114:697–703.PubMedCrossRef Pillar G, Lavie P. Psychiatric symptoms in sleep apnea syndrome: effects of gender and respiratory disturbance index. Chest. 1998;114:697–703.PubMedCrossRef
16.
go back to reference Lee S. Depression in sleep apnea: a different view. J Clin Psychiatry. 1990;51:309–10.PubMed Lee S. Depression in sleep apnea: a different view. J Clin Psychiatry. 1990;51:309–10.PubMed
17.
go back to reference Gall R, Isaac L, Kryger M. Quality of life in mild obstructive sleep apnea. Sleep. 1993;16(8 Suppl):S59–61.PubMed Gall R, Isaac L, Kryger M. Quality of life in mild obstructive sleep apnea. Sleep. 1993;16(8 Suppl):S59–61.PubMed
18.
go back to reference Peppard PE, Szklo-Coxe M, Hla KM, Young T. Longitudinal association of sleep-related breathing disorder and depression. Arch Intern Med. 2006;166:1709–15.PubMedCrossRef Peppard PE, Szklo-Coxe M, Hla KM, Young T. Longitudinal association of sleep-related breathing disorder and depression. Arch Intern Med. 2006;166:1709–15.PubMedCrossRef
19.
go back to reference Bardwell WA, Berry CC, Ancoli-Israel S, Dimsdale JE. Psychological correlates of sleep apnea. J Psychosom Res. 1999;47:583–96.PubMedCrossRef Bardwell WA, Berry CC, Ancoli-Israel S, Dimsdale JE. Psychological correlates of sleep apnea. J Psychosom Res. 1999;47:583–96.PubMedCrossRef
20.
go back to reference Bardwell WA, Moore P, Ancoli-Israel S, Dimsdale JE. Fatigue in obstructive sleep apnea: driven by depressive symptoms instead of apnea severity? Am J Psychiatry. 2003;160:350–5.PubMedCrossRef Bardwell WA, Moore P, Ancoli-Israel S, Dimsdale JE. Fatigue in obstructive sleep apnea: driven by depressive symptoms instead of apnea severity? Am J Psychiatry. 2003;160:350–5.PubMedCrossRef
21.
go back to reference Caples SM, Gami AS, Somers VK. Obstructive sleep apnea. Ann Intern Med. 2005;142:187–97.PubMed Caples SM, Gami AS, Somers VK. Obstructive sleep apnea. Ann Intern Med. 2005;142:187–97.PubMed
22.
go back to reference Edinger JD, Carwile S, Miller P, Hope V, Mayti C. Psychological status, syndromatic measures, and compliance with nasal CPAP therapy for sleep apnea. Percept Mot Skills. 1994;78(3 Pt 2):1116–8.PubMedCrossRef Edinger JD, Carwile S, Miller P, Hope V, Mayti C. Psychological status, syndromatic measures, and compliance with nasal CPAP therapy for sleep apnea. Percept Mot Skills. 1994;78(3 Pt 2):1116–8.PubMedCrossRef
23.
go back to reference Krahn LE, Miller BW, Bergstrom LR. Rapid resolution of intense suicidal ideation after treatment of severe obstructive sleep apnea. J Clin Sleep Med. 2008;4:64–5.PubMed Krahn LE, Miller BW, Bergstrom LR. Rapid resolution of intense suicidal ideation after treatment of severe obstructive sleep apnea. J Clin Sleep Med. 2008;4:64–5.PubMed
24.
go back to reference Millman RP, Fogel BS, McNamara ME, Carlisle CC. Depression as a manifestation of obstructive sleep apnea: reversal with nasal continuous positive airway pressure. J Clin Psychiatry. 1989;50:348–51.PubMed Millman RP, Fogel BS, McNamara ME, Carlisle CC. Depression as a manifestation of obstructive sleep apnea: reversal with nasal continuous positive airway pressure. J Clin Psychiatry. 1989;50:348–51.PubMed
25.
go back to reference Berger AJ, Bayliss DA, Viana F. Modulation of neonatal rat hypoglossal motoneuron excitability by serotonin. Neurosci Lett. 1992;143:164–8.PubMedCrossRef Berger AJ, Bayliss DA, Viana F. Modulation of neonatal rat hypoglossal motoneuron excitability by serotonin. Neurosci Lett. 1992;143:164–8.PubMedCrossRef
26.
go back to reference Fenik P, Veasey SC. Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus. Am J Respir Crit Care Med. 2003;167:563–9.PubMedCrossRef Fenik P, Veasey SC. Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus. Am J Respir Crit Care Med. 2003;167:563–9.PubMedCrossRef
27.
go back to reference Veasey SC. Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential. Am J Respir Med. 2003;2:21–9.PubMedCrossRef Veasey SC. Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential. Am J Respir Med. 2003;2:21–9.PubMedCrossRef
28.
go back to reference • Marshall NS, Yee BJ, Desai AV, Buchanan PR, Wong KK, Crompton R, et al. Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. Sleep. 2008;31:824–31. This study found that mirtazapine has limited benefit for treatment of OSA.PubMed • Marshall NS, Yee BJ, Desai AV, Buchanan PR, Wong KK, Crompton R, et al. Two randomized placebo-controlled trials to evaluate the efficacy and tolerability of mirtazapine for the treatment of obstructive sleep apnea. Sleep. 2008;31:824–31. This study found that mirtazapine has limited benefit for treatment of OSA.PubMed
29.
go back to reference Kaplan R. Obstructive sleep apnoea and depression–diagnostic and treatment implications. Aust N Z J Psychiatry. 1992;26:586–91.PubMedCrossRef Kaplan R. Obstructive sleep apnoea and depression–diagnostic and treatment implications. Aust N Z J Psychiatry. 1992;26:586–91.PubMedCrossRef
30.
go back to reference Farney RJ, Lugo A, Jensen RL, Walker JM, Cloward TV. Simultaneous use of antidepressant and antihypertensive medications increases likelihood of diagnosis of obstructive sleep apnea syndrome. Chest. 2004;125:1279–85.PubMedCrossRef Farney RJ, Lugo A, Jensen RL, Walker JM, Cloward TV. Simultaneous use of antidepressant and antihypertensive medications increases likelihood of diagnosis of obstructive sleep apnea syndrome. Chest. 2004;125:1279–85.PubMedCrossRef
31.
go back to reference Munoz A, Mayoralas LR, Barbe F, Pericas J, Agusti AG. Long-term effects of CPAP on daytime functioning in patients with sleep apnoea syndrome. Eur Respir J. 2000;15:676–81.PubMedCrossRef Munoz A, Mayoralas LR, Barbe F, Pericas J, Agusti AG. Long-term effects of CPAP on daytime functioning in patients with sleep apnoea syndrome. Eur Respir J. 2000;15:676–81.PubMedCrossRef
32.
go back to reference Asghari A, Mohammadi F, Kamrava SK, Tavakoli S, Farhadi M. Severity of depression and anxiety in obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. 2012. Asghari A, Mohammadi F, Kamrava SK, Tavakoli S, Farhadi M. Severity of depression and anxiety in obstructive sleep apnea syndrome. Eur Arch Otorhinolaryngol. 2012.
33.
go back to reference Franco CM, Lima AM, Ataide L, Jr., Lins OG, Castro CM, Bezerra AA, et al. Obstructive sleep apnea severity correlates with cellular and plasma oxidative stress parameters and affective symptoms. J Mol Neurosci. 2012. Franco CM, Lima AM, Ataide L, Jr., Lins OG, Castro CM, Bezerra AA, et al. Obstructive sleep apnea severity correlates with cellular and plasma oxidative stress parameters and affective symptoms. J Mol Neurosci. 2012.
34.
go back to reference Einvik G, Hrubos-Strom H, Randby A, Nordhus IH, Somers VK, Omland T, et al. Major depressive disorder, anxiety disorders, and cardiac biomarkers in subjects at high risk of obstructive sleep apnea. Psychosom Med. 2011;73:378–84.PubMedCrossRef Einvik G, Hrubos-Strom H, Randby A, Nordhus IH, Somers VK, Omland T, et al. Major depressive disorder, anxiety disorders, and cardiac biomarkers in subjects at high risk of obstructive sleep apnea. Psychosom Med. 2011;73:378–84.PubMedCrossRef
35.
go back to reference Kjelsberg FN, Ruud EA, Stavem K. Predictors of symptoms of anxiety and depression in obstructive sleep apnea. Sleep Med. 2005;6:341–6.PubMedCrossRef Kjelsberg FN, Ruud EA, Stavem K. Predictors of symptoms of anxiety and depression in obstructive sleep apnea. Sleep Med. 2005;6:341–6.PubMedCrossRef
36.
go back to reference Chasens ER, Pack AI, Maislin G, Dinges DF, Weaver TE. Claustrophobia and adherence to CPAP treatment. West J Nurs Res. 2005;27:307–21.PubMedCrossRef Chasens ER, Pack AI, Maislin G, Dinges DF, Weaver TE. Claustrophobia and adherence to CPAP treatment. West J Nurs Res. 2005;27:307–21.PubMedCrossRef
37.
go back to reference Yang CM, Liao YS, Lin CM, Chou SL, Wang EN. Psychological and behavioral factors in patients with comorbid obstructive sleep apnea and insomnia. J Psychosom Res. 2011;70:355–61.PubMedCrossRef Yang CM, Liao YS, Lin CM, Chou SL, Wang EN. Psychological and behavioral factors in patients with comorbid obstructive sleep apnea and insomnia. J Psychosom Res. 2011;70:355–61.PubMedCrossRef
38.
go back to reference Berge D, Salgado P, Rodriguez A, Bulbena A. Onset of mania after CPAP in a man with obstructive sleep apnea. Psychosomatics. 2008;49:447–9.PubMedCrossRef Berge D, Salgado P, Rodriguez A, Bulbena A. Onset of mania after CPAP in a man with obstructive sleep apnea. Psychosomatics. 2008;49:447–9.PubMedCrossRef
39.
go back to reference Hilleret H, Jeunet E, Osiek C, Mohr S, Blois R, Bertschy G. Mania resulting from continuous positive airways pressure in a depressed man with sleep apnea syndrome. Neuropsychobiology. 2001;43:221–4.PubMedCrossRef Hilleret H, Jeunet E, Osiek C, Mohr S, Blois R, Bertschy G. Mania resulting from continuous positive airways pressure in a depressed man with sleep apnea syndrome. Neuropsychobiology. 2001;43:221–4.PubMedCrossRef
40.
go back to reference • Plante DT, Winkelman JW. Sleep disturbance in bipolar disorder: therapeutic implications. Am J Psychiatry. 2008;165:830–43. This is a thorough review about bipolar disorder and sleep disorders..PubMedCrossRef • Plante DT, Winkelman JW. Sleep disturbance in bipolar disorder: therapeutic implications. Am J Psychiatry. 2008;165:830–43. This is a thorough review about bipolar disorder and sleep disorders..PubMedCrossRef
41.
go back to reference Bastiampillai T, Khor LJ, Dhillon R. Complicated management of mania in the setting of undiagnosed obstructive sleep apnea. J ECT. 2011;27:e15–6.PubMedCrossRef Bastiampillai T, Khor LJ, Dhillon R. Complicated management of mania in the setting of undiagnosed obstructive sleep apnea. J ECT. 2011;27:e15–6.PubMedCrossRef
42.
go back to reference Winkelman JW. Schizophrenia, obesity, and obstructive sleep apnea. J Clin Psychiatry. 2001;62:8–11.PubMedCrossRef Winkelman JW. Schizophrenia, obesity, and obstructive sleep apnea. J Clin Psychiatry. 2001;62:8–11.PubMedCrossRef
43.
go back to reference Ancoli-Israel S, Martin J, Jones DW, Caligiuri M, Patterson T, Harris MJ, et al. Sleep-disordered breathing and periodic limb movements in sleep in older patients with schizophrenia. Biol Psychiatry. 1999;45:1426–32.PubMedCrossRef Ancoli-Israel S, Martin J, Jones DW, Caligiuri M, Patterson T, Harris MJ, et al. Sleep-disordered breathing and periodic limb movements in sleep in older patients with schizophrenia. Biol Psychiatry. 1999;45:1426–32.PubMedCrossRef
44.
go back to reference Takahashi KI, Shimizu T, Sugita T, Saito Y, Takahashi Y, Hishikawa Y. Prevalence of sleep-related respiratory disorders in 101 schizophrenic inpatients. Psychiatry Clin Neurosci. 1998;52:229–31.PubMedCrossRef Takahashi KI, Shimizu T, Sugita T, Saito Y, Takahashi Y, Hishikawa Y. Prevalence of sleep-related respiratory disorders in 101 schizophrenic inpatients. Psychiatry Clin Neurosci. 1998;52:229–31.PubMedCrossRef
45.
go back to reference Bai YM, Lin CC, Chen JY, Chen TT, Su TP, Chou P. Association of weight gain and metabolic syndrome in patients taking clozapine: an 8-year cohort study. J Clin Psychiatry. 2011;72:751–6.PubMedCrossRef Bai YM, Lin CC, Chen JY, Chen TT, Su TP, Chou P. Association of weight gain and metabolic syndrome in patients taking clozapine: an 8-year cohort study. J Clin Psychiatry. 2011;72:751–6.PubMedCrossRef
46.
go back to reference • Hall MH, Okun ML, Sowers M, Matthews KA, Kravitz HM, Hardin K, et al. Sleep is associated with the metabolic syndrome in a multi-ethnic cohort of midlife women: The SWAN Sleep Study. Sleep. 2012;35:783–90. This cohort study found that sleep disordered breathing is associated with metabolic syndrome in women..PubMed • Hall MH, Okun ML, Sowers M, Matthews KA, Kravitz HM, Hardin K, et al. Sleep is associated with the metabolic syndrome in a multi-ethnic cohort of midlife women: The SWAN Sleep Study. Sleep. 2012;35:783–90. This cohort study found that sleep disordered breathing is associated with metabolic syndrome in women..PubMed
47.
go back to reference Sugishita K, Yamasue H, Kasai K. Continuous positive airway pressure for obstructive sleep apnea improved negative symptoms in a patient with schizophrenia. Psychiatry Clin Neurosci. 2010;64:665.PubMedCrossRef Sugishita K, Yamasue H, Kasai K. Continuous positive airway pressure for obstructive sleep apnea improved negative symptoms in a patient with schizophrenia. Psychiatry Clin Neurosci. 2010;64:665.PubMedCrossRef
48.
go back to reference Strakowski SM, Hudson JI, Keck Jr PE, Wilson DR, Frankenburg FR, Alpert JE, et al. Four cases of obstructive sleep apnea associated with treatment-resistant mania. J Clin Psychiatry. 1991;52:156–8.PubMed Strakowski SM, Hudson JI, Keck Jr PE, Wilson DR, Frankenburg FR, Alpert JE, et al. Four cases of obstructive sleep apnea associated with treatment-resistant mania. J Clin Psychiatry. 1991;52:156–8.PubMed
49.
go back to reference Cunningham SL, Ellsworth SD, Winkelman JW, Dorsey CM, Ford AR, Lukas SE. Compliance with nasal continuous positive airway pressure in psychiatric patients with obstructive sleep apnea. Sleep Res. 1994;23:192. Cunningham SL, Ellsworth SD, Winkelman JW, Dorsey CM, Ford AR, Lukas SE. Compliance with nasal continuous positive airway pressure in psychiatric patients with obstructive sleep apnea. Sleep Res. 1994;23:192.
50.
go back to reference American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washinton, DC: American Psychiatric Press; 1994. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washinton, DC: American Psychiatric Press; 1994.
51.
go back to reference Ross RJ, Ball WA, Sullivan KA, Caroff SN. Sleep disturbance as the hallmark of posttraumatic stress disorder. Am J Psychiatry. 1989;146:697–707.PubMed Ross RJ, Ball WA, Sullivan KA, Caroff SN. Sleep disturbance as the hallmark of posttraumatic stress disorder. Am J Psychiatry. 1989;146:697–707.PubMed
52.
go back to reference Krakow B, Melendrez D, Pedersen B, Johnston L, Hollifield M, Germain A, et al. Complex insomnia: insomnia and sleep-disordered breathing in a consecutive series of crime victims with nightmares and PTSD. Biol Psychiatry. 2001;49:948–53.PubMedCrossRef Krakow B, Melendrez D, Pedersen B, Johnston L, Hollifield M, Germain A, et al. Complex insomnia: insomnia and sleep-disordered breathing in a consecutive series of crime victims with nightmares and PTSD. Biol Psychiatry. 2001;49:948–53.PubMedCrossRef
53.
go back to reference Krakow B, Haynes PL, Warner TD, Santana E, Melendrez D, Johnston L, et al. Nightmares, insomnia, and sleep-disordered breathing in fire evacuees seeking treatment for posttraumatic sleep disturbance. J Trauma Stress. 2004;17:257–68.PubMedCrossRef Krakow B, Haynes PL, Warner TD, Santana E, Melendrez D, Johnston L, et al. Nightmares, insomnia, and sleep-disordered breathing in fire evacuees seeking treatment for posttraumatic sleep disturbance. J Trauma Stress. 2004;17:257–68.PubMedCrossRef
54.
go back to reference • Yesavage JA, Kinoshita LM, Kimball T, Zeitzer J, Friedman L, Noda A, et al. Sleep-disordered breathing in Vietnam veterans with posttraumatic stress disorder. Am J Geriatr Psychiatry. 2012;20:199–204. This study found high prevalence of sleep breathing disorder in patients with PTSD..PubMedCrossRef • Yesavage JA, Kinoshita LM, Kimball T, Zeitzer J, Friedman L, Noda A, et al. Sleep-disordered breathing in Vietnam veterans with posttraumatic stress disorder. Am J Geriatr Psychiatry. 2012;20:199–204. This study found high prevalence of sleep breathing disorder in patients with PTSD..PubMedCrossRef
55.
go back to reference Krakow B, Melendrez D, Warner TD, Clark JO, Sisley BN, Dorin R, et al. Signs and symptoms of sleep-disordered breathing in trauma survivors: a matched comparison with classic sleep apnea patients. J Nerv Ment Dis. 2006;194:433–9.PubMedCrossRef Krakow B, Melendrez D, Warner TD, Clark JO, Sisley BN, Dorin R, et al. Signs and symptoms of sleep-disordered breathing in trauma survivors: a matched comparison with classic sleep apnea patients. J Nerv Ment Dis. 2006;194:433–9.PubMedCrossRef
56.
go back to reference • Kinoshita LM, Yesavage JA, Noda A, Jo B, Hernandez B, Taylor J, et al. Modeling the effects of obstructive sleep apnea and hypertension in Vietnam veterans with PTSD. Sleep Breath. 2011. This study found that severity of OSA is correlated with poor cognitive function in PTSD patients. • Kinoshita LM, Yesavage JA, Noda A, Jo B, Hernandez B, Taylor J, et al. Modeling the effects of obstructive sleep apnea and hypertension in Vietnam veterans with PTSD. Sleep Breath. 2011. This study found that severity of OSA is correlated with poor cognitive function in PTSD patients.
57.
go back to reference Carrasco E, Santamaria J, Iranzo A, Pintor L, De Pablo J, Solanas A, et al. Changes in dreaming induced by CPAP in severe obstructive sleep apnea syndrome patients. J Sleep Res. 2006;15:430–6.PubMedCrossRef Carrasco E, Santamaria J, Iranzo A, Pintor L, De Pablo J, Solanas A, et al. Changes in dreaming induced by CPAP in severe obstructive sleep apnea syndrome patients. J Sleep Res. 2006;15:430–6.PubMedCrossRef
58.
go back to reference Guilleminault C, Kirisoglu C, Bao G, Arias V, Chan A, Li KK. Adult chronic sleepwalking and its treatment based on polysomnography. Brain. 2005;128(Pt 5):1062–9.PubMedCrossRef Guilleminault C, Kirisoglu C, Bao G, Arias V, Chan A, Li KK. Adult chronic sleepwalking and its treatment based on polysomnography. Brain. 2005;128(Pt 5):1062–9.PubMedCrossRef
59.
go back to reference Spoormaker VI, Montgomery P. Disturbed sleep in post-traumatic stress disorder: secondary symptom or core feature? Sleep Med Rev. 2008;12:169–84.PubMedCrossRef Spoormaker VI, Montgomery P. Disturbed sleep in post-traumatic stress disorder: secondary symptom or core feature? Sleep Med Rev. 2008;12:169–84.PubMedCrossRef
60.
go back to reference Krakow B, Lowry C, Germain A, Gaddy L, Hollifield M, Koss M, et al. A retrospective study on improvements in nightmares and post-traumatic stress disorder following treatment for comorbid sleep-disordered breathing. J Psychosom Res. 2000;49:291–8.PubMedCrossRef Krakow B, Lowry C, Germain A, Gaddy L, Hollifield M, Koss M, et al. A retrospective study on improvements in nightmares and post-traumatic stress disorder following treatment for comorbid sleep-disordered breathing. J Psychosom Res. 2000;49:291–8.PubMedCrossRef
61.
go back to reference El-Solh AA, Ayyar L, Akinnusi M, Relia S, Akinnusi O. Positive airway pressure adherence in veterans with posttraumatic stress disorder. Sleep. 2010;33:1495–500.PubMed El-Solh AA, Ayyar L, Akinnusi M, Relia S, Akinnusi O. Positive airway pressure adherence in veterans with posttraumatic stress disorder. Sleep. 2010;33:1495–500.PubMed
62.
go back to reference Sheehan DV, Ballenger J, Jacobsen G. Treatment of endogenous anxiety with phobic, hysterical, and hypochondriacal symptoms. Arch Gen Psychiatry. 1980;37:51–9.PubMedCrossRef Sheehan DV, Ballenger J, Jacobsen G. Treatment of endogenous anxiety with phobic, hysterical, and hypochondriacal symptoms. Arch Gen Psychiatry. 1980;37:51–9.PubMedCrossRef
63.
go back to reference Stein MB, Millar TW, Larsen DK, Kryger MH. Irregular breathing during sleep in patients with panic disorder. Am J Psychiatry. 1995;152:1168–73.PubMed Stein MB, Millar TW, Larsen DK, Kryger MH. Irregular breathing during sleep in patients with panic disorder. Am J Psychiatry. 1995;152:1168–73.PubMed
64.
go back to reference Hauri PJ, Friedman M, Ravaris CL. Sleep in patients with spontaneous panic attacks. Sleep. 1989;12:323–37.PubMed Hauri PJ, Friedman M, Ravaris CL. Sleep in patients with spontaneous panic attacks. Sleep. 1989;12:323–37.PubMed
65.
go back to reference Mellman TA, Uhde TW. Electroencephalographic sleep in panic disorder. A focus on sleep-related panic attacks. Arch Gen Psychiatry. 1989;46:178–84.PubMedCrossRef Mellman TA, Uhde TW. Electroencephalographic sleep in panic disorder. A focus on sleep-related panic attacks. Arch Gen Psychiatry. 1989;46:178–84.PubMedCrossRef
66.
go back to reference Lesser IM, Poland RE, Holcomb C, Rose DE. Electroencephalographic study of nighttime panic attacks. J Nerv Ment Dis. 1985;173:744–6.PubMedCrossRef Lesser IM, Poland RE, Holcomb C, Rose DE. Electroencephalographic study of nighttime panic attacks. J Nerv Ment Dis. 1985;173:744–6.PubMedCrossRef
67.
go back to reference Albert U, Maina G, Bergesio C, Bogetto F. Nocturnal panic and recent life events. Depress Anxiety. 2005;22:52–8.PubMedCrossRef Albert U, Maina G, Bergesio C, Bogetto F. Nocturnal panic and recent life events. Depress Anxiety. 2005;22:52–8.PubMedCrossRef
69.
go back to reference Mellman TA, Uhde TW. Sleep panic attacks: new clinical findings and theoretical implications. Am J Psychiatry. 1989;146:1204–7.PubMed Mellman TA, Uhde TW. Sleep panic attacks: new clinical findings and theoretical implications. Am J Psychiatry. 1989;146:1204–7.PubMed
70.
go back to reference Biber B, Alkin T. Panic disorder subtypes: differential responses to CO2 challenge. Am J Psychiatry. 1999;156:739–44.PubMed Biber B, Alkin T. Panic disorder subtypes: differential responses to CO2 challenge. Am J Psychiatry. 1999;156:739–44.PubMed
71.
go back to reference Sarisoy G, Boke O, Arik AC, Sahin AR. Panic disorder with nocturnal panic attacks: symptoms and comorbidities. Eur Psychiatry. 2008;23:195–200.PubMedCrossRef Sarisoy G, Boke O, Arik AC, Sahin AR. Panic disorder with nocturnal panic attacks: symptoms and comorbidities. Eur Psychiatry. 2008;23:195–200.PubMedCrossRef
72.
go back to reference Lopes FL, Nardi AE, Nascimento I, Valenca AM, Mezzasalma MA, Freire RC, et al. Diurnal panic attacks with and without nocturnal panic attacks: are there some phenomenological differences? Rev Bras Psiquiatr. 2005;27:216–21.PubMedCrossRef Lopes FL, Nardi AE, Nascimento I, Valenca AM, Mezzasalma MA, Freire RC, et al. Diurnal panic attacks with and without nocturnal panic attacks: are there some phenomenological differences? Rev Bras Psiquiatr. 2005;27:216–21.PubMedCrossRef
73.
go back to reference Freire RC, Valenca AM, Nascimento I, Lopes FL, Mezzasalma MA, Zin WA, et al. Clinical features of respiratory and nocturnal panic disorder subtypes. Psychiatry Res. 2007;152:287–91.PubMedCrossRef Freire RC, Valenca AM, Nascimento I, Lopes FL, Mezzasalma MA, Zin WA, et al. Clinical features of respiratory and nocturnal panic disorder subtypes. Psychiatry Res. 2007;152:287–91.PubMedCrossRef
74.
go back to reference Edlund MJ, McNamara ME, Millman RP. Sleep apnea and panic attacks. Compr Psychiatry. 1991;32:130–2.PubMedCrossRef Edlund MJ, McNamara ME, Millman RP. Sleep apnea and panic attacks. Compr Psychiatry. 1991;32:130–2.PubMedCrossRef
75.
go back to reference Alvarenga ME, Richards JC, Lambert G, Esler MD. Psychophysiological mechanisms in panic disorder: a correlative analysis of noradrenaline spillover, neuronal noradrenaline reuptake, power spectral analysis of heart rate variability, and psychological variables. Psychosom Med. 2006;68:8–16.PubMedCrossRef Alvarenga ME, Richards JC, Lambert G, Esler MD. Psychophysiological mechanisms in panic disorder: a correlative analysis of noradrenaline spillover, neuronal noradrenaline reuptake, power spectral analysis of heart rate variability, and psychological variables. Psychosom Med. 2006;68:8–16.PubMedCrossRef
76.
go back to reference Sullivan GM, Coplan JD, Kent JM, Gorman JM. The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias. Biol Psychiatry. 1999;46:1205–18.PubMedCrossRef Sullivan GM, Coplan JD, Kent JM, Gorman JM. The noradrenergic system in pathological anxiety: a focus on panic with relevance to generalized anxiety and phobias. Biol Psychiatry. 1999;46:1205–18.PubMedCrossRef
77.
go back to reference Sukegawa M, Noda A, Sugiura T, Nakata S, Yoshizaki S, Soga T, et al. Assessment of continuous positive airway pressure treatment in obstructive sleep apnea syndrome using 24-hour urinary catecholamines. Clin Cardiol. 2005;28:519–22.PubMedCrossRef Sukegawa M, Noda A, Sugiura T, Nakata S, Yoshizaki S, Soga T, et al. Assessment of continuous positive airway pressure treatment in obstructive sleep apnea syndrome using 24-hour urinary catecholamines. Clin Cardiol. 2005;28:519–22.PubMedCrossRef
78.
go back to reference • Takaesu Y, Inoue Y, Komada Y, Kagimura T, Iimori M. Effects of nasal continuous positive airway pressure on panic disorder comorbid with obstructive sleep apnea syndrome. Sleep Med. 2012;13:156–60. This study found treatment with CPAP may reduce panic symtoms in patients with comorbid panic disorder and OSA. PubMedCrossRef • Takaesu Y, Inoue Y, Komada Y, Kagimura T, Iimori M. Effects of nasal continuous positive airway pressure on panic disorder comorbid with obstructive sleep apnea syndrome. Sleep Med. 2012;13:156–60. This study found treatment with CPAP may reduce panic symtoms in patients with comorbid panic disorder and OSA. PubMedCrossRef
79.
go back to reference Roth T, Jaeger S, Jin R, Kalsekar A, Stang PE, Kessler RC. Sleep problems, comorbid mental disorders, and role functioning in the national comorbidity survey replication. Biol Psychiatry. 2006;60:1364–71.PubMedCrossRef Roth T, Jaeger S, Jin R, Kalsekar A, Stang PE, Kessler RC. Sleep problems, comorbid mental disorders, and role functioning in the national comorbidity survey replication. Biol Psychiatry. 2006;60:1364–71.PubMedCrossRef
80.
go back to reference Fakier N, Wild LG. Associations among sleep problems, learning difficulties and substance use in adolescence. J Adolesc. 2011;34:717–26.PubMedCrossRef Fakier N, Wild LG. Associations among sleep problems, learning difficulties and substance use in adolescence. J Adolesc. 2011;34:717–26.PubMedCrossRef
81.
go back to reference James JE, Kristjansson AL, Sigfusdottir ID. Adolescent substance use, sleep, and academic achievement: evidence of harm due to caffeine. J Adolesc. 2011;34:665–73.PubMedCrossRef James JE, Kristjansson AL, Sigfusdottir ID. Adolescent substance use, sleep, and academic achievement: evidence of harm due to caffeine. J Adolesc. 2011;34:665–73.PubMedCrossRef
83.
go back to reference Mahfoud Y, Talih F, Streem D, Budur K. Sleep disorders in substance abusers: how common are they? Psychiatry (Edgmont). 2009;6:38–42. Mahfoud Y, Talih F, Streem D, Budur K. Sleep disorders in substance abusers: how common are they? Psychiatry (Edgmont). 2009;6:38–42.
84.
go back to reference Brower KJ, Hall JM. Effects of age and alcoholism on sleep: a controlled study. J Stud Alcohol. 2001;62:335–43.PubMed Brower KJ, Hall JM. Effects of age and alcoholism on sleep: a controlled study. J Stud Alcohol. 2001;62:335–43.PubMed
85.
go back to reference Weissman MM, Greenwald S, Nino-Murcia G, Dement WC. The morbidity of insomnia uncomplicated by psychiatric disorders. Gen Hosp Psychiatry. 1997;19:245–50.PubMedCrossRef Weissman MM, Greenwald S, Nino-Murcia G, Dement WC. The morbidity of insomnia uncomplicated by psychiatric disorders. Gen Hosp Psychiatry. 1997;19:245–50.PubMedCrossRef
86.
go back to reference Drummond SP, Gillin JC, Smith TL, DeModena A. The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse. Alcohol Clin Exp Res. 1998;22:1796–802.PubMed Drummond SP, Gillin JC, Smith TL, DeModena A. The sleep of abstinent pure primary alcoholic patients: natural course and relationship to relapse. Alcohol Clin Exp Res. 1998;22:1796–802.PubMed
87.
go back to reference Le Bon O, Verbanck P, Hoffmann G, Murphy JR, Staner L, De Groote D, et al. Sleep in detoxified alcoholics: impairment of most standard sleep parameters and increased risk for sleep apnea, but not for myoclonias–a controlled study. J Stud Alcohol. 1997;58:30–6.PubMed Le Bon O, Verbanck P, Hoffmann G, Murphy JR, Staner L, De Groote D, et al. Sleep in detoxified alcoholics: impairment of most standard sleep parameters and increased risk for sleep apnea, but not for myoclonias–a controlled study. J Stud Alcohol. 1997;58:30–6.PubMed
88.
go back to reference Vitiello MV, Prinz PN, Personius JP, Vitaliano PP, Nuccio MA, Koerker R. Relationship of alcohol abuse history to nighttime hypoxemia in abstaining chronic alcoholic men. J Stud Alcohol. 1990;51:29–33.PubMed Vitiello MV, Prinz PN, Personius JP, Vitaliano PP, Nuccio MA, Koerker R. Relationship of alcohol abuse history to nighttime hypoxemia in abstaining chronic alcoholic men. J Stud Alcohol. 1990;51:29–33.PubMed
89.
go back to reference Issa FG, Sullivan CE. Alcohol, snoring and sleep apnea. J Neurol Neurosurg Psychiatry. 1982;45:353–9.PubMedCrossRef Issa FG, Sullivan CE. Alcohol, snoring and sleep apnea. J Neurol Neurosurg Psychiatry. 1982;45:353–9.PubMedCrossRef
90.
go back to reference • Vakulin A, Baulk SD, Catcheside PG, Antic NA, van den Heuvel CJ, Dorrian J, et al. Effects of alcohol and sleep restriction on simulated driving performance in untreated patients with obstructive sleep apnea. Ann Intern Med. 2009;151:447–55. This study found that patients with OSA have poorer driving performance than normal people under effects of alcohol and sleep restriction.PubMed • Vakulin A, Baulk SD, Catcheside PG, Antic NA, van den Heuvel CJ, Dorrian J, et al. Effects of alcohol and sleep restriction on simulated driving performance in untreated patients with obstructive sleep apnea. Ann Intern Med. 2009;151:447–55. This study found that patients with OSA have poorer driving performance than normal people under effects of alcohol and sleep restriction.PubMed
91.
go back to reference Effective medical treatment of opiate addiction. National Consensus Development Panel on Effective Medical Treatment of Opiate Addiction. JAMA. 1998;280(22):1936–43. Effective medical treatment of opiate addiction. National Consensus Development Panel on Effective Medical Treatment of Opiate Addiction. JAMA. 1998;280(22):1936–43.
92.
go back to reference Teichtahl H, Wang D, Cunnington D, Quinnell T, Tran H, Kronborg I, et al. Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients. Chest. 2005;128:1339–47.PubMedCrossRef Teichtahl H, Wang D, Cunnington D, Quinnell T, Tran H, Kronborg I, et al. Ventilatory responses to hypoxia and hypercapnia in stable methadone maintenance treatment patients. Chest. 2005;128:1339–47.PubMedCrossRef
94.
go back to reference Wang D, Teichtahl H, Drummer O, Goodman C, Cherry G, Cunnington D, et al. Central sleep apnea in stable methadone maintenance treatment patients. Chest. 2005;128:1348–56.PubMedCrossRef Wang D, Teichtahl H, Drummer O, Goodman C, Cherry G, Cunnington D, et al. Central sleep apnea in stable methadone maintenance treatment patients. Chest. 2005;128:1348–56.PubMedCrossRef
95.
go back to reference Sharkey KM, Kurth ME, Anderson BJ, Corso RP, Millman RP, Stein MD. Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints. Drug Alcohol Depend. 2010;108:77–83.PubMedCrossRef Sharkey KM, Kurth ME, Anderson BJ, Corso RP, Millman RP, Stein MD. Obstructive sleep apnea is more common than central sleep apnea in methadone maintenance patients with subjective sleep complaints. Drug Alcohol Depend. 2010;108:77–83.PubMedCrossRef
96.
go back to reference Wang D, Teichtahl H. Opioids, sleep architecture and sleep–disordered breathing. Sleep Med Rev. 2007;11:35–46.PubMedCrossRef Wang D, Teichtahl H. Opioids, sleep architecture and sleep–disordered breathing. Sleep Med Rev. 2007;11:35–46.PubMedCrossRef
97.
go back to reference Peles E, Schreiber S, Adelson M. Variables associated with perceived sleep disorders in methadone maintenance treatment (MMT) patients. Drug Alcohol Depend. 2006;82:103–10.PubMedCrossRef Peles E, Schreiber S, Adelson M. Variables associated with perceived sleep disorders in methadone maintenance treatment (MMT) patients. Drug Alcohol Depend. 2006;82:103–10.PubMedCrossRef
98.
go back to reference Wang D, Teichtahl H, Goodman C, Drummer O, Grunstein RR, Kronborg I. Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: possible mechanisms. J Clin Sleep Med. 2008;4:557–62.PubMed Wang D, Teichtahl H, Goodman C, Drummer O, Grunstein RR, Kronborg I. Subjective daytime sleepiness and daytime function in patients on stable methadone maintenance treatment: possible mechanisms. J Clin Sleep Med. 2008;4:557–62.PubMed
99.
go back to reference McCann UD, Sgambati FP, Schwartz AR, Ricaurte GA. Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumers. Neurology. 2009;73:2011–7.PubMedCrossRef McCann UD, Sgambati FP, Schwartz AR, Ricaurte GA. Sleep apnea in young abstinent recreational MDMA ("ecstasy") consumers. Neurology. 2009;73:2011–7.PubMedCrossRef
100.
go back to reference Chamberlin NL, Saper CB. The agony of the ecstasy: serotonin and obstructive sleep apnea. Neurology. 2009;73:1947–8.PubMedCrossRef Chamberlin NL, Saper CB. The agony of the ecstasy: serotonin and obstructive sleep apnea. Neurology. 2009;73:1947–8.PubMedCrossRef
Metadata
Title
Obstructive Sleep Apnea and Severe Mental Illness: Evolution and Consequences
Authors
Wei-Chen Lin
John W. Winkelman
Publication date
01-10-2012
Publisher
Current Science Inc.
Published in
Current Psychiatry Reports / Issue 5/2012
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-012-0307-6

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