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01-12-2020 | Obsessive-Compulsive Disorder | Study protocol

Metacognitive Training for Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial

Authors: Franziska Miegel, Cüneyt Demiralay, Steffen Moritz, Janina Wirtz, Birgit Hottenrott, Lena Jelinek

Published in: BMC Psychiatry | Issue 1/2020

Abstract

Background

A high number of patients with obsessive-compulsive disorder (OCD) do not receive cognitive-behavioral therapy with exposure and response prevention, which is the most effective treatment for OCD. Therefore, Metacognitive Training for OCD (MCT-OCD) was developed, which is a structured group therapy aiming at the modification of dysfunctional (meta-)cognitive biases, beliefs and coping styles. It can be administered by less trained personnel, thus may reach a higher number of patients.

An uncontrolled pilot study (MCT-OCD pilot version) provided first evidence that the training is highly accepted by patients; OC symptoms decreased with a high effect size (η²_partial = 0.50). The aim of the present study is to address the shortcomings of the pilot study (e.g., no control group) and to assess the efficacy of the revised version of the MCT-OCD in the framework of a randomized controlled trial.

Methods

Eighty patients with OCD will be recruited. After a blinded assessment at baseline (−t1), patients will be randomly assigned either to the intervention group (MCT-OCD; n = 40) or to a care as usual control group (n = 40). The MCT-OCD aims to enhance patients’ metacognitive competence in eight modules by addressing dysfunctional (meta-)cognitive biases and beliefs associated with OCD (e.g., intolerance of uncertainty). After 8 weeks, patients will be invited to a post assessment (t1), and then they will receive a follow-up online questionnaire 3 months following t1 (t2). The primary outcome is the Y-BOCS total score, and the secondary outcomes include the HDRS, OCI-R, OBQ-44, MCQ-30, WHOQOL-BREF, BDI-II, and subjective appraisal ratings of the MCT-OCD. We expect that OC symptoms will decrease more in the intervention group compared with the care as usual control group from –t1 to t1 and that treatment gains will be maintained until t2.

Discussion

The planned study is the first to investigate the MCT-OCD, a promising new treatment, in a randomized controlled trial. The MCT-OCD may help to overcome existing treatment barriers for patients with OCD.

Trial registration

German Registry for Clinical Studies (DRKS00013539), 22.02.2018.

Metacognition is defined as thinking about thinking or as cognition about cognitive processes [14].

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Title: Metacognitive Training for Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial
Authors: Franziska Miegel
Cüneyt Demiralay
Steffen Moritz
Janina Wirtz
Birgit Hottenrott
Lena Jelinek
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Obsessive-Compulsive Disorder
Anxiety
Published in: BMC Psychiatry / Issue 1/2020
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-020-02648-3

2024 ASCO Annual Meeting

Springer Medicine

Metacognitive Training for Obsessive-Compulsive Disorder: a study protocol for a randomized controlled trial

Abstract

Background

Methods

Discussion

Trial registration

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Discussion

Trial registration

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Borderline personality disorder and prior suicide attempts define a severity gradient among hospitalized adolescent suicide attempters

Violence rate dropped during a shift to individualized patient-oriented care in a high security forensic psychiatric ward

Prevalence of symptoms, ever having received a diagnosis and treatment of depression and anxiety, and associations with health service use amongst the general population in two Russian cities

Service user and family participation in mental health policy making in Timor-Leste: a qualitative study with multiple stakeholders