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31-01-2024 | Obesity | Original Article

The causal association between body fat distribution and risk of abdominal wall hernia: a two-sample Mendelian randomization study

Authors: Y. Xv, Q. Tao, N. Cao, R. Wu, Z. Ji

Published in: Hernia | Issue 2/2024

Abstract

Purpose

Obesity and a high body mass index (BMI) are considered as risk factors for abdominal wall hernia (AWH). However, anthropometric measures of body fat distribution (BFD) seem to be better indicators in the hernia field. This Mendelian randomization analysis aimed to generate more robust evidence for the impact of waist circumstance (WC), body, trunk, arm, and leg fat percentages (BFP, TFP, AFP, LFP) on AWH.

Methods

A univariable MR design was employed and the summary statistics allowing for assessment were obtained from the genome-wide association studies (GWASs). An inverse variance weighted (IVW) method was applied as the primary analysis, and the odds ratio value was used to evaluate the causal relationship between BFD and AWH.

Results

None of the MR-Egger regression intercepts deviated from null, indicating no evidence of horizontal pleiotropy (p > 0.05). The Cochran Q test showed heterogeneity between the genetic IVs for WC (p = 0.005; p = 0.005), TFP (p < 0.001; p < 0.001), AFP-L (p = 0.016; p = 0.015), LFP-R (p = 0.012; p = 0.009), and LFP-L (p < 0.001; p < 0.001). Taking the IVW random-effects model as gold standard, each standard deviation increment in genetically determined WC, BFP, TFP, AFP-R, AFP-L, LFP-R, and LFP-L raised the risk of AWH by 70.9%, 70.7%, 56.5%, 69.7%, 78.3%, 87.7%, and 72.5%, respectively.

Conclusions

This study proves the causal relationship between AWH and BFD, attracting more attention from BMI to BFD. It provides evidence-based medical evidence that healthy figure management can prevent AWH.

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Title: The causal association between body fat distribution and risk of abdominal wall hernia: a two-sample Mendelian randomization study
Authors: Y. Xv
Q. Tao
N. Cao
R. Wu
Z. Ji
Publication date: 31-01-2024
Publisher: Springer Paris
Keywords: Obesity
Obesity
Incisional Hernia
Published in: Hernia / Issue 2/2024
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI: https://doi.org/10.1007/s10029-023-02954-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The causal association between body fat distribution and risk of abdominal wall hernia: a two-sample Mendelian randomization study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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