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Indian Journal of Pediatrics

Open Access 04-04-2024 | Obesity | Original Article

Sleep Behaviors and the Shape of Subcortical Brain Structures in Children with Overweight/Obesity: A Cross-Sectional Study

Authors: Cristina Cadenas-Sanchez, Jairo H. Migueles, Lucia V. Torres-Lopez, Juan Verdejo-Román, David Jiménez-Pavón, Charles H. Hillman, Andrés Catena, Francisco B. Ortega

Published in: Indian Journal of Pediatrics

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Abstract

Objectives

To examine the relationship between sleep and subcortical brain structures using a shape analysis approach.

Methods

A total of 98 children with overweight/obesity (10.0 ± 1.1 y, 59 boys) were included in the cross-sectional analyses. Sleep behaviors (i.e., wake time, sleep onset time, total time in bed, total sleep time, sleep efficiency, and wakening after sleep onset) were estimated with wrist-worn accelerometers. The shape of the subcortical brain structures was acquired by magnetic resonance imaging. A partial correlation permutation approach was used to examine the relationship between sleep behaviors and brain shapes.

Results

Among all the sleep variables studied, only total time in bed was significantly related to pallidum and putamen structure, such that those children who spent more time in bed had greater expansions in the right and left pallidum (211–751 voxels, all p’s <0.04) and right putamen (1783 voxels, p = 0.03).

Conclusions

These findings suggest that more time in bed was related to expansions on two subcortical brain regions in children with overweight/obesity.
Appendix
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Metadata
Title
Sleep Behaviors and the Shape of Subcortical Brain Structures in Children with Overweight/Obesity: A Cross-Sectional Study
Authors
Cristina Cadenas-Sanchez
Jairo H. Migueles
Lucia V. Torres-Lopez
Juan Verdejo-Román
David Jiménez-Pavón
Charles H. Hillman
Andrés Catena
Francisco B. Ortega
Publication date
04-04-2024
Publisher
Springer India
Published in
Indian Journal of Pediatrics
Print ISSN: 0019-5456
Electronic ISSN: 0973-7693
DOI
https://doi.org/10.1007/s12098-024-05094-1